Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | core-binding factor, beta subunit | No references | |
Homo sapiens | runt-related transcription factor 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ezrin | 0.0146 | 0.1978 | 0.4464 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0058 | 0.0149 | 0.0335 |
Schistosoma mansoni | lozenge | 0.0067 | 0.0345 | 0.0557 |
Echinococcus granulosus | radixin | 0.0146 | 0.1978 | 0.4464 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0058 | 0.0149 | 0.0335 |
Echinococcus multilocularis | ezrin | 0.0146 | 0.1978 | 0.4464 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0058 | 0.0149 | 0.0149 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0149 | 0.0149 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.01 | 0.01 |
Echinococcus multilocularis | radixin | 0.0146 | 0.1978 | 0.4464 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.01 | 0.0225 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3183 | 0.5145 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0149 | 0.024 |
Echinococcus multilocularis | Protein lozenge | 0.0067 | 0.0345 | 0.0778 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0202 | 0.0202 |
Echinococcus multilocularis | H17g protein, tegumental antigen | 0.0265 | 0.4431 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.01 | 0.0161 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0066 | 0.0313 | 0.0506 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0149 | 0.0149 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.01 | 0.0225 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0058 | 0.0149 | 0.0149 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0066 | 0.0313 | 0.0313 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0227 | 0.3645 | 0.8226 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0313 | 0.0313 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.01 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0202 | 0.0202 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0202 | 0.0202 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0066 | 0.0313 | 0.0707 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0163 | 0.233 | 0.3766 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.01 | 0.0225 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0235 | 0.3817 | 0.617 |
Loa Loa (eye worm) | runx1 | 0.0067 | 0.0345 | 0.0345 |
Brugia malayi | hypothetical protein | 0.0102 | 0.106 | 0.106 |
Loa Loa (eye worm) | moesin | 0.0265 | 0.4431 | 0.4431 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0066 | 0.0313 | 0.0707 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.01 | 0.01 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.6187 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3183 | 0.5145 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.106 | 0.106 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0202 | 0.0202 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0066 | 0.0313 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0149 | 0.0149 |
Brugia malayi | neurofibromatosis homolog protein 1 | 0.0152 | 0.2101 | 0.2101 |
Loa Loa (eye worm) | MBCTL1 | 0.0066 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.106 | 0.106 |
Echinococcus multilocularis | geminin | 0.0205 | 0.3183 | 0.7184 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0058 | 0.0149 | 0.024 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0058 | 0.0149 | 0.0335 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0066 | 0.0313 | 0.0707 |
Onchocerca volvulus | 0.0058 | 0.0149 | 0.0149 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.01 | 0.0225 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.01 | 0.0161 |
Echinococcus granulosus | geminin | 0.0205 | 0.3183 | 0.7184 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0058 | 0.0149 | 0.0335 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0265 | 0.4431 | 0.7161 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0149 | 0.024 |
Echinococcus granulosus | H17g protein tegumental antigen | 0.0265 | 0.4431 | 1 |
Brugia malayi | Moesin/ezrin/radixin homolog 1 | 0.0265 | 0.4431 | 0.4431 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0227 | 0.3645 | 0.8226 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7943 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 2.5929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.