TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.196 | Formula: C15H16BrNO4
H donors: 2 H acceptors: 2 LogP: 0.88 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1cc(OCC2CCCNC2)c2c(c1)cc(o2)C(=O)O
InChi: 1S/C15H16BrNO4/c16-11-4-10-5-13(15(18)19)21-14(10)12(6-11)20-8-9-2-1-3-17-7-9/h4-6,9,17H,1-3,7-8H2,(H,18,19)
InChiKey: DBDYEQWRFONQEP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Pim-2 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein lipid droplet kinase (LDK)	Pim-2 proto-oncogene, serine/threonine kinase	311 aa	278 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G-protein coupled receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Trypanosoma cruzi	ubiquitin-activating enzyme E1, putative	0.0072	0.2041	1
Leishmania major	ubiquitin-activating enzyme e1, putative	0.0072	0.2041	1
Echinococcus multilocularis	neuropeptide s receptor	0.0086	0.2989	0.2776
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0086	0.2989	0.2776
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0104	0.4178	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0086	0.2989	0.2776
Echinococcus granulosus	ubiquitin modifier activating enzyme 6	0.0135	0.6186	0.607
Echinococcus multilocularis	ubiquitin modifier activating enzyme 6	0.0135	0.6186	0.607
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	G-protein coupled receptor	0.0086	0.2989	0.2776
Brugia malayi	Serotonin receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	clathrin coat associated protein ap-50	0.0083	0.2799	0.2637
Echinococcus multilocularis	neuropeptide receptor A26	0.0086	0.2989	0.2776
Brugia malayi	larval opioid receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0104	0.4178	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	neuropeptide receptor	0.0086	0.2989	0.2832
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0086	0.2989	0.2776
Loa Loa (eye worm)	melatonin receptor type 1A	0.0086	0.2989	0.2776
Schistosoma mansoni	neuropeptide F-like receptor	0.0086	0.2989	0.2832
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0086	0.2989	0.2776
Plasmodium falciparum	ubiquitin-activating enzyme E1	0.0135	0.6186	1
Echinococcus multilocularis	fmrfamide receptor	0.0086	0.2989	0.2776
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	amine GPCR	0.0086	0.2989	0.2832
Echinococcus multilocularis	ubiquitin modifier activating enzyme 1	0.0135	0.6186	0.607
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0086	0.2989	0.2776
Schistosoma mansoni	biogenic amine receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	adenoreceptor	0.0086	0.2989	0.2832
Trypanosoma cruzi	ubiquitin-activating enzyme E1, putative	0.0072	0.2041	1
Echinococcus granulosus	neuropeptide receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	biogenic amine receptor	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0086	0.2989	0.2832
Toxoplasma gondii	hypothetical protein	0.0054	0.0865	0.3205
Trypanosoma cruzi	NEDD8-activating enzyme E1 regulatory subunit, putative	0.0045	0.0295	0.1447
Schistosoma mansoni	serine/threonine protein kinase	0.0193	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0086	0.2989	0.2776
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	neuropeptides capa receptor	0.0086	0.2989	0.2776
Brugia malayi	Serotonin receptor	0.0086	0.2989	0.2776
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Brugia malayi	G-protein coupled receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0051	0.0662	0.2098
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0086	0.2989	0.2832
Loa Loa (eye worm)	ube1-prov protein	0.0135	0.6186	0.607
Brugia malayi	AKH receptor	0.0086	0.2989	0.2776
Echinococcus granulosus	7tm_1 domain containing protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Echinococcus granulosus	7TM GPCR rhodopsin	0.0086	0.2989	0.2776
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0045	0.0295	0.0411
Echinococcus granulosus	dro:myosuppressin receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	neuropeptide Y receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	g protein coupled receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	neuropeptide receptor	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	neuropeptide F-like receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	amine GPCR	0.0086	0.2989	0.2832
Entamoeba histolytica	ubiquitin-activating enzyme E1 1, putative	0.0104	0.4178	0.6591
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Echinococcus multilocularis	serotonin receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0193	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	hypothetical protein	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0045	0.0295	0.0411
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0086	0.2989	0.2776
Leishmania major	ubiquitin-activating enzyme e1, putative	0.0051	0.0662	0.2098
Echinococcus granulosus	fmrfamide receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	neuropeptide F receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	g protein coupled receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	neuropeptide receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0086	0.2989	0.2776
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	g protein coupled receptor	0.0086	0.2989	0.2776
Brugia malayi	RE15519p	0.0086	0.2989	0.2776
Echinococcus granulosus	neuropeptide receptor A26	0.0086	0.2989	0.2776
Schistosoma mansoni	neuropeptide receptor	0.0086	0.2989	0.2832
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0193	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	NEDD8 activating enzyme E1 catalytic subunit	0.0072	0.2072	0.1831
Echinococcus granulosus	g-protein coupled receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	neuropeptide receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	opsin-like receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	opsin-like receptor	0.0086	0.2989	0.2832
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.0054	0.0865	0.0587
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	neuropeptides capa receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	histamine h1 receptor	0.0086	0.2989	0.2832
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Echinococcus multilocularis	orexin receptor type 2	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	neuropeptide receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	G-protein coupled receptor	0.0086	0.2989	0.2776
Echinococcus granulosus	tm gpcr rhodopsin	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	amine GPCR	0.0086	0.2989	0.2832
Echinococcus granulosus	serotonin receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	somatostatin receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	g protein coupled receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	opsin-like receptor	0.0086	0.2989	0.2832
Echinococcus multilocularis	neuropeptides capa receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	NEDD8 activating enzyme E1 catalytic subunit	0.0072	0.2072	0.1831
Schistosoma mansoni	hypothetical protein	0.0086	0.2989	0.2832
Brugia malayi	GnHR receptor homolog	0.0086	0.2989	0.2776
Echinococcus multilocularis	fmrfamide receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	g-protein coupled receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0086	0.2989	0.2832
Brugia malayi	sulfakinin receptor protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0086	0.2989	0.2776
Echinococcus granulosus	sex peptide receptor	0.0086	0.2989	0.2776
Brugia malayi	ube1-prov protein	0.0135	0.6186	0.607
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	sex peptide receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0086	0.2989	0.2776
Brugia malayi	Melatonin receptor type 1A	0.0086	0.2989	0.2776
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0086	0.2989	0.2776
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0086	0.2989	0.2832
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0086	0.2989	0.2776
Brugia malayi	follicle stimulating hormone receptor	0.0086	0.2989	0.2776
Brugia malayi	Dopamine receptor protein 2	0.0086	0.2989	0.2776
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Trichomonas vaginalis	ubiquitin-activating enzyme E1 X, putative	0.0046	0.0387	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	ubiquitin modifier activating enzyme 1	0.0135	0.6186	0.607
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0086	0.2989	0.2776
Echinococcus granulosus	g protein coupled receptor	0.0086	0.2989	0.2776
Echinococcus granulosus	biogenic amine 5HT receptor	0.0086	0.2989	0.2776
Echinococcus granulosus	neuropeptide FF receptor 2	0.0086	0.2989	0.2776
Echinococcus granulosus	biogenic amine 5HT receptor	0.0086	0.2989	0.2776
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0072	0.2072	0.3017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0135	0.6186	1
Schistosoma mansoni	hypothetical protein	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Brugia malayi	G protein-coupled receptor F59B2.13	0.0086	0.2989	0.2776
Toxoplasma gondii	NEDD8-activating enzyme E1 catalytic subunit	0.0072	0.2072	1
Brugia malayi	Dopamine receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	biogenic amine receptor	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Brugia malayi	neuropeptide F receptor	0.0086	0.2989	0.2776
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0086	0.2989	0.2776
Schistosoma mansoni	amine GPCR	0.0086	0.2989	0.2832
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0054	0.0899	0.1901
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	serotonin receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0086	0.2989	0.2832
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0086	0.2989	0.2776
Echinococcus granulosus	g protein coupled receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0086	0.2989	0.2832
Brugia malayi	neuropeptide F receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Brugia malayi	putative neuropeptide receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0086	0.2989	0.2776
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	neuropeptide s receptor	0.0086	0.2989	0.2776
Brugia malayi	ORL1-like opioid receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	allatostatin A receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	G protein coupled receptor 139	0.0086	0.2989	0.2776
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0086	0.2989	0.2776
Echinococcus multilocularis	neuropeptide receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0193	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	myosin xvIII	0.0086	0.2989	0.2832
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Echinococcus multilocularis	neuropeptide Y receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0086	0.2989	0.2776
Schistosoma mansoni	app binding protein	0.0045	0.0295	0.0078
Brugia malayi	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0086	0.2989	0.2776
Giardia lamblia	Ubiquitin-conjugating enzyme E1	0.0072	0.2041	0.5
Plasmodium vivax	ubiquitin activating enzyme, putative	0.0054	0.0865	0.5
Schistosoma mansoni	clathrin coat associated protein ap-50	0.0083	0.2799	0.2637
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	neuropeptide Y receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	somatostatin receptor	0.0086	0.2989	0.2776
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0193	1	1
Brugia malayi	ThiF family protein	0.0054	0.0865	0.0587
Echinococcus granulosus	allatostatin A receptor	0.0086	0.2989	0.2776
Echinococcus granulosus	hypothetical protein	0.0086	0.2989	0.2776
Loa Loa (eye worm)	neuropeptide F receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	amine GPCR	0.0086	0.2989	0.2832
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0193	1	1
Brugia malayi	Dopamine receptor protein 1	0.0086	0.2989	0.2776
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0086	0.2989	0.2832
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0054	0.0865	0.066
Echinococcus granulosus	tm gpcr rhodopsin	0.0086	0.2989	0.2776
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0086	0.2989	0.2832
Schistosoma mansoni	growth hormone secretagogue receptor	0.0086	0.2989	0.2832
Echinococcus granulosus	orexin receptor type 2	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	neuropeptide f receptor 76f	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	G protein coupled receptor 139	0.0086	0.2989	0.2776
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.0054	0.0865	0.0587
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0086	0.2989	0.2776
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0086	0.2989	0.2832
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0072	0.2041	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Echinococcus granulosus	neuropeptide Y receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0086	0.2989	0.2832
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0086	0.2989	0.2832
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0193	1	1
Loa Loa (eye worm)	ectopic membrane ruffles in embryo protein 1	0.0072	0.2072	0.1831
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0086	0.2989	0.2776
Echinococcus multilocularis	dro:myosuppressin receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	ubiquitin-activating enzyme E1	0.0108	0.4453	0.4329
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0086	0.2989	0.2776
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0086	0.2989	0.2776
Echinococcus granulosus	neuropeptides capa receptor	0.0086	0.2989	0.2776
Brugia malayi	putative neuropeptide receptor NPR1	0.0086	0.2989	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0865	0.0587
Trichomonas vaginalis	ubiquitin-activating enzyme E1c, putative	0.0104	0.4178	1
Brugia malayi	Ectopic membrane ruffles in embryo protein 1	0.0072	0.2072	0.1831
Schistosoma mansoni	hypothetical protein	0.0086	0.2989	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2989	0.2776
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0086	0.2989	0.2776
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0086	0.2989	0.2776
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0086	0.2989	0.2776
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0086	0.2989	0.2776
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0086	0.2989	0.2776
Echinococcus granulosus	tm gpcr rhodopsin	0.0086	0.2989	0.2776
Loa Loa (eye worm)	TYRA-2 protein	0.0086	0.2989	0.2776
Brugia malayi	G protein-coupled receptor	0.0086	0.2989	0.2776
Schistosoma mansoni	ubiquitin-activating enzyme E1C	0.0072	0.2072	0.1895

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.071 uM	Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method	ChEMBL.	21507633
IC50 (binding)	= 0.33 uM	Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method	ChEMBL.	21507633

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1782520

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1520218