Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | endonuclease G, putative | 0.0063 | 0 | 0.5 |
Leishmania major | endonuclease G, putative | 0.0063 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0104 | 0.2329 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2329 | 0.1068 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0225 | 0.9088 | 0.9088 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0104 | 0.2329 | 0.2563 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0088 | 0.1412 | 0.1412 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Echinococcus granulosus | ectonucleotide | 0.0088 | 0.1412 | 0.1412 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Trypanosoma brucei | endonuclease G, putative | 0.0063 | 0 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0104 | 0.2329 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0063 | 0 | 0.5 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0104 | 0.2329 | 0.2329 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0088 | 0.1412 | 0.1412 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0104 | 0.2329 | 0.2563 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 1 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0063 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0063 | 0 | 0.5 |
Onchocerca volvulus | 0.0225 | 0.9088 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Echinococcus multilocularis | ectonucleotide | 0.0088 | 0.1412 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2329 | 0.1068 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2329 | 0.1068 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0104 | 0.2329 | 0.2329 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0225 | 0.9088 | 0.8938 |
Schistosoma mansoni | hypothetical protein | 0.0225 | 0.9088 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 32 ug ml-1 | Cytotoxic concentration reducing HEL cell growth by 50%. | ChEMBL. | 12217359 |
CC50 (functional) | = 32 ug ml-1 | Cytotoxic concentration reducing HEL cell growth by 50%. | ChEMBL. | 12217359 |
IC50 (functional) | = 2.1 ug ml-1 | Antiproliferative activity was tested against murine leukemia cells-L1210/0 | ChEMBL. | 12217359 |
IC50 (functional) | = 2.1 ug ml-1 | Antiproliferative activity was tested against murine leukemia cells-L1210/0 | ChEMBL. | 12217359 |
IC50 (functional) | = 2.6 ug ml-1 | Antiproliferative activity was tested against human T-lymphocyte cells-Molt 4/C8 | ChEMBL. | 12217359 |
IC50 (functional) | = 3.4 ug ml-1 | Antiproliferative activity was tested against human T-lymphocyte cells-CEM/0 | ChEMBL. | 12217359 |
IC50 (functional) | > 20 ug ml-1 | Antiviral activity was tested against TK+ varicella-zoster virus YS which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 20 ug ml-1 | Antiviral activity was tested against TK+ varicella-zoster virus OKA which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 20 ug ml-1 | Antiviral activity was tested against TK- varicella-zoster virus 07/1 which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | > 20 ug ml-1 | Antiviral activity was tested against TK- varicella-zoster virus YS/R which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | = 30 ug ml-1 | Antiviral activity was tested against human cytomegalovirus AD-169 which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
IC50 (functional) | = 32 ug ml-1 | Antiviral activity was tested against human cytomegalovirus Davis which reduces virus plaque formation by 50% | ChEMBL. | 12217359 |
MCC (functional) | > 50 ug ml-1 | Minimum cytotoxic concentration against HEL cell morphology. | ChEMBL. | 12217359 |
MCC (functional) | > 50 ug ml-1 | Minimum cytotoxic concentration against HEL cell morphology. | ChEMBL. | 12217359 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 12217359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.