Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0427 | 0.0602 |
Onchocerca volvulus | 0.0021 | 0.0427 | 0.5 | |
Brugia malayi | Doublecortin family protein | 0.0021 | 0.0427 | 0.1936 |
Brugia malayi | Hint module family protein | 0.0054 | 0.2207 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.0206 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2207 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.277 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1555 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0021 | 0.0427 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0427 | 0.0427 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.277 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1714 | 0.1714 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1714 | 0.7764 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.277 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2207 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0427 | 0.1936 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0017 | 0.0206 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.0427 | 0.5 | |
Trypanosoma brucei | cytochrome P450, putative | 0.0017 | 0.0206 | 0.5 |
Echinococcus granulosus | RUN | 0.0021 | 0.0427 | 0.0427 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.277 | 0.277 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0427 | 0.1936 |
Schistosoma mansoni | lipoxygenase | 0.0087 | 0.4011 | 0.5654 |
Schistosoma mansoni | lipoxygenase | 0.0124 | 0.6038 | 0.8512 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0206 | 0.0933 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.277 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.7094 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0017 | 0.0206 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1395 | 0.6321 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0427 | 0.1936 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.277 | 0.277 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0021 | 0.0427 | 0.0427 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.277 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.277 | 0.3904 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.277 | 1 |
Schistosoma mansoni | polycystin 1-related | 0.0021 | 0.0427 | 0.0602 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0427 | 0.0427 |
Brugia malayi | Hint module family protein | 0.0054 | 0.2207 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0427 | 0.0602 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.277 | 0.3904 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1714 | 0.1714 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0427 | 0.0602 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0124 | 0.6038 | 0.6038 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0427 | 0.0427 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1935 | 0.2728 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1935 | 0.2728 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0021 | 0.0427 | 0.5 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0427 | 0.1936 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1555 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0124 | 0.6038 | 0.6038 |
Schistosoma mansoni | loxhd1 | 0.0021 | 0.0427 | 0.0602 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0017 | 0.0206 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1714 | 0.7764 |
Echinococcus multilocularis | RUN | 0.0021 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | doublecortin family protein | 0.0021 | 0.0427 | 0.1936 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0021 | 0.0427 | 0.0427 |
Echinococcus multilocularis | hedgehog | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0206 | 0.0933 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.0206 | 0.0933 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 | Inhibition of human Erg by patch clamp assay | ChEMBL. | 21539377 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.