Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5155 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0925 | 0.0925 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.7041 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.1313 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5155 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5155 | 0.5155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5155 | 0.5155 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.314 | 0.6092 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5155 | 0.5155 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0925 | 0.1794 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1721 | 0.1721 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0925 | 0.1313 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.468 | 0.9079 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5155 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5155 | 0.7321 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.