Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0256 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0256 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0245 | 0.1316 | 0.1316 |
Echinococcus multilocularis | serotonin transporter | 0.0245 | 0.1316 | 1 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0245 | 0.1316 | 0.1316 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 0.0256 | 0.0407 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | serotonin transporter b | 0.0245 | 0.1316 | 0.1316 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0299 | 0.1702 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0256 | 0.0407 |
Echinococcus granulosus | serotonin transporter | 0.0245 | 0.1316 | 1 |
Toxoplasma gondii | hexokinase | 0.0096 | 0.0256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0038 | 0.0038 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.0256 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1316 | 0.1316 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0824 | 0.5449 | 0.5449 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0299 | 0.1702 | 0.5 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0824 | 0.5449 | 0.5449 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0278 | 0.1552 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.0256 | 0.1944 | |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0256 | 0.0256 |
Onchocerca volvulus | 0.0245 | 0.1316 | 1 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0245 | 0.1316 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1316 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1316 | 0.1316 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0256 | 0.0407 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0245 | 0.1316 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0211 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0211 | 0.0211 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0245 | 0.1316 | 0.1316 |
Onchocerca volvulus | 0.0096 | 0.0256 | 0.1944 | |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0211 | 0.0211 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 0.0256 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0747 | 0.4901 | 0.4901 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0256 | 0.0256 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0245 | 0.1316 | 1 |
Onchocerca volvulus | 0.0096 | 0.0256 | 0.1944 | |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0256 | 0.0407 |
Brugia malayi | Serine carboxypeptidase S28 family protein | 0.009 | 0.0211 | 0.0211 |
Brugia malayi | hexokinase | 0.0096 | 0.0256 | 0.0256 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.0256 | 0.0407 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0824 | 0.5449 | 0.5449 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0256 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0256 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0824 | 0.5449 | 0.5449 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.0256 | 0.0407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 10 uM | Activation of His-tagged recombinant glucokinase expressed in Escherichia coli using [14C]-glucose substrate by spectrophotometrically | ChEMBL. | 21515051 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.