Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1797 | 0.9064 | 0.9064 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0168 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.1797 | 0.9064 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0301 | 0.0741 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0168 | 0 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0168 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.1965 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1797 | 0.9064 | 1 |
Onchocerca volvulus | 0.1965 | 1 | 1 | |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0168 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1797 | 0.9064 | 0.5 |
Onchocerca volvulus | 0.1965 | 1 | 1 | |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0301 | 0.0741 | 1 |
Schistosoma mansoni | fatty acid desaturase | 0.0168 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1965 | 1 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1797 | 0.9064 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1965 | 1 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0168 | 0 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0168 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1797 | 0.9064 | 0.9064 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0261 | 0.0518 | 0.6984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.