Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | caspase 3, apoptosis-related cysteine peptidase | Starlite/ChEMBL | No references |
Homo sapiens | SUMO1/sentrin specific peptidase 7 | Starlite/ChEMBL | No references |
Homo sapiens | SUMO/sentrin specific peptidase family member 8 | Starlite/ChEMBL | No references |
Homo sapiens | SUMO1/sentrin specific peptidase 6 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cell death protein 3 precursor | caspase 3, apoptosis-related cysteine peptidase | 277 aa | 253 aa | 38.7 % |
Plasmodium falciparum | sentrin-specific protease 1 | SUMO/sentrin specific peptidase family member 8 | 212 aa | 197 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.012 | 0.2633 | 0.2633 |
Echinococcus multilocularis | expressed conserved protein | 0.0163 | 0.616 | 0.616 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.1933 | 0.5 |
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.0111 | 0.1933 | 0.5 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.1933 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0111 | 0.1933 | 0.5 |
Echinococcus multilocularis | caspase | 0.012 | 0.2633 | 0.2633 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.012 | 0.2633 | 0.0868 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0111 | 0.1933 | 0.5 |
Loa Loa (eye worm) | Ulp1 protease | 0.0111 | 0.1933 | 0.5 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.1933 | 0.5 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0111 | 0.1933 | 0.1933 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0111 | 0.1933 | 0.1933 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.012 | 0.2633 | 0.0868 |
Echinococcus granulosus | expressed conserved protein | 0.0163 | 0.616 | 0.616 |
Echinococcus granulosus | caspase | 0.012 | 0.2633 | 0.2633 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.012 | 0.2633 | 0.2633 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 85 % | Activation of UTRN promoter in mouse H2K cells assessed as upregulation of UTRN production at 3 uM after 48 hrs by luciferase reporter linked assay | ChEMBL. | 21456623 |
IC50 (functional) | = 1.31 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] | ChEMBL. | No reference |
IC50 (functional) | = 1.76 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575] | ChEMBL. | No reference |
IC50 (functional) | = 1.81 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2582, AID2599] | ChEMBL. | No reference |
IC50 (functional) | = 2.27 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.