Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acyl-CoA desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | stearic acid desaturase, putative | 0.0086 | 0.2323 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0084 | 0.2232 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0093 | 0.2549 | 0.2643 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0086 | 0.2323 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0957 | 0.0957 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0093 | 0.2549 | 0.5 |
Onchocerca volvulus | 0.0086 | 0.2323 | 1 | |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0093 | 0.2549 | 1 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0106 | 0.2992 | 0.2992 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0106 | 0.2992 | 0.2992 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0084 | 0.2232 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0093 | 0.2549 | 1 |
Loa Loa (eye worm) | CBP-B | 0.0076 | 0.1969 | 0.1969 |
Echinococcus multilocularis | CREB binding protein | 0.0075 | 0.194 | 0.194 |
Brugia malayi | acyl-CoA desaturase | 0.0068 | 0.1709 | 0.1709 |
Echinococcus granulosus | CREB binding protein | 0.0068 | 0.1709 | 0.1772 |
Echinococcus granulosus | CREB binding protein | 0.0106 | 0.2992 | 0.3102 |
Onchocerca volvulus | 0.0086 | 0.2323 | 1 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0301 | 0.9645 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0084 | 0.2232 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0068 | 0.1709 | 0.7358 |
Leishmania major | fatty-acid desaturase, putative | 0.0086 | 0.2323 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0068 | 0.1709 | 0.7358 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0093 | 0.2549 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0093 | 0.2549 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0068 | 0.1709 | 0.1709 |
Brugia malayi | TAZ zinc finger family protein | 0.0106 | 0.2992 | 0.2992 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0086 | 0.2323 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 63 nM | Inhibition of rat liver SCD1 using [3H]-stearoylCoA | ChEMBL. | 21324691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.