TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 611.81 | Formula: C39H49NO5
H donors: 0 H acceptors: 4 LogP: 7.28 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: COc1cccc2c1CCC(C2=O)Cc1ccncc1.CCC(=O)O[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C
InChi: 1S/C22H32O3.C17H17NO2/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3;1-20-16-4-2-3-15-14(16)6-5-13(17(15)19)11-12-7-9-18-10-8-12/h13,16-19H,4-12H2,1-3H3;2-4,7-10,13H,5-6,11H2,1H3/t16-,17-,18-,19-,21-,22-;/m0./s1
InChiKey: IGOBFPGMKSCLRQ-QZXDNJHYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	integrin alpha ps	0.0043	0.0005	0.0005
Echinococcus granulosus	neuropeptide receptor A26	0.024	0.0466	0.0466
Onchocerca volvulus		0.0189	0.0345	0.0669
Echinococcus granulosus	dro:myosuppressin receptor	0.024	0.0466	0.0466
Schistosoma mansoni	biogenic amine receptor	0.024	0.0466	0.1085
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0137	0.0225	0.0833
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0117	0.0177	0.0177
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.024	0.0466	0.0466
Echinococcus granulosus	tachykinin peptides receptor 99D	0.024	0.0466	0.0466
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.024	0.0466	0.1085
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.024	0.0466	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0183	0.0667
Echinococcus multilocularis	G protein coupled receptor 139	0.024	0.0466	0.0466
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0345	0.1271
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0167	0.0294	0.0294
Brugia malayi	SRC-1	0.0185	0.0336	0.1249
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0254	0.0497	0.116
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0014	0.0032
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Schistosoma mansoni	neuropeptide f receptor 76f	0.024	0.0466	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0225	0.0823
Brugia malayi	Protein kinase domain containing protein	0.03	0.0605	0.2252
Echinococcus granulosus	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Brugia malayi	follicle stimulating hormone receptor	0.024	0.0466	0.1732
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0137	0.0225	0.0833
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0185	0.0336	0.0336
Brugia malayi	hypothetical protein	0.0117	0.0177	0.0655
Onchocerca volvulus		0.0254	0.0497	0.128
Onchocerca volvulus		0.0189	0.0345	0.0669
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0254	0.0497	0.1851
Echinococcus granulosus	voltage gated potassium channel	0.0045	0.001	0.001
Echinococcus multilocularis	sex peptide receptor	0.024	0.0466	0.0466
Onchocerca volvulus		0.0989	0.2213	0.814
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.024	0.0466	0.1732
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.024	0.0466	0.0466
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0254	0.0497	0.0497
Echinococcus granulosus	shaker cognate	0.0045	0.001	0.001
Brugia malayi	Trypsin family protein	0.0199	0.037	0.1375
Echinococcus granulosus	potassium voltage gated channel protein	0.0045	0.001	0.001
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	sodium channel protein	0.0062	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0185	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Brugia malayi	jmjC domain containing protein	0.0096	0.0129	0.0474
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0185	0.0336	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.024	0.0466	0.1085
Echinococcus multilocularis	serotonin receptor	0.024	0.0466	0.0466
Echinococcus granulosus	integrin alpha ps	0.009	0.0114	0.0114
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.024	0.0466	0.0466
Onchocerca volvulus		0.0189	0.0345	0.0669
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0023	0.0078
Echinococcus multilocularis	Mastin	0.0199	0.037	0.037
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Echinococcus granulosus	g protein coupled receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	TK/ROR protein kinase	0.03	0.0605	0.2244
Brugia malayi	Cation transporter family protein	0.0254	0.0497	0.1851
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.0177	0.0655
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.0177	0.0655
Schistosoma mansoni	biogenic amine receptor	0.024	0.0466	0.1085
Loa Loa (eye worm)	ACC-1 protein	0.0254	0.0497	0.1842
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0254	0.0497	0.1842
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Echinococcus multilocularis	g protein coupled receptor	0.024	0.0466	0.0466
Schistosoma mansoni	nAChR subunit	0.0254	0.0497	0.116
Onchocerca volvulus		0.024	0.0466	0.1153
Brugia malayi	neuropeptide F receptor	0.024	0.0466	0.1732
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0045	0.001	0.001
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0185	0.0336	0.0336
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Echinococcus granulosus	7TM GPCR rhodopsin	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0023	0.0067
Onchocerca volvulus		0.024	0.0466	0.1153
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0526	0.1133	0.1133
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0199	0.037	0.037
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0162	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0254	0.0497	0.1851
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0119	0.0183	0.0183
Echinococcus multilocularis	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1248	0.2819	0.6595
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0137	0.0225	0.0833
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Mycobacterium ulcerans	hypothetical protein	0.0199	0.037	0.5
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0045	0.001	0.003
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Schistosoma mansoni	voltage-gated cation channel	0.0119	0.0183	0.0424
Echinococcus multilocularis	neuropeptide Y receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	TYRA-2 protein	0.024	0.0466	0.1723
Brugia malayi	Integrin alpha pat-2 precursor	0.009	0.0114	0.0417
Schistosoma mansoni	amine GPCR	0.024	0.0466	0.1085
Brugia malayi	CUB domain containing protein	0.006	0.0045	0.0161
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0185	0.0336	0.0336
Loa Loa (eye worm)	neuropeptide F receptor	0.024	0.0466	0.1723
Brugia malayi	Cation transporter family protein	0.0254	0.0497	0.1851
Onchocerca volvulus		0.0189	0.0345	0.0669
Onchocerca volvulus		0.1188	0.2678	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0199	0.037	0.0862
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.0083	0.0189
Onchocerca volvulus		0.0199	0.037	0.0771
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0185	0.0336	0.0336
Echinococcus multilocularis	transfer RNA-Gly	0.0045	0.001	0.001
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0254	0.0497	0.1851
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Schistosoma mansoni	opsin-like receptor	0.024	0.0466	0.1085
Brugia malayi	Trypsin-like protease protein 5	0.0199	0.037	0.1375
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0137	0.0225	0.0522
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Schistosoma mansoni	opsin-like receptor	0.024	0.0466	0.1085
Toxoplasma gondii	PAN domain-containing protein	0.1887	0.431	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0042	0.0002	0.0002
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0295	0.0593	0.5
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.0129	0.0129
Onchocerca volvulus		0.0181	0.0326	0.0597
Brugia malayi	G-protein coupled receptor	0.024	0.0466	0.1732
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0199	0.037	0.037
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0575	0.1247	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0225	0.0823
Echinococcus granulosus	somatostatin receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	integrin alpha 3	0.0043	0.0005	0.0005
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0117	0.0177	0.0177
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.024	0.0466	0.0466
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.024	0.0466	0.0466
Echinococcus granulosus	transmembrane protease serine 3	0.0199	0.037	0.037
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.024	0.0466	0.1085
Echinococcus granulosus	nAChR subunit	0.0137	0.0225	0.0225
Onchocerca volvulus		0.024	0.0466	0.1153
Schistosoma mansoni	voltage-gated potassium channel	0.0526	0.1133	0.2647
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0117	0.0177	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Echinococcus granulosus	glycine receptor subunit beta	0.0254	0.0497	0.0497
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0119	0.0183	0.0183
Echinococcus multilocularis	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0345	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0225	0.0823
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.024	0.0466	0.1085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Schistosoma mansoni	amine GPCR	0.024	0.0466	0.1085
Echinococcus granulosus	neuropeptide s receptor	0.024	0.0466	0.0466
Schistosoma mansoni	neuropeptide receptor	0.024	0.0466	0.1085
Echinococcus multilocularis	neuropeptide Y receptor	0.024	0.0466	0.0466
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Onchocerca volvulus		0.0189	0.0345	0.0669
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0148	0.0251	0.0251
Echinococcus granulosus	7tm_1 domain containing protein	0.024	0.0466	0.0466
Echinococcus multilocularis	g protein coupled receptor	0.024	0.0466	0.0466
Onchocerca volvulus		0.0189	0.0345	0.0669
Onchocerca volvulus		0.0189	0.0345	0.0669
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0345	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1247	0.4646
Brugia malayi	SEA domain containing protein	0.0176	0.0317	0.1176
Echinococcus granulosus	tyrosine protein kinase HCK	0.0148	0.0251	0.0251
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0458	0.0974	0.3626
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0043	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0045	0.001	0.0019
Onchocerca volvulus		0.024	0.0466	0.1153
Schistosoma mansoni	acetylcholine receptor-related	0.0117	0.0177	0.041
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus multilocularis	neuropeptides capa receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0119	0.0183	0.0183
Onchocerca volvulus		0.0295	0.0593	0.1661
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0254	0.0497	0.1851
Schistosoma mansoni	neuropeptide receptor	0.024	0.0466	0.1085
Schistosoma mansoni	nAChR subunit	0.0117	0.0177	0.041
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0345	0.1271
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Echinococcus granulosus	neuropeptide receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0254	0.0497	0.0497
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0045	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0225	0.0823
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0254	0.0497	0.0497
Schistosoma mansoni	tyrosine kinase	0.0185	0.0336	0.0782
Brugia malayi	Melatonin receptor type 1A	0.024	0.0466	0.1732
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Brugia malayi	Trypsin family protein	0.0199	0.037	0.1375
Brugia malayi	Muscle positioning protein 4	0.0181	0.0326	0.1212
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0254	0.0497	0.1851
Echinococcus multilocularis	serotonin receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0185	0.0336	0.0336
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0254	0.0497	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0254	0.0497	0.1842
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0575	0.1247	0.2915
Onchocerca volvulus		0.024	0.0466	0.1153
Schistosoma mansoni	neuropeptide receptor	0.024	0.0466	0.1085
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.008	0.0092	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0185	0.0336	0.0336
Onchocerca volvulus		0.0199	0.037	0.0771
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0199	0.037	0.0862
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0045	0.001	0.001
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.024	0.0466	0.1723
Schistosoma mansoni	vesicular amine transporter	0.0045	0.001	0.0019
Schistosoma mansoni	amine GPCR	0.024	0.0466	0.1085
Echinococcus multilocularis	neuropeptides capa receptor	0.024	0.0466	0.0466
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.024	0.0466	0.1085
Schistosoma mansoni	tyrosine kinase	0.0185	0.0336	0.0782
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0345	0.1271
Brugia malayi	hypothetical protein	0.0117	0.0177	0.0655
Schistosoma mansoni	biogenic amine (5HT) receptor	0.024	0.0466	0.1085
Echinococcus granulosus	c src tyrosine kinase	0.0042	0.0002	0.0002
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0167	0.0294	0.0294
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Loa Loa (eye worm)	hypothetical protein	0.1188	0.2678	1
Onchocerca volvulus		0.0189	0.0345	0.0669
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Echinococcus granulosus	orexin receptor type 2	0.024	0.0466	0.0466
Echinococcus granulosus	voltage dependent calcium channel	0.0119	0.0183	0.0183
Brugia malayi	Trypsin family protein	0.0199	0.037	0.1375
Schistosoma mansoni	myosin xvIII	0.024	0.0466	0.1085
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.024	0.0466	0.1085
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0185	0.0336	0.0336
Onchocerca volvulus		0.0199	0.037	0.0771
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0137	0.0225	0.0522
Loa Loa (eye worm)	TK protein kinase	0.0167	0.0294	0.1082
Onchocerca volvulus		0.0575	0.1247	0.4277
Echinococcus multilocularis	g protein coupled receptor	0.024	0.0466	0.0466
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.024	0.0466	0.1085
Loa Loa (eye worm)	hypothetical protein	0.005	0.0022	0.0064
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0162	0.0282	0.0282
Onchocerca volvulus		0.024	0.0466	0.1153
Echinococcus multilocularis	glycine receptor subunit beta	0.0254	0.0497	0.0497
Onchocerca volvulus		0.024	0.0466	0.1153
Brugia malayi	Tachykinin-like peptides receptor 99D	0.024	0.0466	0.1732
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0254	0.0497	0.0497
Echinococcus multilocularis	tissue type plasminogen activator	0.0295	0.0593	0.0593
Onchocerca volvulus	Putative nachr subunit	0.0254	0.0497	0.128
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0503	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus multilocularis	potassium voltage gated channel protein	0.0526	0.1133	0.1133
Brugia malayi	RE15519p	0.024	0.0466	0.1732
Echinococcus multilocularis	neuropeptide s receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.024	0.0466	0.0466
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0345	0.1271
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0167	0.0294	0.0294
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0254	0.0497	0.0497
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0254	0.0497	0.1851
Schistosoma mansoni	integrin alpha-ps	0.009	0.0114	0.0262
Echinococcus multilocularis	nAChR subunit	0.0254	0.0497	0.0497
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Schistosoma mansoni	hypothetical protein	0.024	0.0466	0.1085
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0254	0.0497	0.0497
Schistosoma mansoni	biogenic amine receptor	0.024	0.0466	0.1085
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.024	0.0466	0.1732
Schistosoma mansoni	neuropeptide F-like receptor	0.024	0.0466	0.1085
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0185	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Onchocerca volvulus		0.0254	0.0497	0.128
Echinococcus multilocularis	fmrfamide receptor	0.024	0.0466	0.0466
Echinococcus granulosus	neuropeptides capa receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	GABA receptor subunit	0.0137	0.0225	0.0823
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0227	0.0435	0.1015
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0254	0.0497	0.0497
Echinococcus granulosus	integrin alpha 3	0.0043	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0326	0.1203
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	glycoprotein Antigen 5	0.0199	0.037	0.037
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0119	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Schistosoma mansoni	serine-type protease inhibitor	0.1871	0.4273	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0117	0.0177	0.041
Schistosoma mansoni	growth hormone secretagogue receptor	0.024	0.0466	0.1085
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0254	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0254	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Brugia malayi	larval opioid receptor	0.024	0.0466	0.1732
Loa Loa (eye worm)	G-protein coupled receptor	0.024	0.0466	0.1723
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.024	0.0466	0.1085
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.024	0.0466	0.1732
Onchocerca volvulus		0.024	0.0466	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0345	0.1271
Brugia malayi	hypothetical protein	0.0199	0.037	0.1375
Echinococcus multilocularis	neuropeptide receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0254	0.0497	0.0497
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.024	0.0466	0.1085
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.024	0.0466	0.1085
Echinococcus multilocularis	orexin receptor type 2	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Onchocerca volvulus		0.0575	0.1247	0.4277
Onchocerca volvulus		0.024	0.0466	0.1153
Schistosoma mansoni	neurotransmitter gated ion channel	0.0137	0.0225	0.0522
Echinococcus multilocularis	voltage dependent calcium channel	0.0119	0.0183	0.0183
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0119	0.0183	0.0677
Plasmodium falciparum	cysteine repeat modular protein 1	0.0295	0.0593	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.024	0.0466	0.0466
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0254	0.0497	0.1851
Echinococcus multilocularis	allatostatin A receptor	0.024	0.0466	0.0466
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Schistosoma mansoni	hypothetical protein	0.0295	0.0593	0.1383
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0254	0.0497	0.0497
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Brugia malayi	putative neuropeptide receptor	0.024	0.0466	0.1732
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.024	0.0466	0.1085
Brugia malayi	G protein-coupled receptor	0.024	0.0466	0.1732
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0254	0.0497	0.0497
Echinococcus multilocularis	voltage dependent calcium channel	0.0119	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0225	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Loa Loa (eye worm)	TK protein kinase	0.0148	0.0251	0.092
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0254	0.0497	0.1851
Echinococcus granulosus	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Echinococcus granulosus	glycine receptor subunit beta	0.0254	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Echinococcus multilocularis	potassium voltage gated channel protein	0.0045	0.001	0.001
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1188	0.2678	0.6266
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Brugia malayi	Kringle domain containing protein	0.0295	0.0593	0.2207
Echinococcus multilocularis	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Echinococcus granulosus	tissue type plasminogen activator	0.0295	0.0593	0.0593
Echinococcus multilocularis	neuropeptide receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0295	0.0593	0.2198
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.024	0.0466	0.1723
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0119	0.0183	0.0424
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0176	0.0317	0.1166
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0185	0.0336	0.0336
Echinococcus granulosus	sex peptide receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	integrin alpha ps	0.009	0.0114	0.0114
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0345	0.1271
Echinococcus granulosus	potassium voltage gated channel protein	0.0526	0.1133	0.1133
Echinococcus granulosus	neuropeptide receptor	0.024	0.0466	0.0466
Brugia malayi	AKH receptor	0.024	0.0466	0.1732
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0185	0.0336	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.024	0.0466	0.0466
Echinococcus multilocularis	transmembrane protease serine 3	0.0199	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.0199	0.037	0.1366
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.024	0.0466	0.0466
Brugia malayi	hypothetical protein	0.0117	0.0177	0.0655
Echinococcus granulosus	tyrosine kinase	0.0167	0.0294	0.0294
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0254	0.0497	0.0497
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Onchocerca volvulus		0.0189	0.0345	0.0669
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0254	0.0497	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0199	0.037	0.1366
Loa Loa (eye worm)	ACC-1 protein	0.0254	0.0497	0.1842
Brugia malayi	Serotonin receptor	0.024	0.0466	0.1732
Loa Loa (eye worm)	integrin alpha pat-2	0.009	0.0114	0.0407
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0045	0.001	0.001
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.024	0.0466	0.1085
Loa Loa (eye worm)	calcium channel	0.0119	0.0183	0.0667
Echinococcus multilocularis	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0045	0.001	0.001
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0119	0.0183	0.0183
Echinococcus granulosus	tm gpcr rhodopsin	0.024	0.0466	0.0466
Echinococcus multilocularis	c src tyrosine kinase	0.0042	0.0002	0.0002
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0119	0.0183	0.0424
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0117	0.0177	0.0655
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0185	0.0336	0.0336
Echinococcus granulosus	nAChR subunit	0.0254	0.0497	0.0497
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0254	0.0497	0.0497
Echinococcus multilocularis	somatostatin receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0254	0.0497	0.0497
Brugia malayi	hypothetical protein	0.0117	0.0177	0.0655
Echinococcus multilocularis	neuropeptide FF receptor 2	0.024	0.0466	0.0466
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0254	0.0497	0.1842
Echinococcus multilocularis	voltage gated potassium channel	0.0045	0.001	0.001
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.024	0.0466	0.0466
Schistosoma mansoni	neuropeptide receptor	0.024	0.0466	0.1085
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Echinococcus granulosus	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0199	0.037	0.1366
Brugia malayi	Dopamine receptor protein 1	0.024	0.0466	0.1732
Loa Loa (eye worm)	SRC-1	0.0185	0.0336	0.1239
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Echinococcus granulosus	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0526	0.1133	0.4218
Echinococcus granulosus	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Echinococcus multilocularis	integrin alpha ps	0.009	0.0114	0.0114
Echinococcus granulosus	enteropeptidase	0.0199	0.037	0.037
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0254	0.0497	0.116
Echinococcus multilocularis	neuropeptide receptor A26	0.024	0.0466	0.0466
Schistosoma mansoni	neurotransmitter gated ion channel	0.0117	0.0177	0.041
Echinococcus granulosus	neuropeptide FF receptor 2	0.024	0.0466	0.0466
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0254	0.0497	0.0497
Brugia malayi	ORL1-like opioid receptor	0.024	0.0466	0.1732
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.024	0.0466	0.1723
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0254	0.0497	0.1851
Onchocerca volvulus		0.024	0.0466	0.1153
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	LGC-31 protein	0.0254	0.0497	0.1842
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0254	0.0497	0.0497
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0185	0.0336	0.0336
Brugia malayi	protein-tyrosine kinase	0.0167	0.0294	0.1091
Onchocerca volvulus	Neuropeptide F receptor homolog	0.024	0.0466	0.1153
Toxoplasma gondii	kringle domain-containing protein	0.0295	0.0593	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Echinococcus granulosus	tyrosine protein kinase Blk	0.0167	0.0294	0.0294
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0185	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0042	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Schistosoma mansoni	serine-type protease inhibitor	0.1871	0.4273	1
Echinococcus granulosus	serotonin receptor	0.024	0.0466	0.0466
Schistosoma mansoni	nAChR subunit	0.0117	0.0177	0.041
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0199	0.037	0.037
Echinococcus granulosus	neuropeptides capa receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	g-protein coupled receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	enteropeptidase	0.0199	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Onchocerca volvulus		0.0137	0.0225	0.019
Echinococcus granulosus	fmrfamide receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Schistosoma mansoni	nAChR subunit	0.0254	0.0497	0.116
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0019
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0254	0.0497	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Loa Loa (eye worm)	DOMON domain-containing protein	0.0176	0.0317	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Onchocerca volvulus		0.0176	0.0317	0.0557
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0045	0.001	0.001
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0526	0.1133	0.4224
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0137	0.0225	0.0833
Onchocerca volvulus		0.024	0.0466	0.1153
Brugia malayi	excitatory GABA receptor EXP-1A	0.0254	0.0497	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0046	0.0154
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0254	0.0497	0.116
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0254	0.0497	0.1842
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0117	0.0177	0.0177
Onchocerca volvulus		0.024	0.0466	0.1153
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.024	0.0466	0.0466
Schistosoma mansoni	adenoreceptor	0.024	0.0466	0.1085
Brugia malayi	hypothetical protein	0.0117	0.0177	0.0655
Echinococcus granulosus	peptide allatostatin:somatostatin	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	tm gpcr rhodopsin	0.024	0.0466	0.0466
Echinococcus multilocularis	potassium voltage gated channel protein	0.0045	0.001	0.001
Schistosoma mansoni	voltage-gated potassium channel	0.0526	0.1133	0.2647
Echinococcus multilocularis	nAChR subunit	0.0137	0.0225	0.0225
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0023	0.0067
Brugia malayi	Trypsin family protein	0.1188	0.2678	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Brugia malayi	Dopamine receptor	0.024	0.0466	0.1732
Onchocerca volvulus		0.0176	0.0317	0.0557
Echinococcus granulosus	alpha 1A adrenergic receptor	0.024	0.0466	0.0466
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0254	0.0497	0.1851
Echinococcus granulosus	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Brugia malayi	G-protein coupled receptor	0.024	0.0466	0.1732
Echinococcus multilocularis	glycine receptor subunit beta	0.0254	0.0497	0.0497
Schistosoma mansoni	alpha-1 adrenergic receptor	0.024	0.0466	0.1085
Loa Loa (eye worm)	trypsin family protein	0.0199	0.037	0.1366
Loa Loa (eye worm)	G-protein coupled receptor	0.024	0.0466	0.1723
Brugia malayi	hypothetical protein	0.024	0.0466	0.1732
Echinococcus multilocularis	fmrfamide receptor	0.024	0.0466	0.0466
Brugia malayi	Cation transporter family protein	0.0575	0.1247	0.4652
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0045	0.001	0.001
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0117	0.0177	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0199	0.037	0.1366
Echinococcus granulosus	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0254	0.0497	0.1842
Loa Loa (eye worm)	hypothetical protein	0.0199	0.037	0.1366
Echinococcus granulosus	biogenic amine 5HT receptor	0.024	0.0466	0.0466
Onchocerca volvulus		0.0176	0.0317	0.0557
Brugia malayi	neuropeptide F receptor	0.024	0.0466	0.1732
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Entamoeba histolytica	protein kinase, putative	0.0148	0.0251	1
Onchocerca volvulus		0.024	0.0466	0.1153
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.024	0.0466	0.1153
Onchocerca volvulus		0.0575	0.1247	0.4277
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.024	0.0466	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0117	0.0177	0.0177
Echinococcus granulosus	G protein coupled receptor 139	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0345	0.1271
Schistosoma mansoni	hypothetical protein	0.024	0.0466	0.1085
Onchocerca volvulus		0.0199	0.037	0.0771
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0117	0.0177	0.0655
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.0129	0.0129
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0575	0.1247	0.4646
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0023	0.0078
Echinococcus granulosus	neuropeptide Y receptor	0.024	0.0466	0.0466
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0167	0.0294	0.0294
Schistosoma mansoni	nAChR subunit	0.0254	0.0497	0.116
Onchocerca volvulus		0.024	0.0466	0.1153
Loa Loa (eye worm)	acetylcholine receptor protein	0.0117	0.0177	0.0645
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0199	0.037	0.0862
Schistosoma mansoni	amine GPCR	0.024	0.0466	0.1085
Toxoplasma gondii	PAN domain-containing protein	0.1887	0.431	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0014	0.0032
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Echinococcus granulosus	Mastin	0.0199	0.037	0.037
Schistosoma mansoni	hypothetical protein	0.024	0.0466	0.1085
Schistosoma mansoni	histamine h1 receptor	0.024	0.0466	0.1085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.024	0.0466	0.0466
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Brugia malayi	sulfakinin receptor protein	0.024	0.0466	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0345	0.1271
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Schistosoma mansoni	opsin-like receptor	0.024	0.0466	0.1085
Echinococcus granulosus	biogenic amine 5HT receptor	0.024	0.0466	0.0466
Schistosoma mansoni	hypothetical protein	0.0199	0.037	0.0862
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0345	0.1271
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0254	0.0497	0.1851
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Schistosoma mansoni	amine GPCR	0.024	0.0466	0.1085
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0019
Onchocerca volvulus		0.024	0.0466	0.1153
Loa Loa (eye worm)	PAN domain-containing protein	0.0189	0.0345	0.1271
Brugia malayi	Serotonin receptor	0.024	0.0466	0.1732
Schistosoma mansoni	integrin alpha	0.009	0.0114	0.0262
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0119	0.0183	0.0183
Onchocerca volvulus		0.024	0.0466	0.1153
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Onchocerca volvulus		0.0189	0.0345	0.0669
Schistosoma mansoni	nAChR subunit	0.0254	0.0497	0.116
Echinococcus multilocularis	dro:myosuppressin receptor	0.024	0.0466	0.0466
Echinococcus granulosus	neuropeptide Y receptor	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0177	0.0645
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0254	0.0497	0.1851
Schistosoma mansoni	biogenic amine (5HT) receptor	0.024	0.0466	0.1085
Echinococcus multilocularis	integrin alpha ps	0.0043	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.1188	0.2678	1
Schistosoma mansoni	nAChR subunit	0.0254	0.0497	0.116
Loa Loa (eye worm)	melatonin receptor type 1A	0.024	0.0466	0.1723
Echinococcus multilocularis	glycoprotein Antigen 5	0.0199	0.037	0.037
Loa Loa (eye worm)	voltage-gated potassium channel	0.0045	0.001	0.0019
Echinococcus multilocularis	shaker cognate	0.0045	0.001	0.001
Echinococcus granulosus	hypothetical protein	0.024	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0199	0.037	0.1375
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0119	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.006	0.0045	0.0151
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0199	0.037	0.037
Brugia malayi	GnHR receptor homolog	0.024	0.0466	0.1732
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0062	0.0049	0.0049
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0045	0.001	0.003
Onchocerca volvulus		0.0137	0.0225	0.019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.024	0.0466	0.1085
Echinococcus granulosus	g protein coupled receptor	0.024	0.0466	0.0466
Schistosoma mansoni	nAChR subunit	0.0254	0.0497	0.116
Schistosoma mansoni	hypothetical protein	0.024	0.0466	0.1085
Echinococcus granulosus	g-protein coupled receptor	0.024	0.0466	0.0466
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0254	0.0497	0.116
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0225	0.0823
Leishmania major	hypothetical protein, conserved	0.0295	0.0593	0.5
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0117	0.0177	0.041
Onchocerca volvulus		0.0199	0.037	0.0771
Brugia malayi	putative neuropeptide receptor NPR1	0.024	0.0466	0.1732
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0019
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0254	0.0497	0.1851
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Schistosoma mansoni	neuropeptide F-like receptor	0.024	0.0466	0.1085
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0199	0.037	0.0862
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0019
Brugia malayi	PAN domain containing protein	0.0189	0.0345	0.128
Onchocerca volvulus		0.0176	0.0317	0.0557
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.024	0.0466	0.0466
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Onchocerca volvulus		0.024	0.0466	0.1153
Schistosoma mansoni	integrin alpha-ps	0.0047	0.0014	0.0027
Schistosoma mansoni	hypothetical protein	0.0199	0.037	0.0862
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0117	0.0177	0.0645
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.024	0.0466	0.1732
Loa Loa (eye worm)	neuropeptide F receptor	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.006	0.0045	0.0151
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0254	0.0497	0.0497
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0117	0.0177	0.0655
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Schistosoma mansoni	nAChR subunit	0.0254	0.0497	0.116
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0185	0.0336	0.0336
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.024	0.0466	0.0466
Schistosoma mansoni	hypothetical protein	0.0043	0.0005	0.0007
Schistosoma mansoni	hypothetical protein	0.0176	0.0317	0.0737
Echinococcus granulosus	g protein coupled receptor	0.024	0.0466	0.0466
Brugia malayi	Dopamine receptor protein 2	0.024	0.0466	0.1732
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0117	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0225	0.0823
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.001	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Schistosoma mansoni	cercarial elastase (S01 family)	0.0199	0.037	0.0862
Echinococcus granulosus	potassium voltage gated channel protein	0.0045	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0185	0.0336	0.0336
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0254	0.0497	0.0497
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0254	0.0497	0.0497
Onchocerca volvulus		0.0189	0.0345	0.0669
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	hypothetical protein	0.024	0.0466	0.1723
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.024	0.0466	0.1723
Trypanosoma cruzi	hypothetical protein, conserved	0.0295	0.0593	1
Schistosoma mansoni	integrin alpha-4	0.0383	0.0799	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0225	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0497	0.1842
Echinococcus multilocularis	G-protein coupled receptor, putative	0.024	0.0466	0.0466
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0254	0.0497	0.1851
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0254	0.0497	0.1842
Echinococcus granulosus	allatostatin A receptor	0.024	0.0466	0.0466
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0199	0.037	0.0862
Brugia malayi	G protein-coupled receptor F59B2.13	0.024	0.0466	0.1732
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0042	0.0002	0.0002
Onchocerca volvulus		0.0254	0.0497	0.128

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1744469

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1515592