Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acetyltransferase, GNAT family protein | 0.0168 | 0.6029 | 0.6884 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.4464 | 0.3823 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.0206 | 0.0342 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0451 | 0.0747 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0206 | 0.0352 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0206 | 0.0235 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0451 | 0.0747 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.4464 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0206 | 0.0352 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0451 | 0.077 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0206 | 0.0342 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0206 | 0.0342 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0206 | 0.0235 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.1922 | 0.2195 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0206 | 0.0235 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0206 | 0.0342 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2505 | 0.4155 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0206 | 0.0342 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0206 | 0.0235 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0451 | 0.0747 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0206 | 0.0235 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0206 | 0.0342 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0206 | 0.0235 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0451 | 0.0747 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.2505 | 0.2861 |
Brugia malayi | Pre-SET motif family protein | 0.0242 | 0.8758 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0126 | 0.4464 | 0.5097 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.1038 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.4464 | 0.3823 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.2505 | 0.4155 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0206 | 0.0235 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0206 | 0.0342 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0206 | 0.0235 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.2505 | 0.428 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.1059 | 0.0366 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.4464 | 0.3823 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0206 | 0.0235 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0206 | 0.0342 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0045 | 0.1457 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0451 | 0.0515 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.1059 | 0.1756 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0126 | 0.4464 | 0.5097 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0451 | 0.0515 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.005 | 0.161 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.1011 | 0.1728 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0451 | 0.0515 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.1059 | 0.1209 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0206 | 0.0235 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0206 | 0.0342 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0045 | 0.1457 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0206 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0206 | 0.0235 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.2505 | 0.2861 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0206 | 0.0235 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2505 | 0.4155 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0206 | 0.0352 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | 6-phosphofructokinase | 0.0126 | 0.4464 | 0.5097 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0206 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1241 | 0.1417 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0206 | 0.0352 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0206 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1059 | 0.1209 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0206 | 0.0342 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.2505 | 0.2861 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0206 | 0.0342 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.4464 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.1059 | 0.1809 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.1059 | 0.1756 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0206 | 0.0235 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0206 | 0.0352 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2505 | 0.4155 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1241 | 0.1417 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0126 | 0.4464 | 0.7626 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0206 | 0.0235 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0045 | 0.1457 | 0.1224 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0126 | 0.4464 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0206 | 0.0342 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0126 | 0.4464 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0206 | 0.0342 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0206 | 0.0342 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0451 | 0.077 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2505 | 0.4155 |
Loa Loa (eye worm) | acetyltransferase | 0.0168 | 0.6029 | 0.6884 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.1059 | 0.1756 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0126 | 0.4464 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0206 | 0.0342 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.005 | 0.161 | 0.0639 |
Brugia malayi | RNA binding protein | 0.0074 | 0.2505 | 0.2861 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0126 | 0.4464 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.1922 | 0.2195 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0206 | 0.0235 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0451 | 0.0747 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0126 | 0.4464 | 0.3823 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0168 | 0.6029 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1241 | 0.2059 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0206 | 0.0342 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0206 | 0.0342 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2505 | 0.4155 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.005 | 0.161 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0206 | 0.0342 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.1059 | 0.1756 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0206 | 0.0235 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0206 | 0.0342 |
Brugia malayi | 6-phosphofructokinase | 0.0126 | 0.4464 | 0.5097 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.1059 | 0.1756 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0451 | 0.077 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0206 | 0.0352 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0206 | 0.0235 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.005 | 0.161 | 0.2751 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0206 | 0.0352 |
Brugia malayi | phosphofructokinase | 0.0126 | 0.4464 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.2505 | 0.2861 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0206 | 0.0235 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0168 | 0.6029 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.005 | 0.161 | 0.0639 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0206 | 0.0235 |
Trichomonas vaginalis | set domain proteins, putative | 0.0275 | 1 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0126 | 0.4464 | 0.5097 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.1059 | 0.0366 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0164 | 0.5854 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0206 | 0.0342 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.1059 | 0.1756 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0451 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0206 | 0.0235 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.1038 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0206 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0451 | 0.0515 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0126 | 0.4464 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0126 | 0.4464 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0206 | 0.0342 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0206 | 0.0352 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0206 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0206 | 0.0235 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.005 | 0.161 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.2505 | 0.2861 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0451 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1922 | 0.2195 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0126 | 0.4464 | 0.7404 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0206 | 0.0235 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.1922 | 0.2195 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0206 | 0.0235 |
Onchocerca volvulus | 0.0035 | 0.1059 | 0.0871 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.0126 | 0.4464 | 0.7404 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0126 | 0.4464 | 0.7404 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0206 | 0.0235 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0242 | 0.8758 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0126 | 0.4464 | 0.5 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0126 | 0.4464 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 4 % | Ability to inhibit the uptake of [3H]-dopamine (DA) 0.1 uM concentration at rat brain synaptosomes | ChEMBL. | 3039136 |
Inhibition (functional) | = 22 % | Ability to inhibit the uptake of [3H]- serotonin(5-HT) 0.1 microM concentration at rat brain synaptosomes | ChEMBL. | 3039136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.