Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | membrane metallo-endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | natriuretic peptide A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 0.5046 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.2861 | 0.4811 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.2626 | 0.4252 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0116 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.168 | 0.168 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.2861 | 0.4811 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.2861 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.1081 | 0.3419 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.5046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0347 | 0.0347 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0073 | 0.2626 | 0.2626 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.1081 | 0.0761 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3305 | 0.3305 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.1741 | 0.345 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.5046 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0116 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0116 | 0.023 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.1081 | 0.3419 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.089 | 0.2714 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.3305 | 0.3305 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3421 | 0.3421 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3305 | 0.3305 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.2861 | 0.567 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 0.2626 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.5046 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0116 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.089 | 0.089 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3421 | 0.3421 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3305 | 0.3305 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3305 | 0.3305 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.5046 | 0.5046 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 0.5046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3421 | 0.3421 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.003 | 0.0116 | 0.023 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.1741 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3421 | 0.3421 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0058 | 0.1741 | 0.345 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.5046 | 0.5046 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.2626 | 0.5 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0058 | 0.1741 | 0.345 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.2626 | 0.4252 |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.089 | 0.089 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0073 | 0.2626 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0077 | 0.2861 | 0.2861 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.5046 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0116 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0116 | 0.023 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.2861 | 0.4811 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3421 | 0.3421 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.2861 | 0.567 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.089 | 0.0563 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 0.5046 | 0.5046 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3421 | 0.3421 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.2626 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.168 | 0.1381 | |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0058 | 0.1741 | 0.345 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.3305 | 0.3305 |
Schistosoma mansoni | neprilysin | 0.003 | 0.0116 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.5046 | 0.5046 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.2626 | 0.2626 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.2861 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0199 | 1 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0114 | 0.5046 | 0.5046 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.089 | 0.2714 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.2626 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.5046 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0077 | 0.2861 | 0.2861 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.2861 | 0.4811 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.2626 | 0.5203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.