Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.1351 | 0.3838 | 0.3838 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.3324 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1351 | 0.3838 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.3324 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1351 | 0.3838 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0213 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0133 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.1351 | 0.3838 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0133 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.1351 | 0.3838 | 0.3838 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.1351 | 0.3838 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0417 | 0.0918 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0133 | 0.0031 | 0.0031 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1351 | 0.3838 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0133 | 0.0031 | 0.0031 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0133 | 0.0031 | 0.0031 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0417 | 0.0918 | 0.2392 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0133 | 0.0031 | 0.0031 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0133 | 0.0031 | 0.0031 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1351 | 0.3838 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0133 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.3324 | 1 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0133 | 0.0031 | 0.0031 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0417 | 0.0918 | 1 |
Onchocerca volvulus | 0.0213 | 0.0283 | 0.0738 | |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0417 | 0.0918 | 0.2392 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0133 | 0.0031 | 0.0031 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0417 | 0.0918 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0133 | 0.0031 | 0.0031 |
Onchocerca volvulus | 0.0165 | 0.0132 | 0.0344 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.3324 | 1 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0133 | 0.0031 | 0.0031 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0213 | 0.0283 | 0.0283 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0133 | 0.0031 | 0.0031 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0417 | 0.0918 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0133 | 0.0031 | 0.0031 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0935 | 0.2537 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0213 | 0.0283 | 0.0283 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.1351 | 0.3838 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0133 | 0.0031 | 0.0031 |
Onchocerca volvulus | 0.1351 | 0.3838 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.0484 | 0.0484 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1351 | 0.3838 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0133 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0101 | 0.0101 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0287 | 0.0515 | 0.0515 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1351 | 0.3838 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0133 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0101 | 0.0101 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.1351 | 0.3838 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.