TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.386 | Formula: C19H19N5O2
H donors: 2 H acceptors: 4 LogP: 2.44 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ncc(cc1c1cccc2c1nnc(c2N)C(=O)NC1CC1)C
InChi: 1S/C19H19N5O2/c1-10-8-14(19(26-2)21-9-10)12-4-3-5-13-15(20)17(24-23-16(12)13)18(25)22-11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H2,20,23)(H,22,25)
InChiKey: QPBUEBDNKGGQCP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	GTPase activating protein	0.0048	0.323	0.3235
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0015	0.0538	0.0539
Echinococcus granulosus	SH2 motif	0.0048	0.323	0.323
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0538	0.0539
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Echinococcus granulosus	integrin linked protein kinase	0.0083	0.6069	0.6069
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0083	0.6069	0.6069
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0039	0.2479	0.2483
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.6069	1
Echinococcus granulosus	c src tyrosine kinase	0.0131	0.9985	0.9985
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0083	0.6069	0.6069
Echinococcus granulosus	epidermal growth factor receptor	0.0083	0.6069	0.6069
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0054	0.3715	0.3721
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus granulosus	activated cdc42 kinase 1	0.0083	0.6069	0.6069
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0048	0.323	0.3235
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0131	0.9985	0.9985
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0048	0.323	0.3235
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0083	0.6069	1
Schistosoma mansoni	protein kinase	0.0083	0.6084	0.6093
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0131	0.9985	0.9985
Onchocerca volvulus		0.0083	0.6069	0.5854
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0015	0.0538	0.0539
Leishmania major	protein kinase, putative	0.0083	0.6084	1
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Schistosoma mansoni	shc transforming protein	0.0048	0.323	0.3235
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	protein kinase C gamma type	0.0049	0.3266	0.3266
Entamoeba histolytica	protein kinase, putative	0.0048	0.3245	0.325
Echinococcus multilocularis	RNA directed DNA polymerase	0.0039	0.2479	0.2483
Schistosoma mansoni	protein kinase	0.0083	0.6084	0.6093
Schistosoma mansoni	growth factor receptor-bound protein	0.0048	0.323	0.3235
Brugia malayi	Tyrosine-protein kinase PR2	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0538	0.0539
Loa Loa (eye worm)	serine/threonine protein kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0015	0.0538	0.0539
Schistosoma mansoni	nAChR subunit	0.0015	0.0538	0.0539
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0538	0.0539
Echinococcus multilocularis	NCK adaptor protein	0.0048	0.323	0.3235
Brugia malayi	Tensin	0.0048	0.323	0.3235
Echinococcus multilocularis	protein kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Echinococcus multilocularis	N chimaerin	0.0054	0.3715	0.3721
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Schistosoma mansoni	hypothetical protein	0.0048	0.323	0.3235
Echinococcus multilocularis	signal transduction protein lnk realted	0.0048	0.323	0.3235
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0048	0.323	0.3235
Entamoeba histolytica	receptor protein kinase, putative	0.0083	0.6069	0.6078
Echinococcus multilocularis	SH2 motif	0.0048	0.323	0.3235
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus granulosus	RNA directed DNA polymerase	0.0039	0.2479	0.2479
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0048	0.323	0.3235
Brugia malayi	SH2 domain containing protein	0.0048	0.323	0.3235
Brugia malayi	Tyrosine-protein kinase abl-1	0.0131	0.9985	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0083	0.6069	0.6078
Brugia malayi	hypothetical protein	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	protein kinase	0.0083	0.6069	0.6078
Brugia malayi	hypothetical protein	0.0083	0.6069	0.6078
Schistosoma mansoni	atypical protein kinase C	0.0014	0.0485	0.0486
Echinococcus granulosus	signal transduction protein lnk realted	0.0048	0.323	0.323
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.6069	1
Brugia malayi	Variant SH3 domain containing protein	0.0048	0.323	0.3235
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0083	0.6069	0.5854
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0048	0.323	0.3235
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Echinococcus granulosus	SH2 domain containing protein 7	0.0048	0.323	0.323
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	SH2 domain-containing protein	0.0048	0.323	0.3235
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0538	0.0539
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0016	0.0586	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Onchocerca volvulus		0.0083	0.6069	0.5854
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0083	0.6069	0.6078
Brugia malayi	integrin-linked kinase	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0083	0.6069	0.5854
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0015	0.0538	0.0539
Loa Loa (eye worm)	TK/FER protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0083	0.6069	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0131	0.9985	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0083	0.6069	0.6078
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0083	0.6069	0.6069
Echinococcus granulosus	nAChR subunit	0.0015	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0538	0.0538
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0048	0.323	0.3235
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0048	0.323	0.323
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0054	0.3715	0.3721
Schistosoma mansoni	serine/threonine RGC	0.0083	0.6069	0.6078
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0083	0.6069	0.9976
Onchocerca volvulus		0.0048	0.323	0.2849
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0538	0.0539
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0538	0.0538
Schistosoma mansoni	tensin	0.0048	0.323	0.3235
Echinococcus granulosus	ephrin type A receptor 4 A	0.0083	0.6069	0.6069
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0131	0.9985	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0048	0.323	0.3235
Loa Loa (eye worm)	TK/FER protein kinase	0.0083	0.6069	0.6078
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0083	0.6069	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0083	0.6069	0.9976
Echinococcus granulosus	NCK adaptor protein	0.0048	0.323	0.323
Echinococcus multilocularis		0.0048	0.323	0.3235
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0131	0.9985	1
Brugia malayi	SH2 domain containing protein	0.0048	0.323	0.3235
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0538	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0083	0.6069	0.6078
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0054	0.3715	0.3721
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK/ALK protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0131	0.9985	1
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0083	0.6069	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Onchocerca volvulus		0.0083	0.6069	0.5854
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Toxoplasma gondii	STE kinase	0.0083	0.6069	0.9976
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.6069	1
Brugia malayi	Sex muscle abnormal protein 5	0.0048	0.323	0.3235
Brugia malayi	Cation transporter family protein	0.0015	0.0538	0.0539
Echinococcus multilocularis	tensin	0.0048	0.323	0.3235
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0538	0.0539
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0538	0.0539
Echinococcus granulosus	tyrosine protein kinase HCK	0.0083	0.6069	0.6069
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0083	0.6069	0.9976
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Loa Loa (eye worm)	TK/RYK protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	receptor type guanylyl cyclase	0.0083	0.6069	0.6069
Giardia lamblia	Protein 21.1	0.0083	0.6069	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.3752	0.3757
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0083	0.6069	0.6078
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0054	0.3715	0.3721
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0131	0.9985	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Brugia malayi	SH2 domain containing protein	0.0048	0.323	0.3235
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Echinococcus multilocularis	nAChR subunit	0.0015	0.0538	0.0539
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0048	0.323	0.323
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0131	0.9985	0.9985
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0015	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Echinococcus granulosus	tyrosine protein kinase csk	0.0083	0.6069	0.6069
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Brugia malayi	protein kinase C II.	0.0016	0.0586	0.0587
Echinococcus granulosus	tyrosine protein kinase csk	0.0083	0.6069	0.6069
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0083	0.6069	0.6078
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.004	0.2595	0.2599
Entamoeba histolytica	tyrosin kinase, putative	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0083	0.6069	0.5854
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0083	0.6069	0.6078
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0538	0.0539
Echinococcus multilocularis	tyrosine kinase	0.0131	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Loa Loa (eye worm)	STAT protein	0.0048	0.323	0.3235
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0131	0.9985	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	SH2 motif	0.0048	0.323	0.3235
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0083	0.6069	0.6078
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0048	0.323	0.3235
Schistosoma mansoni	nAChR subunit	0.0015	0.0538	0.0539
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0538	0.0539
Entamoeba histolytica	serine/threonine kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0538	0.0539
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	integrin linked protein kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.6069	1
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0538	0.0538
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0538	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0131	0.9985	0.9985
Echinococcus multilocularis	c src tyrosine kinase	0.0131	0.9985	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0048	0.323	0.3235
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Entamoeba histolytica	serine/threonine kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK/EPH protein kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0586	0.0587
Brugia malayi	hypothetical protein	0.0048	0.323	0.3235
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0083	0.6069	0.6078
Echinococcus multilocularis	epidermal growth factor receptor	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine protein kinase shark	0.0131	0.9985	0.9985
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0538	0.0539
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0131	0.9985	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Schistosoma mansoni	tensin-related	0.0048	0.323	0.3235
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0131	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0538	0.0539
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0538	0.0539
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0048	0.323	0.323
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0083	0.6069	0.6078
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0048	0.323	0.3235
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Onchocerca volvulus		0.0131	0.9985	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0083	0.6069	0.6069
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	protein kinase	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0048	0.323	0.2849
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	SH2A	0.0048	0.323	0.3235
Schistosoma mansoni	signal transduction protein lnk-related	0.0048	0.323	0.3235
Schistosoma mansoni	ephrin receptor	0.0083	0.6069	0.6078
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0089	0.6554	0.6564
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0083	0.6069	0.6078
Loa Loa (eye worm)	SRC-1	0.0131	0.9985	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0083	0.6069	1
Brugia malayi	C-terminal src kinase protein 1	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0048	0.323	0.3235
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0538	0.0539
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Brugia malayi	Variant SH3 domain containing protein	0.0048	0.323	0.3235
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0048	0.323	0.3235
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	nck2/grb4	0.0048	0.323	0.3235
Onchocerca volvulus		0.0083	0.6069	0.5854
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0538	0.0538
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0538	0.0538
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0015	0.0538	0.0539
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0131	0.9985	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0083	0.6084	0.6093
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	protein kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	tensin-related	0.0048	0.323	0.3235
Echinococcus multilocularis	tyrosine kinase	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0048	0.323	0.2849
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK/DDR protein kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	LGC-31 protein	0.0015	0.0538	0.0539
Loa Loa (eye worm)	TK/ROR protein kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0083	0.6069	0.6078
Brugia malayi	Variant SH3 domain containing protein	0.0054	0.3715	0.3721
Brugia malayi	SH2 domain containing protein	0.0131	0.9985	1
Echinococcus granulosus	tensin	0.0048	0.323	0.323
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0538	0.0539
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0048	0.323	0.2849
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0131	0.9985	0.9985
Loa Loa (eye worm)	TK/FER protein kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus granulosus	SHC transforming protein 3	0.0048	0.323	0.323
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2965	0.2969
Schistosoma mansoni	protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase shark	0.0131	0.9985	1
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	SH2 domain containing protein 7	0.0048	0.323	0.3235
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0083	0.6084	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0083	0.6069	0.6078
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0083	0.6069	0.6069
Brugia malayi	Cation transporter family protein	0.0015	0.0538	0.0539
Schistosoma mansoni	tyrosine kinase	0.0131	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0048	0.323	0.3235
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Trichomonas vaginalis	TK family protein kinase	0.0083	0.6069	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0015	0.0538	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0083	0.6069	0.6069
Echinococcus multilocularis	FL cytokine receptor	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.6069	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0083	0.6069	0.6069
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0083	0.6069	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	protein kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	protein kinase	0.0083	0.6084	0.6093
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Brugia malayi	Variant SH3 domain containing protein	0.0049	0.3331	0.3336
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0131	0.9985	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0538	0.0538
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0055	0.3752	0.3757
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	protein kinase c iota type	0.0014	0.0485	0.0486
Echinococcus granulosus	protein tyrosine kinase	0.0083	0.6069	0.6069
Loa Loa (eye worm)	TK/FER protein kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0131	0.9985	1
Brugia malayi	SH2 domain containing protein	0.0048	0.323	0.3235
Echinococcus multilocularis	tyrosine protein kinase csk	0.0083	0.6069	0.6078
Schistosoma mansoni	hypothetical protein	0.0048	0.323	0.3235
Echinococcus multilocularis	epidermal growth factor receptor	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0083	0.6069	0.6078
Brugia malayi	Cation transporter family protein	0.0015	0.0538	0.0539
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Echinococcus granulosus	hypothetical protein	0.0048	0.323	0.323
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0131	0.9985	1
Brugia malayi	Guanylyl cyclase protein 23	0.0083	0.6069	0.6078
Entamoeba histolytica	tyrosin kinase, putative	0.0083	0.6069	0.6078
Entamoeba histolytica	serine/threonine kinase, putative	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Brugia malayi	Protein kinase c protein 2	0.0046	0.308	0.3085
Echinococcus granulosus	tyrosine protein kinase Srms	0.0131	0.9985	0.9985
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0131	0.9985	0.9985
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Echinococcus multilocularis	activated cdc42 kinase 1	0.0083	0.6069	0.6078
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0083	0.6084	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0131	0.9985	1
Schistosoma mansoni	vav2	0.0054	0.3715	0.3721
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0015	0.0538	0.0539
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0538	0.0539
Echinococcus multilocularis	protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0131	0.9985	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0131	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	transfer RNA-Thr	0.0083	0.6069	0.6078
Brugia malayi	protein-tyrosine kinase	0.0131	0.9985	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.6069	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0048	0.323	0.323
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0131	0.9985	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0538	0.0538
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0015	0.0538	0.0539
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0083	0.6069	0.6069
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine protein kinase	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0083	0.6069	0.5854
Entamoeba histolytica	ankyrin repeat protein	0.0083	0.6069	0.6078
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0048	0.323	0.2849
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	protein tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0015	0.0538	0.0539
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0538	0.0539
Echinococcus granulosus	SH2 motif	0.0048	0.323	0.323
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0131	0.9985	1
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Entamoeba histolytica	tyrosin kinase, putative	0.0083	0.6069	0.6078
Schistosoma mansoni	suppressor of cytokine signaling	0.0048	0.323	0.3235
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0131	0.9985	1
Echinococcus multilocularis	insulin receptor	0.0083	0.6069	0.6078
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0048	0.323	0.2849
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase csk	0.0083	0.6069	0.6078
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0083	0.6069	0.6069
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0015	0.0538	0.0539
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0083	0.6084	0.6084
Echinococcus granulosus	expressed conserved protein	0.0048	0.323	0.323
Echinococcus multilocularis	tensin	0.0048	0.323	0.3235
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	STE family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	hypothetical protein	0.0083	0.6069	0.6078
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0131	0.9985	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0083	0.6069	0.6078
Trypanosoma brucei	Pseudokinase, putative	0.0083	0.6069	0.9976
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0538	0.0539
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0048	0.323	0.3235
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine kinase	0.0131	0.9985	0.9985
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0083	0.6069	0.6078
Plasmodium falciparum	protein kinase, putative	0.0083	0.6084	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0083	0.6069	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0538	0.0539
Brugia malayi	SRC-1	0.0131	0.9985	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0048	0.323	0.3235
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Loa Loa (eye worm)	TK/FAK protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0083	0.6069	0.6069
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Schistosoma mansoni	ephrin receptor	0.0083	0.6069	0.6078
Echinococcus granulosus	epidermal growth factor receptor	0.0083	0.6069	0.6069
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0538	0.0539
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0083	0.6069	0.6069
Onchocerca volvulus		0.0083	0.6069	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0048	0.323	0.3235
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0015	0.0538	0.0539
Giardia lamblia	Kinase, NEK	0.0083	0.6069	0.5
Echinococcus granulosus	protein kinase c epsilon type	0.0016	0.0586	0.0586
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0538	0.0538
Schistosoma mansoni	protein kinase	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.6069	0.6078
Toxoplasma gondii	protein kinase	0.0083	0.6069	0.9976
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0083	0.6069	0.6078
Brugia malayi	ephrin receptor 1 precursor	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0538	0.0539
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6084	0.6093
Schistosoma mansoni	nAChR subunit	0.0015	0.0538	0.0539
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0131	0.9985	1
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK protein kinase	0.0131	0.9985	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0048	0.323	0.3235
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine kinase	0.0131	0.9985	0.9985
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0538	0.0539
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0538	0.0538
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0048	0.323	0.3235
Schistosoma mansoni	protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	activated cdc42 kinase 1	0.0083	0.6069	0.6069
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0083	0.6069	0.6078
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0083	0.6084	1
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0538	0.0538
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0538	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK/Met protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	protein tyrosine kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.3752	0.3757
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0054	0.3715	0.3715
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0131	0.9985	1
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0048	0.3245	0.325
Entamoeba histolytica	ankyrin repeat protein	0.0083	0.6069	0.6078
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0083	0.6069	0.9976
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Brugia malayi	SH2 domain containing protein	0.0048	0.323	0.3235
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0083	0.6069	0.6069
Trichomonas vaginalis	protein kinase atn1, putative	0.0083	0.6069	1
Echinococcus granulosus	tyrosine protein kinase	0.0083	0.6069	0.6069
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	SH2 domain-containing protein	0.0048	0.323	0.3235
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.6554	0.6564
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0048	0.323	0.3235
Giardia lamblia	Kinase	0.0083	0.6069	0.5
Schistosoma mansoni	adapter molecule crk	0.0048	0.323	0.3235
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0048	0.323	0.323
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	protein kinase c epsilon type	0.0016	0.0586	0.0587
Echinococcus granulosus	kinase suppressor of Ras 1	0.0083	0.6069	0.6069
Schistosoma mansoni	nAChR subunit	0.0015	0.0538	0.0539
Schistosoma mansoni	tyrosine kinase	0.0131	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	cysteine surface protein, putative	0.0083	0.6069	0.6078
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.6069	1
Echinococcus granulosus	activin receptor type	0.0083	0.6084	0.6084
Entamoeba histolytica	hypothetical protein	0.0083	0.6069	0.6078
Entamoeba histolytica	tyrosin kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0131	0.9985	1
Echinococcus multilocularis	SHC transforming protein 3	0.0048	0.323	0.3235
Entamoeba histolytica	serine/threonine kinase, putative	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0131	0.9985	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0083	0.6069	0.6078
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0083	0.6069	0.9976
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0015	0.0538	0.0539
Entamoeba histolytica	hypothetical protein, conserved	0.0083	0.6069	0.6078
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Schistosoma mansoni	tensin	0.0048	0.323	0.3235
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0131	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.323	0.3235
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0131	0.9985	0.9985
Echinococcus multilocularis	serine threonine protein kinase	0.0049	0.3266	0.3271
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0083	0.6069	0.6078
Schistosoma mansoni	nAChR subunit	0.0015	0.0538	0.0539
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0083	0.6069	0.6078
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Loa Loa (eye worm)	TK/FER protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	raf serine:threonine protein kinase	0.0089	0.6554	0.6554
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0083	0.6069	0.6078
Plasmodium vivax	protein kinase, putative	0.0083	0.6069	0.5
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Brugia malayi	SH2 domain containing protein	0.0048	0.323	0.3235
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trypanosoma brucei	protein kinase, putative	0.0083	0.6084	1
Trichomonas vaginalis	CAMK family protein kinase	0.0083	0.6069	1
Giardia lamblia	Kinase, NEK	0.0083	0.6069	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0131	0.9985	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0083	0.6069	0.6069
Onchocerca volvulus	Tyrosine kinase homolog	0.0083	0.6069	0.5854
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0039	0.2479	0.2483
Echinococcus granulosus	Protein kinase C brain isozyme	0.0055	0.3752	0.3752
Brugia malayi	hypothetical protein	0.0131	0.9985	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0048	0.323	0.3235
Brugia malayi	Receptor family ligand binding region containing protein	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus granulosus	protein kinase	0.0083	0.6069	0.6069
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0048	0.323	0.323
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0083	0.6069	0.6078
Brugia malayi	SH2 domain containing protein	0.0048	0.323	0.3235
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0048	0.323	0.3235
Onchocerca volvulus		0.0131	0.9985	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Echinococcus granulosus	growth factor receptor bound protein 2	0.0048	0.323	0.323
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0049	0.3331	0.3336
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0048	0.323	0.3235
Entamoeba histolytica	receptor protein kinase, putative	0.0083	0.6069	0.6078
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0015	0.0538	0.0539
Trichomonas vaginalis	AGC family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	tensin	0.0048	0.323	0.3235
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0015	0.0538	0.0539
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0083	0.6069	0.6078
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0083	0.6084	1
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0083	0.6069	0.6078
Brugia malayi	SH2 domain containing protein	0.0131	0.9985	1
Brugia malayi	Protein kinase domain containing protein	0.0131	0.9985	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0048	0.323	0.323
Echinococcus multilocularis	tyrosine protein kinase	0.0083	0.6069	0.6078
Brugia malayi	RhoGAP domain containing protein	0.0054	0.3715	0.3721
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	insulin receptor	0.0083	0.6069	0.6069
Brugia malayi	Protein kinase domain containing protein	0.0131	0.9985	1
Echinococcus granulosus	N chimaerin	0.0054	0.3715	0.3715
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	protein kinase, putative	0.0083	0.6069	0.6078
Loa Loa (eye worm)	TK/ACK protein kinase	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0131	0.9985	1
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0015	0.0538	0.0539
Onchocerca volvulus		0.0048	0.323	0.2849
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Entamoeba histolytica	serine/threonine kinase, putative	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0048	0.323	0.2849
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0538	0.0539
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0131	0.9985	0.9985
Echinococcus granulosus	natriuretic peptide receptor 1	0.0083	0.6069	0.6069
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0083	0.6069	0.5854
Schistosoma mansoni	suppressor of cytokine signaling	0.0048	0.323	0.3235
Loa Loa (eye worm)	hypothetical protein	0.0131	0.9985	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0083	0.6069	0.6078
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0083	0.6069	0.6078
Onchocerca volvulus		0.0131	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0083	0.6069	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0083	0.6069	0.6069
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0083	0.6069	0.6078
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0131	0.9985	0.9985
Brugia malayi	Raf kinase	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine kinase	0.0083	0.6069	0.6069
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Brugia malayi	Protein kinase domain containing protein	0.0131	0.9985	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Onchocerca volvulus		0.0131	0.9985	1
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0131	0.9985	1
Echinococcus granulosus	protein kinase c iota type	0.0014	0.0485	0.0485
Echinococcus granulosus	tyrosine protein kinase csk	0.0083	0.6069	0.6069
Echinococcus multilocularis	heat shock protein 70	0.0083	0.6069	0.6078
Entamoeba histolytica	tyrosine kinase, putative	0.0083	0.6069	0.6078
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0083	0.6069	0.6069
Echinococcus granulosus	tyrosine protein kinase pr2	0.0083	0.6069	0.6069
Schistosoma mansoni	nAChR subunit	0.0015	0.0538	0.0539
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Schistosoma mansoni	tyrosine kinase	0.0083	0.6069	0.6078
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0015	0.0538	0.0539
Brugia malayi	Protein kinase domain containing protein	0.0083	0.6069	0.6078
Schistosoma mansoni	nAChR subunit	0.0015	0.0538	0.0539
Brugia malayi	Protein kinase domain containing protein	0.0131	0.9985	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0015	0.0538	0.0538
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0048	0.323	0.323
Loa Loa (eye worm)	TK/INSR protein kinase	0.0083	0.6069	0.6078
Entamoeba histolytica	SH2 domain containing protein	0.0048	0.323	0.3235
Loa Loa (eye worm)	TK protein kinase	0.0083	0.6069	0.6078
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0131	0.9985	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0015	0.0538	0.0539
Echinococcus multilocularis	activin receptor type	0.0083	0.6084	0.6093
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	SH2 motif	0.0048	0.323	0.3235
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0131	0.9985	0.9985
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Trichomonas vaginalis	TKL family protein kinase	0.0083	0.6069	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0083	0.6069	0.6078
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0131	0.9985	0.9985
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0538	0.0539
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0083	0.6069	0.6069

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 8.54	Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hr	ChEMBL.	21498079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1783286

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1517253