Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 5 | 260 aa | 307 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0108 | 0.0728 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0108 | 0.0728 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0821 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0108 | 0.0728 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0108 | 0.0728 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0108 | 0.0728 | 0.0728 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0821 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0108 | 0.0728 | 1 |
Onchocerca volvulus | 0.0108 | 0.0728 | 0.5 | |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0108 | 0.0728 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0108 | 0.0728 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0713 | 0.8595 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0728 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0108 | 0.0728 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0728 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0108 | 0.0728 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0728 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0821 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0108 | 0.0728 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0821 | 1 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0713 | 0.8595 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0108 | 0.0728 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0108 | 0.0728 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0728 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0108 | 0.0728 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0728 | 1 |
Echinococcus multilocularis | 0.0108 | 0.0728 | 0.0728 | |
Schistosoma mansoni | amine oxidase | 0.0108 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0728 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0108 | 0.0728 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0108 | 0.0728 | 0.0728 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0108 | 0.0728 | 0.0846 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0108 | 0.0728 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0108 | 0.0728 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0108 | 0.0728 | 0.0728 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 418 nM | Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counter | ChEMBL. | 21353545 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.