Detailed information for compound 150665

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 611.81 | Formula: C39H49NO5
  • H donors: 0 H acceptors: 4 LogP: 7.28 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cccc2c1CCC(C2=O)Cc1ccncc1.CCC(=O)OC1CCC2C1(C)CCC1C2CCC2=CC(=O)CCC12C
  • InChi: 1S/C22H32O3.C17H17NO2/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3;1-20-16-4-2-3-15-14(16)6-5-13(17(15)19)11-12-7-9-18-10-8-12/h13,16-19H,4-12H2,1-3H3;2-4,7-10,13H,5-6,11H2,1H3
  • InChiKey: IGOBFPGMKSCLRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Schistosoma mansoni nAChR subunit 0.0117 0.0177 0.041
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0254 0.0497 0.0497
Onchocerca volvulus 0.0989 0.2213 0.814
Echinococcus granulosus rhodopsin orphan GPCR 0.024 0.0466 0.0466
Schistosoma mansoni hypothetical protein 0.024 0.0466 0.1085
Schistosoma mansoni adenoreceptor 0.024 0.0466 0.1085
Loa Loa (eye worm) integrin alpha pat-2 0.009 0.0114 0.0407
Loa Loa (eye worm) SRC-1 0.0185 0.0336 0.1239
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0199 0.037 0.037
Schistosoma mansoni nAChR subunit 0.0254 0.0497 0.116
Echinococcus multilocularis neuropeptide Y receptor 0.024 0.0466 0.0466
Echinococcus granulosus neuropeptide FF receptor 2 0.024 0.0466 0.0466
Onchocerca volvulus 0.0189 0.0345 0.0669
Loa Loa (eye worm) PAN domain-containing protein 0.0189 0.0345 0.1271
Echinococcus multilocularis g-protein coupled receptor 0.024 0.0466 0.0466
Echinococcus multilocularis c src tyrosine kinase 0.0042 0.0002 0.0002
Loa Loa (eye worm) DOMON domain-containing protein 0.0176 0.0317 0.1166
Onchocerca volvulus 0.0199 0.037 0.0771
Onchocerca volvulus 0.0189 0.0345 0.0669
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1188 0.2678 0.6266
Schistosoma mansoni hypothetical protein 0.024 0.0466 0.1085
Echinococcus granulosus rhodopsin orphan GPCR 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0119 0.0183 0.0667
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Echinococcus multilocularis somatostatin receptor 0.024 0.0466 0.0466
Onchocerca volvulus 0.024 0.0466 0.1153
Schistosoma mansoni opsin-like receptor 0.024 0.0466 0.1085
Echinococcus multilocularis enteropeptidase 0.0199 0.037 0.037
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Echinococcus multilocularis shaker cognate 0.0045 0.001 0.001
Brugia malayi G-protein coupled receptor 0.024 0.0466 0.1732
Echinococcus multilocularis potassium voltage gated channel protein 0.0045 0.001 0.001
Echinococcus multilocularis fmrfamide receptor 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus neuropeptide receptor 0.024 0.0466 0.0466
Schistosoma mansoni tyrosine kinase 0.0185 0.0336 0.0782
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0045 0.001 0.001
Onchocerca volvulus 0.0189 0.0345 0.0669
Brugia malayi hypothetical protein 0.0117 0.0177 0.0655
Echinococcus multilocularis tyrosine protein kinase HCK 0.0148 0.0251 0.0251
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0503 0.1079 0.1079
Echinococcus multilocularis integrin alpha 3 0.0043 0.0005 0.0005
Brugia malayi Trypsin family protein 0.0199 0.037 0.1375
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0045 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0177 0.0655
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.024 0.0466 0.0466
Brugia malayi G protein-coupled receptor 0.024 0.0466 0.1732
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.024 0.0466 0.0466
Echinococcus multilocularis rhodopsin orphan GPCR 0.024 0.0466 0.0466
Loa Loa (eye worm) melatonin receptor type 1A 0.024 0.0466 0.1723
Schistosoma mansoni hypothetical protein 0.024 0.0466 0.1085
Onchocerca volvulus 0.0189 0.0345 0.0669
Echinococcus granulosus tyrosine protein kinase Src42A 0.0162 0.0282 0.0282
Echinococcus multilocularis neuropeptide receptor 0.024 0.0466 0.0466
Brugia malayi Dopamine receptor protein 1 0.024 0.0466 0.1732
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Onchocerca volvulus 0.0189 0.0345 0.0669
Loa Loa (eye worm) hypothetical protein 0.0189 0.0345 0.1271
Onchocerca volvulus 0.0176 0.0317 0.0557
Loa Loa (eye worm) hypothetical protein 0.0575 0.1247 0.4646
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0254 0.0497 0.0497
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.024 0.0466 0.0466
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0254 0.0497 0.1842
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0045 0.001 0.001
Echinococcus multilocularis nAChR subunit 0.0137 0.0225 0.0225
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.0336 0.0336
Brugia malayi AKH receptor 0.024 0.0466 0.1732
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.024 0.0466 0.1723
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0185 0.0336 0.0336
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0119 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0295 0.0593 0.1383
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0254 0.0497 0.0497
Schistosoma mansoni histamine h1 receptor 0.024 0.0466 0.1085
Brugia malayi hypothetical protein 0.0117 0.0177 0.0655
Loa Loa (eye worm) hypothetical protein 0.0189 0.0345 0.1271
Brugia malayi G protein-coupled receptor F59B2.13 0.024 0.0466 0.1732
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0254 0.0497 0.116
Echinococcus multilocularis rhodopsin orphan GPCR 0.024 0.0466 0.0466
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0117 0.0177 0.0655
Schistosoma mansoni serine-type protease inhibitor 0.1871 0.4273 1
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0254 0.0497 0.0497
Loa Loa (eye worm) ACC-1 protein 0.0254 0.0497 0.1842
Echinococcus multilocularis rhodopsin orphan GPCR 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis dro:myosuppressin receptor 0.024 0.0466 0.0466
Brugia malayi Melatonin receptor type 1A 0.024 0.0466 0.1732
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis neuropeptide s receptor 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0254 0.0497 0.1851
Echinococcus granulosus fmrfamide receptor 0.024 0.0466 0.0466
Onchocerca volvulus 0.0137 0.0225 0.019
Schistosoma mansoni biogenic amine (5HT) receptor 0.024 0.0466 0.1085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Echinococcus granulosus integrin alpha 3 0.0043 0.0005 0.0005
Brugia malayi Muscle positioning protein 4 0.0181 0.0326 0.1212
Echinococcus granulosus alpha 1A adrenergic receptor 0.024 0.0466 0.0466
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0254 0.0497 0.116
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0119 0.0183 0.0677
Brugia malayi follicle stimulating hormone receptor 0.024 0.0466 0.1732
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0823
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0119 0.0183 0.0424
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0119 0.0183 0.0183
Brugia malayi putative neuropeptide receptor 0.024 0.0466 0.1732
Echinococcus granulosus tissue type plasminogen activator 0.0295 0.0593 0.0593
Echinococcus granulosus biogenic amine 5HT receptor 0.024 0.0466 0.0466
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0254 0.0497 0.1851
Echinococcus granulosus G protein coupled receptor 139 0.024 0.0466 0.0466
Echinococcus multilocularis tissue type plasminogen activator 0.0295 0.0593 0.0593
Brugia malayi Dopamine receptor protein 2 0.024 0.0466 0.1732
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Echinococcus granulosus 7TM GPCR rhodopsin 0.024 0.0466 0.0466
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.024 0.0466 0.1085
Echinococcus granulosus peptide allatostatin:somatostatin 0.024 0.0466 0.0466
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Brugia malayi Trypsin-like protease protein 5 0.0199 0.037 0.1375
Echinococcus granulosus rhodopsin orphan GPCR 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.0497 0.1851
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Schistosoma mansoni neuropeptide f receptor 76f 0.024 0.0466 0.1085
Onchocerca volvulus 0.024 0.0466 0.1153
Onchocerca volvulus 0.024 0.0466 0.1153
Onchocerca volvulus 0.0575 0.1247 0.4277
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Echinococcus granulosus glycine receptor subunit beta 0.0254 0.0497 0.0497
Toxoplasma gondii kringle domain-containing protein 0.0295 0.0593 0.0625
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0526 0.1133 0.4224
Echinococcus multilocularis neuropeptides capa receptor 0.024 0.0466 0.0466
Echinococcus multilocularis potassium voltage gated channel protein 0.0526 0.1133 0.1133
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0185 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0199 0.037 0.1366
Echinococcus granulosus somatostatin receptor 0.024 0.0466 0.0466
Onchocerca volvulus 0.0137 0.0225 0.019
Echinococcus granulosus tyrosine kinase 0.0167 0.0294 0.0294
Onchocerca volvulus 0.0575 0.1247 0.4277
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus rhodopsin orphan GPCR 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0051 0.0023 0.0067
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0162 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi Cation transporter family protein 0.0254 0.0497 0.1851
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.024 0.0466 0.1723
Brugia malayi Dopamine receptor 0.024 0.0466 0.1732
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.024 0.0466 0.0466
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0227 0.0435 0.1015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.024 0.0466 0.1085
Loa Loa (eye worm) ACC-1 protein 0.0254 0.0497 0.1842
Echinococcus multilocularis rhodopsin orphan GPCR 0.024 0.0466 0.0466
Echinococcus multilocularis g protein coupled receptor 0.024 0.0466 0.0466
Schistosoma mansoni amine GPCR 0.024 0.0466 0.1085
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Loa Loa (eye worm) PAN domain-containing protein 0.0189 0.0345 0.1271
Schistosoma mansoni neuropeptide receptor 0.024 0.0466 0.1085
Echinococcus granulosus tyrosine protein kinase Blk 0.0167 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0254 0.0497 0.1842
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0254 0.0497 0.1842
Schistosoma mansoni integrin alpha-ps 0.009 0.0114 0.0262
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0254 0.0497 0.1851
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.0336 0.0336
Schistosoma mansoni biogenic amine receptor 0.024 0.0466 0.1085
Schistosoma mansoni neuropeptide F-like receptor 0.024 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0129 0.0129
Schistosoma mansoni opsin-like receptor 0.024 0.0466 0.1085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0023 0.0078
Onchocerca volvulus 0.0189 0.0345 0.0669
Schistosoma mansoni hypothetical protein 0.024 0.0466 0.1085
Loa Loa (eye worm) TYRA-2 protein 0.024 0.0466 0.1723
Echinococcus granulosus potassium voltage gated channel protein 0.0045 0.001 0.001
Loa Loa (eye worm) LGC-31 protein 0.0254 0.0497 0.1842
Echinococcus granulosus enteropeptidase 0.0199 0.037 0.037
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.024 0.0466 0.0466
Echinococcus multilocularis sodium channel protein 0.0062 0.0049 0.0049
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0185 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0117 0.0177 0.0177
Schistosoma mansoni biogenic amine (dopamine) receptor 0.024 0.0466 0.1085
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0254 0.0497 0.1842
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0254 0.0497 0.0497
Schistosoma mansoni nAChR subunit 0.0254 0.0497 0.116
Loa Loa (eye worm) neuropeptide F receptor 0.024 0.0466 0.1723
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis rhodopsin orphan GPCR 0.024 0.0466 0.0466
Brugia malayi Kringle domain containing protein 0.0295 0.0593 0.2207
Brugia malayi hypothetical protein 0.0199 0.037 0.1375
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.024 0.0466 0.1085
Schistosoma mansoni integrin alpha-4 0.0383 0.0799 0.1865
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0254 0.0497 0.1842
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0117 0.0177 0.0645
Schistosoma mansoni amine GPCR 0.024 0.0466 0.1085
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0119 0.0183 0.0183
Echinococcus granulosus neuropeptide receptor 0.024 0.0466 0.0466
Onchocerca volvulus 0.0189 0.0345 0.0669
Echinococcus granulosus tyrosine protein kinase Src64B 0.0185 0.0336 0.0336
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0167 0.0294 0.0294
Schistosoma mansoni integrin alpha-ps 0.0047 0.0014 0.0027
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0254 0.0497 0.0497
Echinococcus multilocularis glycoprotein Antigen 5 0.0199 0.037 0.037
Brugia malayi Tachykinin-like peptides receptor 99D 0.024 0.0466 0.1732
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0043 0.0005 0.0011
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus neuropeptide s receptor 0.024 0.0466 0.0466
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0137 0.0225 0.0522
Schistosoma mansoni nAChR subunit 0.0117 0.0177 0.041
Onchocerca volvulus 0.024 0.0466 0.1153
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus g protein coupled receptor 0.024 0.0466 0.0466
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0254 0.0497 0.1851
Loa Loa (eye worm) hypothetical protein 0.0189 0.0345 0.1271
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0019
Brugia malayi Cation transporter family protein 0.0254 0.0497 0.1851
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi Trypsin family protein 0.1188 0.2678 1
Echinococcus multilocularis neuropeptide receptor 0.024 0.0466 0.0466
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0137 0.0225 0.0833
Loa Loa (eye worm) TK/ROR protein kinase 0.03 0.0605 0.2244
Echinococcus multilocularis rhodopsin orphan GPCR 0.024 0.0466 0.0466
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0137 0.0225 0.0833
Echinococcus multilocularis tachykinin peptides receptor 99D 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0185 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Loa Loa (eye worm) neuropeptide F receptor 0.024 0.0466 0.1723
Echinococcus multilocularis integrin alpha ps 0.0043 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Schistosoma mansoni biogenic amine (5HT) receptor 0.024 0.0466 0.1085
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0137 0.0225 0.0833
Echinococcus multilocularis potassium voltage gated channel protein 0.0045 0.001 0.001
Onchocerca volvulus Putative nachr subunit 0.0254 0.0497 0.128
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.024 0.0466 0.0466
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0042 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0823
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi Serotonin receptor 0.024 0.0466 0.1732
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4325 1 1
Echinococcus granulosus c src tyrosine kinase 0.0042 0.0002 0.0002
Plasmodium falciparum cysteine repeat modular protein 1 0.0295 0.0593 0.5
Brugia malayi jmjC domain containing protein 0.0096 0.0129 0.0474
Loa Loa (eye worm) hypothetical protein 0.0181 0.0326 0.1203
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0199 0.037 0.0862
Echinococcus multilocularis biogenic amine (5HT) receptor 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0823
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0575 0.1247 0.2915
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi Trypsin family protein 0.0199 0.037 0.1375
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0137 0.0225 0.0522
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085
Echinococcus multilocularis g protein coupled receptor 0.024 0.0466 0.0466
Schistosoma mansoni amine GPCR 0.024 0.0466 0.1085
Echinococcus granulosus tm gpcr rhodopsin 0.024 0.0466 0.0466
Schistosoma mansoni voltage-gated potassium channel 0.0526 0.1133 0.2647
Brugia malayi Serotonin/octopamine receptor family protein 7 0.024 0.0466 0.1732
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Brugia malayi hypothetical protein 0.0117 0.0177 0.0655
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0254 0.0497 0.1851
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0119 0.0183 0.0183
Schistosoma mansoni voltage-gated cation channel 0.0119 0.0183 0.0424
Echinococcus granulosus dro:myosuppressin receptor 0.024 0.0466 0.0466
Schistosoma mansoni hypothetical protein 0.0199 0.037 0.0862
Schistosoma mansoni serine-type protease inhibitor 0.1871 0.4273 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0254 0.0497 0.0497
Schistosoma mansoni neurotransmitter gated ion channel 0.0137 0.0225 0.0522
Brugia malayi GnHR receptor homolog 0.024 0.0466 0.1732
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.0497 0.1851
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0019
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0185 0.0336 0.0336
Loa Loa (eye worm) PAN domain-containing protein 0.0189 0.0345 0.1271
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.024 0.0466 0.0466
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0023 0.0067
Echinococcus granulosus thyrotropin releasing hormone receptor 0.024 0.0466 0.0466
Echinococcus granulosus potassium voltage gated channel protein 0.0526 0.1133 0.1133
Brugia malayi protein-tyrosine kinase 0.0167 0.0294 0.1091
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.024 0.0466 0.1085
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0254 0.0497 0.1851
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.0497 0.1851
Onchocerca volvulus 0.0189 0.0345 0.0669
Loa Loa (eye worm) hypothetical protein 0.1188 0.2678 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.008 0.0092 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Echinococcus multilocularis rhodopsin orphan GPCR 0.024 0.0466 0.0466
Echinococcus granulosus glycoprotein Antigen 5 0.0199 0.037 0.037
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0185 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0199 0.037 0.1366
Brugia malayi RE15519p 0.024 0.0466 0.1732
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0045 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0119 0.0183 0.0424
Echinococcus granulosus neuropeptide Y receptor 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi putative neuropeptide receptor NPR1 0.024 0.0466 0.1732
Echinococcus multilocularis integrin alpha ps 0.009 0.0114 0.0114
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0151
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0185 0.0336 0.0336
Echinococcus multilocularis alpha 1A adrenergic receptor 0.024 0.0466 0.0466
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0199 0.037 0.037
Onchocerca volvulus 0.024 0.0466 0.1153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi Serotonin receptor 0.024 0.0466 0.1732
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Loa Loa (eye worm) hypothetical protein 0.0189 0.0345 0.1271
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus serotonin receptor 0.024 0.0466 0.0466
Schistosoma mansoni biogenic amine (dopamine) receptor 0.024 0.0466 0.1085
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0023 0.0078
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0466 0.1723
Echinococcus multilocularis tyrosine protein kinase Srms 0.0167 0.0294 0.0294
Schistosoma mansoni nAChR subunit 0.0254 0.0497 0.116
Echinococcus granulosus g protein coupled receptor 0.024 0.0466 0.0466
Loa Loa (eye worm) trypsin family protein 0.0199 0.037 0.1366
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus multilocularis neuropeptide FF receptor 2 0.024 0.0466 0.0466
Toxoplasma gondii PAN domain-containing protein 0.1887 0.431 1
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis rhodopsin orphan GPCR 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0047 0.0014 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.024 0.0466 0.0466
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0254 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0189 0.0345 0.1271
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Brugia malayi ORL1-like opioid receptor 0.024 0.0466 0.1732
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0117 0.0177 0.0655
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0117 0.0177 0.0645
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0254 0.0497 0.0497
Schistosoma mansoni neuropeptide receptor 0.024 0.0466 0.1085
Onchocerca volvulus 0.0199 0.037 0.0771
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Loa Loa (eye worm) PAN domain-containing protein 0.0189 0.0345 0.1271
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.0497 0.1851
Loa Loa (eye worm) G-protein coupled receptor 0.024 0.0466 0.1723
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis neuropeptide receptor A26 0.024 0.0466 0.0466
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0189 0.0345 0.1271
Brugia malayi larval opioid receptor 0.024 0.0466 0.1732
Echinococcus granulosus integrin alpha ps 0.009 0.0114 0.0114
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0119 0.0183 0.0183
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0199 0.037 0.037
Onchocerca volvulus Neuropeptide F receptor homolog 0.024 0.0466 0.1153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085
Onchocerca volvulus 0.024 0.0466 0.1153
Brugia malayi Cation transporter family protein 0.0575 0.1247 0.4652
Loa Loa (eye worm) hypothetical protein 0.0045 0.001 0.0019
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0117 0.0177 0.0177
Echinococcus granulosus neuropeptides capa receptor 0.024 0.0466 0.0466
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0199 0.037 0.1375
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Brugia malayi CUB domain containing protein 0.006 0.0045 0.0161
Loa Loa (eye worm) hypothetical protein 0.1188 0.2678 1
Brugia malayi hypothetical protein 0.0117 0.0177 0.0655
Schistosoma mansoni neuropeptide receptor 0.024 0.0466 0.1085
Onchocerca volvulus 0.0176 0.0317 0.0557
Onchocerca volvulus 0.024 0.0466 0.1153
Echinococcus granulosus tm gpcr rhodopsin 0.024 0.0466 0.0466
Schistosoma mansoni nAChR subunit 0.0254 0.0497 0.116
Onchocerca volvulus 0.024 0.0466 0.1153
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0254 0.0497 0.0497
Echinococcus multilocularis neuropeptides capa receptor 0.024 0.0466 0.0466
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.024 0.0466 0.0466
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0199 0.037 0.0862
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0117 0.0177 0.0177
Echinococcus granulosus rhodopsin orphan GPCR 0.024 0.0466 0.0466
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0575 0.1247 0.2915
Echinococcus granulosus g protein coupled receptor 0.024 0.0466 0.0466
Onchocerca volvulus 0.0176 0.0317 0.0557
Echinococcus multilocularis g protein coupled receptor 0.024 0.0466 0.0466
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.024 0.0466 0.1085
Echinococcus granulosus rhodopsin orphan GPCR 0.024 0.0466 0.0466
Entamoeba histolytica protein kinase, putative 0.0148 0.0251 1
Echinococcus granulosus allatostatin A receptor 0.024 0.0466 0.0466
Onchocerca volvulus 0.0575 0.1247 0.4277
Schistosoma mansoni amine GPCR 0.024 0.0466 0.1085
Echinococcus granulosus glycine receptor subunit alpha 1 0.0254 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0185 0.0336 0.0336
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.024 0.0466 0.1723
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0176 0.0317 0.1166
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.024 0.0466 0.1723
Onchocerca volvulus 0.024 0.0466 0.1153
Schistosoma mansoni acetylcholine receptor-related 0.0117 0.0177 0.041
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0823
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0045 0.001 0.001
Echinococcus granulosus glycine receptor subunit alpha 1 0.0254 0.0497 0.0497
Mycobacterium ulcerans hypothetical protein 0.0199 0.037 0.5
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0045 0.001 0.001
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0117 0.0177 0.0655
Schistosoma mansoni myosin xvIII 0.024 0.0466 0.1085
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0046 0.0154
Schistosoma mansoni opsin-like receptor 0.024 0.0466 0.1085
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0254 0.0497 0.116
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus multilocularis fmrfamide receptor 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Echinococcus granulosus tyrosine protein kinase HCK 0.0148 0.0251 0.0251
Schistosoma mansoni nAChR subunit 0.0254 0.0497 0.116
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0254 0.0497 0.0497
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0254 0.0497 0.0497
Brugia malayi sulfakinin receptor protein 0.024 0.0466 0.1732
Onchocerca volvulus 0.0199 0.037 0.0771
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0042 0.0002 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.0497 0.1851
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.0336 0.0336
Onchocerca volvulus 0.0254 0.0497 0.128
Onchocerca volvulus 0.0254 0.0497 0.128
Loa Loa (eye worm) PAN domain-containing protein 0.0189 0.0345 0.1271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Onchocerca volvulus 0.024 0.0466 0.1153
Leishmania major hypothetical protein, conserved 0.0295 0.0593 0.5
Loa Loa (eye worm) hypothetical protein 0.0458 0.0974 0.3626
Loa Loa (eye worm) hypothetical protein 0.006 0.0045 0.0151
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0199 0.037 0.0862
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0083 0.0189
Echinococcus multilocularis transfer RNA-Gly 0.0045 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0823
Onchocerca volvulus 0.024 0.0466 0.1153
Echinococcus granulosus 7tm_1 domain containing protein 0.024 0.0466 0.0466
Echinococcus granulosus glycine receptor subunit alpha 1 0.0254 0.0497 0.0497
Echinococcus granulosus integrin alpha ps 0.0043 0.0005 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1248 0.2819 0.6595
Echinococcus multilocularis nAChR subunit 0.0254 0.0497 0.0497
Echinococcus granulosus biogenic amine 5HT receptor 0.024 0.0466 0.0466
Echinococcus granulosus voltage gated potassium channel 0.0045 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0199 0.037 0.1366
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0045 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus neuropeptide Y receptor 0.024 0.0466 0.0466
Echinococcus granulosus Mastin 0.0199 0.037 0.037
Echinococcus multilocularis voltage dependent calcium channel 0.0119 0.0183 0.0183
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0199 0.037 0.0862
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0045 0.001 0.003
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Onchocerca volvulus 0.0176 0.0317 0.0557
Schistosoma mansoni neuropeptide receptor 0.024 0.0466 0.1085
Schistosoma mansoni cercarial elastase (S01 family) 0.0199 0.037 0.0862
Loa Loa (eye worm) hypothetical protein 0.005 0.0022 0.0064
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis Mastin 0.0199 0.037 0.037
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0254 0.0497 0.0497
Echinococcus multilocularis sex peptide receptor 0.024 0.0466 0.0466
Schistosoma mansoni biogenic amine (dopamine) receptor 0.024 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0823
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0117 0.0177 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0295 0.0593 1
Echinococcus granulosus transmembrane protease serine 3 0.0199 0.037 0.037
Brugia malayi neuropeptide F receptor 0.024 0.0466 0.1732
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Loa Loa (eye worm) hypothetical protein 0.0047 0.0014 0.0032
Onchocerca volvulus 0.024 0.0466 0.1153
Schistosoma mansoni growth hormone secretagogue receptor 0.024 0.0466 0.1085
Echinococcus granulosus nAChR subunit 0.0137 0.0225 0.0225
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.024 0.0466 0.1153
Echinococcus multilocularis tyrosine protein kinase Abl 0.0042 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0119 0.0183 0.0183
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Echinococcus granulosus tyrosine protein kinase Lyn 0.0185 0.0336 0.0336
Onchocerca volvulus 0.0199 0.037 0.0771
Loa Loa (eye worm) hypothetical protein 0.0189 0.0345 0.1271
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0254 0.0497 0.1851
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0199 0.037 0.037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085
Echinococcus granulosus nAChR subunit 0.0254 0.0497 0.0497
Brugia malayi Integrin alpha pat-2 precursor 0.009 0.0114 0.0417
Onchocerca volvulus 0.024 0.0466 0.1153
Schistosoma mansoni neurotransmitter gated ion channel 0.0117 0.0177 0.041
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0177 0.0655
Echinococcus multilocularis voltage gated potassium channel 0.0045 0.001 0.001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.024 0.0466 0.0466
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0119 0.0183 0.0183
Schistosoma mansoni neuropeptide F-like receptor 0.024 0.0466 0.1085
Echinococcus granulosus potassium voltage gated channel protein 0.0045 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.024 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.0199 0.037 0.1366
Schistosoma mansoni alpha-1 adrenergic receptor 0.024 0.0466 0.1085
Echinococcus granulosus orexin receptor type 2 0.024 0.0466 0.0466
Brugia malayi SRC-1 0.0185 0.0336 0.1249
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Schistosoma mansoni voltage-gated potassium channel 0.0526 0.1133 0.2647
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Brugia malayi excitatory GABA receptor EXP-1A 0.0254 0.0497 0.1851
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.024 0.0466 0.1732
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0254 0.0497 0.1851
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.024 0.0466 0.1732
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0117 0.0177 0.0655
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0254 0.0497 0.0497
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0045 0.001 0.001
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Echinococcus granulosus g-protein coupled receptor 0.024 0.0466 0.0466
Loa Loa (eye worm) G-protein coupled receptor 0.024 0.0466 0.1723
Onchocerca volvulus 0.0189 0.0345 0.0669
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0295 0.0593 0.5
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Onchocerca volvulus 0.0295 0.0593 0.1661
Brugia malayi G-protein coupled receptor 0.024 0.0466 0.1732
Echinococcus multilocularis orexin receptor type 2 0.024 0.0466 0.0466
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.024 0.0466 0.1085
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0254 0.0497 0.0497
Loa Loa (eye worm) calcium channel 0.0119 0.0183 0.0667
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0137 0.0225 0.0833
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Loa Loa (eye worm) TK protein kinase 0.0148 0.0251 0.092
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0254 0.0497 0.1851
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0254 0.0497 0.1842
Brugia malayi hypothetical protein 0.0117 0.0177 0.0655
Brugia malayi PAN domain containing protein 0.0189 0.0345 0.128
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.001 0.0019
Onchocerca volvulus 0.1188 0.2678 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.024 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Schistosoma mansoni tyrosine kinase 0.0185 0.0336 0.0782
Echinococcus multilocularis G-protein coupled receptor, putative 0.024 0.0466 0.0466
Echinococcus multilocularis G protein coupled receptor 139 0.024 0.0466 0.0466
Onchocerca volvulus 0.024 0.0466 0.1153
Echinococcus multilocularis transmembrane protease serine 3 0.0199 0.037 0.037
Brugia malayi Trypsin family protein 0.0199 0.037 0.1375
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Schistosoma mansoni acetylcholine receptor subunit beta 0.0117 0.0177 0.041
Echinococcus multilocularis tyrosine protein kinase Blk 0.0167 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Brugia malayi Protein kinase domain containing protein 0.03 0.0605 0.2252
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.024 0.0466 0.1732
Schistosoma mansoni biogenic amine receptor 0.024 0.0466 0.1085
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.024 0.0466 0.0466
Echinococcus multilocularis voltage dependent calcium channel 0.0119 0.0183 0.0183
Echinococcus granulosus neuropeptides capa receptor 0.024 0.0466 0.0466
Schistosoma mansoni hypothetical protein 0.0176 0.0317 0.0737
Echinococcus granulosus hypothetical protein 0.024 0.0466 0.0466
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0185 0.0336 0.0336
Echinococcus multilocularis neuropeptide Y receptor 0.024 0.0466 0.0466
Echinococcus multilocularis integrin alpha ps 0.009 0.0114 0.0114
Onchocerca volvulus 0.0189 0.0345 0.0669
Onchocerca volvulus 0.024 0.0466 0.1153
Loa Loa (eye worm) hypothetical protein 0.0526 0.1133 0.4218
Onchocerca volvulus 0.0181 0.0326 0.0597
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0254 0.0497 0.0497
Brugia malayi SEA domain containing protein 0.0176 0.0317 0.1176
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0526 0.1133 0.1133
Echinococcus granulosus shaker cognate 0.0045 0.001 0.001
Loa Loa (eye worm) GABA receptor subunit 0.0137 0.0225 0.0823
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Echinococcus multilocularis glycine receptor subunit beta 0.0254 0.0497 0.0497
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0062 0.0049 0.0049
Schistosoma mansoni nAChR subunit 0.0254 0.0497 0.116
Echinococcus multilocularis serotonin receptor 0.024 0.0466 0.0466
Onchocerca volvulus 0.0199 0.037 0.0771
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0823
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Echinococcus granulosus sex peptide receptor 0.024 0.0466 0.0466
Schistosoma mansoni nAChR subunit 0.0254 0.0497 0.116
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0254 0.0497 0.1851
Onchocerca volvulus 0.0189 0.0345 0.0669
Loa Loa (eye worm) voltage-gated potassium channel 0.0045 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0199 0.037 0.1366
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0254 0.0497 0.1851
Schistosoma mansoni peptide (allatostatin)-like receptor 0.024 0.0466 0.1085
Loa Loa (eye worm) acetylcholine receptor protein 0.0117 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Brugia malayi gonadotropin-releasing hormone receptor 2 0.024 0.0466 0.1732
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.024 0.0466 0.0466
Schistosoma mansoni vesicular amine transporter 0.0045 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0575 0.1247 0.4646
Loa Loa (eye worm) hypothetical protein 0.0137 0.0225 0.0823
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Echinococcus granulosus glycine receptor subunit beta 0.0254 0.0497 0.0497
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.024 0.0466 0.0466
Echinococcus granulosus voltage dependent calcium channel 0.0119 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus granulosus neuropeptide receptor A26 0.024 0.0466 0.0466
Brugia malayi neuropeptide F receptor 0.024 0.0466 0.1732
Echinococcus granulosus tachykinin peptides receptor 99D 0.024 0.0466 0.0466
Schistosoma mansoni neurotransmitter gated ion channel 0.0117 0.0177 0.041
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Echinococcus multilocularis allatostatin A receptor 0.024 0.0466 0.0466
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Onchocerca volvulus 0.024 0.0466 0.1153
Onchocerca volvulus 0.0254 0.0497 0.128
Schistosoma mansoni biogenic amine receptor 0.024 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.0254 0.0497 0.1842
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0254 0.0497 0.0497
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.024 0.0466 0.1085
Schistosoma mansoni integrin alpha 0.009 0.0114 0.0262
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0199 0.037 0.0862
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0254 0.0497 0.116
Brugia malayi hypothetical protein 0.024 0.0466 0.1732
Echinococcus multilocularis glycine receptor subunit beta 0.0254 0.0497 0.0497
Echinococcus granulosus tyrosine protein kinase Fyn 0.0185 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.0043 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.024 0.0466 0.1723
Schistosoma mansoni amine GPCR 0.024 0.0466 0.1085
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0117 0.0177 0.0177
Toxoplasma gondii PAN domain-containing protein 0.1887 0.431 1
Echinococcus multilocularis serotonin receptor 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0117 0.0177 0.0645
Schistosoma mansoni hypothetical protein 0.0199 0.037 0.0862
Onchocerca volvulus 0.024 0.0466 0.1153
Echinococcus granulosus tyrosine protein kinase Src42A 0.0185 0.0336 0.0336
Loa Loa (eye worm) TK protein kinase 0.0167 0.0294 0.1082
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0295 0.0593 0.2198
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0254 0.0497 0.0497
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0167 0.0294 0.0294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.024 0.0466 0.1085

Activities

Activity type Activity value Assay description Source Reference
Change of tumor area (functional) = 50 % Percentage change in tumor area in postmenopausal rat model at 11.5 mg/kg dose ChEMBL. 1895288
No. of tumors (functional) = 11 Final tumour number in postmenopausal rat model at 11.5 mg/kg dose ChEMBL. 1895288
No. of tumors (functional) = 34 Initial tumour number in postmenopausal rat model at 11.5 mg/kg dose ChEMBL. 1895288
Tumors with CR (functional) = 12 % Percentage complete remission of tumors in postmenopausal rat model at 11.5 mg/kg dose ChEMBL. 1895288
Tumors with CR (functional) = 24 % Percentage of unchanged tumour size in postmenopausal rat model at 11.5 mg/kg dose ChEMBL. 1895288
Tumors with CR (functional) = 29 % Percentage partial remission of tumors in postmenopausal rat model at 11.5 mg/kg dose ChEMBL. 1895288
Tumors with CR (functional) = 35 % Percentage of progressive tumors in postmenopausal rat model at 11.5 mg/kg dose ChEMBL. 1895288

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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