TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 546.569 | Formula: C33H26N2O6
H donors: 1 H acceptors: 5 LogP: 3.29 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: CCC1(O)CC(=O)OCc2c1cc1c3nc4ccc(cc4c(c3Cn1c2=O)C(=O)c1ccc2c(c1)cccc2)OC
InChi: 1S/C33H26N2O6/c1-3-33(39)15-28(36)41-17-24-25(33)14-27-30-23(16-35(27)32(24)38)29(22-13-21(40-2)10-11-26(22)34-30)31(37)20-9-8-18-6-4-5-7-19(18)12-20/h4-14,39H,3,15-17H2,1-2H3
InChiKey: AKWMFSVEKLMXHW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	DNA polymerase I	0.0057	0.0145	1
Brugia malayi	Protein kinase domain containing protein	0.0164	0.0522	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0101	0.03	0.1109
Entamoeba histolytica	SH2 domain containing protein	0.0063	0.0165	0.3137
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0164	0.0522	0.1544
Schistosoma mansoni	serine/threonine protein kinase	0.0101	0.03	0.5759
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Schistosoma mansoni	ephrin receptor	0.0101	0.03	0.5759
Entamoeba histolytica	ankyrin repeat protein	0.0101	0.03	0.5741
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0023	0.0025	0.0034
Entamoeba histolytica	serine/threonine kinase, putative	0.0101	0.03	0.5741
Brugia malayi	C-terminal src kinase protein 1	0.0101	0.03	0.0414
Loa Loa (eye worm)	SRC-1	0.0164	0.0522	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0063	0.0165	0.3166
Echinococcus multilocularis	tyrosine protein kinase	0.0101	0.03	0.0889
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0025	0.0073
Schistosoma mansoni	protein kinase	0.0101	0.0301	0.5772
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0063	0.0165	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	sex peptide receptor	0.0023	0.0025	0.0073
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0164	0.0522	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Schistosoma mansoni	tyrosine kinase	0.0164	0.0522	1
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Echinococcus granulosus	protein kinase C gamma type	0.0049	0.0118	0.035
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	ORL1-like opioid receptor	0.0023	0.0025	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0164	0.0522	0.0719
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0101	0.03	0.5741
Echinococcus multilocularis	insulin receptor	0.0101	0.03	0.0889
Schistosoma mansoni	tensin-related	0.0063	0.0165	0.3166
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	tyrosin kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	insulin receptor	0.0101	0.03	0.0889
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0023	0.0025	0.0475
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Echinococcus multilocularis	RNA directed DNA polymerase	0.0039	0.0083	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0101	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Toxoplasma gondii	RNA-directed DNA polymerase	0.0778	0.2691	1
Brugia malayi	Raf kinase	0.0101	0.03	0.0414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0101	0.03	0.5759
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0101	0.03	0.1109
Loa Loa (eye worm)	TK/INSR protein kinase	0.0101	0.03	0.5759
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.0025	0.0073
Echinococcus multilocularis	tensin	0.0063	0.0165	0.0489
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	cysteine surface protein, putative	0.0101	0.03	0.5741
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0063	0.0166	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0164	0.0522	0.1544
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus multilocularis	transfer RNA-Thr	0.0101	0.03	0.0889
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0164	0.0522	0.1544
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0025	0.0073
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.0025	0.0073
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Brugia malayi	AKH receptor	0.0023	0.0025	0.0034
Echinococcus granulosus	SHC transforming protein 3	0.0063	0.0165	0.0489
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Schistosoma mansoni	hypothetical protein	0.0101	0.03	0.5759
Schistosoma mansoni	serine/threonine protein kinase	0.0107	0.0322	0.6169
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	SH2 domain containing protein	0.0164	0.0522	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0083	0.1599
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.0025	0.0073
Onchocerca volvulus		0.0164	0.0522	0.0498
Brugia malayi	sulfakinin receptor protein	0.0023	0.0025	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	serine/threonine protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0002	0.0044
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0025	0.0475
Echinococcus multilocularis	tyrosine protein kinase csk	0.0101	0.03	0.0889
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0063	0.0165	0.3166
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0025	0.0475
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Schistosoma mansoni	protein kinase	0.0101	0.0301	0.5772
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0025	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Brugia malayi	hypothetical protein	0.0164	0.0522	0.0719
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Echinococcus granulosus	neuropeptide s receptor	0.0023	0.0025	0.0073
Echinococcus multilocularis	serotonin receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0023	0.0025	0.0475
Schistosoma mansoni	neuropeptide f receptor 76f	0.0023	0.0025	0.0475
Brugia malayi	neuropeptide F receptor	0.0023	0.0025	0.0034
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0101	0.03	0.5741
Schistosoma mansoni	hypothetical protein	0.0023	0.0025	0.0475
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0069	0.0187	0.3576
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0101	0.03	0.0889
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0101	0.03	0.0276
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Onchocerca volvulus		0.0164	0.0522	0.0498
Chlamydia trachomatis	DNA polymerase I	0.0057	0.0145	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0101	0.03	0.0414
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0101	0.03	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0063	0.0165	0.3166
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0101	0.03	0.0889
Schistosoma mansoni	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0101	0.03	0.0414
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Toxoplasma gondii	5'-3' exonuclease, N-terminal resolvase family domain-containing protein	0.002	0.0014	0.0044
Echinococcus granulosus	SH2 domain containing protein 7	0.0063	0.0165	0.0489
Schistosoma mansoni	adenoreceptor	0.0023	0.0025	0.0475
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0101	0.03	0.5759
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0023	0.0025	0.0475
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0101	0.03	0.0889
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Echinococcus granulosus	protein tyrosine kinase	0.0101	0.03	0.0889
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0101	0.03	0.0414
Entamoeba histolytica	hypothetical protein, conserved	0.0101	0.03	0.5741
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0778	0.2691	1
Echinococcus granulosus	expressed conserved protein	0.0063	0.0165	0.0489
Loa Loa (eye worm)	TK/FER protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.0025	0.0073
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.0025	0.0073
Schistosoma mansoni	growth factor receptor-bound protein	0.0063	0.0165	0.3166
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Brugia malayi	Guanylyl cyclase protein 23	0.0101	0.03	0.0414
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0101	0.03	0.0889
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0101	0.03	0.5759
Loa Loa (eye worm)	TK/ROR protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	TK/FAK protein kinase	0.0101	0.03	0.5759
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus granulosus	Protein kinase C brain isozyme	0.0055	0.0139	0.0413
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0101	0.03	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0101	0.03	0.0414
Schistosoma mansoni	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Protein kinase domain containing protein	0.0164	0.0522	0.0719
Brugia malayi	SH2 domain containing protein	0.0063	0.0165	0.0228
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0164	0.0522	0.1544
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0164	0.0522	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	RhoGAP domain containing protein	0.0069	0.0187	0.0257
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0025	0.0475
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Echinococcus granulosus	neuropeptide receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	TYRA-2 protein	0.0023	0.0025	0.0475
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0063	0.0165	0.0489
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0023	0.0025	0.0073
Schistosoma mansoni	amine GPCR	0.0023	0.0025	0.0475
Echinococcus multilocularis	signal transduction protein lnk realted	0.0063	0.0165	0.0489
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0101	0.03	0.5759
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.03	1
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0025	0.0073
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0063	0.0165	0.0489
Trypanosoma cruzi	protein kinase, putative	0.0101	0.03	0.1109
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Onchocerca volvulus	Tyrosine kinase homolog	0.0101	0.03	0.0276
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0023	0.0025	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	g-protein coupled receptor	0.0023	0.0025	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus granulosus	neuropeptide receptor A26	0.0023	0.0025	0.0073
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0164	0.0522	0.1544
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Schistosoma mansoni	protein kinase	0.0101	0.03	0.5759
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0101	0.03	0.0414
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0101	0.03	0.0889
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.0025	0.0073
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	SH2 domain-containing protein	0.0063	0.0165	0.3166
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Brugia malayi	follicle stimulating hormone receptor	0.0023	0.0025	0.0034
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0101	0.03	0.0889
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Echinococcus granulosus	tyrosine kinase	0.0164	0.0522	0.1544
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Plasmodium falciparum	tyrosine kinase-like protein	0.0101	0.03	0.1109
Echinococcus multilocularis	tyrosine protein kinase shark	0.0164	0.0522	0.1544
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0101	0.03	0.0414
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.03	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0025	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0023	0.0025	0.0073
Brugia malayi	Tensin	0.0063	0.0165	0.0228
Brugia malayi	Protein kinase domain containing protein	0.0164	0.0522	0.0719
Echinococcus multilocularis	SH2 motif	0.0063	0.0165	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0522	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Schistosoma mansoni	growth factor receptor-bound protein	0.0063	0.0165	0.3166
Brugia malayi	Furin-like cysteine rich region family protein	0.0101	0.03	0.0414
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0063	0.0165	0.0228
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0023	0.0025	0.0475
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Brugia malayi	putative neuropeptide receptor NPR1	0.0023	0.0025	0.0034
Echinococcus granulosus	tyrosine protein kinase csk	0.0101	0.03	0.0889
Mycobacterium leprae	PROBABLE DNA POLYMERASE I POLA	0.0057	0.0145	0.5
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	orexin receptor type 2	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Onchocerca volvulus		0.0101	0.03	0.0276
Onchocerca volvulus		0.0101	0.03	0.0276
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0025	0.0475
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Brugia malayi	Dopamine receptor protein 1	0.0023	0.0025	0.0034
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0023	0.0025	0.0034
Echinococcus granulosus	natriuretic peptide receptor 1	0.0101	0.03	0.0889
Schistosoma mansoni	myosin xvIII	0.0023	0.0025	0.0475
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	tyrosine protein kinase csk	0.0101	0.03	0.0889
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0023	0.0025	0.0073
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Schistosoma mansoni	ephrin receptor	0.0101	0.03	0.5759
Echinococcus multilocularis	SHC transforming protein 3	0.0063	0.0165	0.0489
Brugia malayi	hypothetical protein	0.0101	0.03	0.0414
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Echinococcus granulosus	sex peptide receptor	0.0023	0.0025	0.0073
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Loa Loa (eye worm)	TK protein kinase	0.0164	0.0522	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0101	0.0301	0.1111
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0023	0.0025	0.0073
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Onchocerca volvulus		0.0101	0.03	0.0276
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0101	0.03	0.0889
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.0165	0.0228
Plasmodium vivax	5'-3' exonuclease, N-terminal resolvase-like domain, putative	0.0041	0.0087	0.0315
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0164	0.0522	0.1544
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0101	0.03	0.0889
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Echinococcus granulosus	tyrosine protein kinase Blk	0.0164	0.0522	0.1544
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0023	0.0025	0.0475
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	tyrosine protein kinase csk	0.0101	0.03	0.0889
Loa Loa (eye worm)	TK/FER protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0164	0.0522	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Onchocerca volvulus		0.0063	0.0165	0.0141
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0101	0.03	0.0889
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	TK/Met protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0025	0.0073
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	protein kinase	0.0101	0.03	0.0889
Schistosoma mansoni	tyrosine kinase	0.0164	0.0522	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0101	0.03	0.5741
Schistosoma mansoni	amine GPCR	0.0023	0.0025	0.0475
Schistosoma mansoni	hypothetical protein	0.0063	0.0165	0.3166
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0101	0.03	0.0889
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0164	0.0522	0.1544
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0101	0.0301	0.1111
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Brugia malayi	SH2 domain containing protein	0.0063	0.0165	0.0228
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.0025	0.0073
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Echinococcus multilocularis	FL cytokine receptor	0.0101	0.03	0.0889
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Trypanosoma brucei	mitochondrial structure specific endonuclease I (SSE-1), putative	0.0041	0.0087	0.0315
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0164	0.0522	0.1544
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0025	0.0073
Schistosoma mansoni	tyrosine kinase	0.0164	0.0522	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.0025	0.0073
Echinococcus granulosus	tyrosine protein kinase Srms	0.0164	0.0522	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0101	0.03	0.0414
Entamoeba histolytica	protein kinase, putative	0.0063	0.0166	0.3149
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0063	0.0165	0.0141
Entamoeba histolytica	ankyrin repeat protein	0.0101	0.03	0.5741
Echinococcus multilocularis	neuropeptide receptor A26	0.0023	0.0025	0.0073
Entamoeba histolytica	serine/threonine kinase, putative	0.0101	0.03	0.5741
Echinococcus multilocularis	integrin linked protein kinase	0.0101	0.03	0.0889
Schistosoma mansoni	suppressor of cytokine signaling	0.0063	0.0165	0.3166
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Schistosoma mansoni	tyrosine kinase	0.0164	0.0522	1
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0023	0.0025	0.0073
Loa Loa (eye worm)	TK/FER protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0164	0.0522	0.1544
Trichomonas vaginalis	AGC family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	ephrin receptor 1 precursor	0.0101	0.03	0.0414
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0025	0.0475
Toxoplasma gondii	protein kinase domain-containing protein	0.0101	0.03	0.1109
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0101	0.03	0.5759
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Echinococcus granulosus	NCK adaptor protein	0.0063	0.0165	0.0489
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Brugia malayi	G-protein coupled receptor	0.0023	0.0025	0.0034
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0164	0.0522	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0101	0.03	0.0889
Echinococcus granulosus	hypothetical protein	0.0063	0.0165	0.0489
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0101	0.03	0.0889
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Plasmodium falciparum	tyrosine kinase-like protein	0.0101	0.03	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Echinococcus multilocularis		0.0063	0.0165	0.0489
Leishmania major	hypothetical protein, conserved	0.0101	0.03	0.1109
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0164	0.0522	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0063	0.0165	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0101	0.03	0.0414
Trypanosoma brucei	Pseudokinase, putative	0.0101	0.03	0.1109
Giardia lamblia	Telomerase catalytic subunit	0.0778	0.2691	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0101	0.03	0.0889
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0101	0.0301	0.0891
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Onchocerca volvulus		0.0101	0.03	0.0276
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Onchocerca volvulus		0.0101	0.03	0.0276
Schistosoma mansoni	growth hormone secretagogue receptor	0.0023	0.0025	0.0475
Echinococcus granulosus	orexin receptor type 2	0.0023	0.0025	0.0073
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0164	0.0522	0.1544
Brugia malayi	hypothetical protein	0.0101	0.03	0.0414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0164	0.0522	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0025	0.0475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0164	0.0522	0.1544
Schistosoma mansoni	protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0164	0.0522	0.1546
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0101	0.03	0.0889
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Entamoeba histolytica	tyrosin kinase, putative	0.0101	0.03	0.5741
Echinococcus granulosus	tyrosine protein kinase shark	0.0164	0.0522	0.1544
Echinococcus multilocularis	epidermal growth factor receptor	0.0101	0.03	0.0889
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Plasmodium falciparum	telomerase reverse transcriptase	0.0778	0.2691	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0101	0.03	0.0889
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Brugia malayi	Protein kinase domain containing protein	0.0164	0.0522	0.0719
Schistosoma mansoni	shc transforming protein	0.0063	0.0165	0.3166
Echinococcus granulosus	raf serine:threonine protein kinase	0.0107	0.0322	0.0953
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Schistosoma mansoni	tyrosine kinase	0.0164	0.0522	1
Echinococcus granulosus	activin receptor type	0.0101	0.0301	0.0891
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0164	0.0522	0.1544
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0025	0.0475
Trypanosoma cruzi	mitochondrial structure specific endonuclease I (SSE-1), putative	0.0041	0.0087	0.0315
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Schistosoma mansoni	protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0025	0.0073
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.0025	0.0073
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0023	0.0025	0.0475
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0023	0.0025	0.0073
Brugia malayi	SH2 domain containing protein	0.0063	0.0165	0.0228
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0025	0.0475
Echinococcus granulosus	c src tyrosine kinase	0.0164	0.0522	0.1544
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Onchocerca volvulus		0.0164	0.0522	0.0498
Echinococcus granulosus	signal transduction protein lnk realted	0.0063	0.0165	0.0489
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0101	0.03	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0101	0.03	0.0889
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0023	0.0025	0.0073
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0055	0.0139	0.0413
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0101	0.03	0.0889
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	SH2A	0.0063	0.0165	0.3166
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	activin receptor type	0.0101	0.0301	0.0891
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Brugia malayi	Tyrosine-protein kinase abl-1	0.0164	0.0522	0.0719
Trypanosoma cruzi	protein kinase, putative	0.0101	0.03	0.1109
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0101	0.03	0.0889
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0023	0.0025	0.0034
Schistosoma mansoni	protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0023	0.0025	0.0073
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0063	0.0165	0.0489
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0063	0.0165	0.0489
Echinococcus granulosus	G protein coupled receptor 139	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus multilocularis	G protein coupled receptor 139	0.0023	0.0025	0.0073
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0139	0.2673
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0101	0.03	0.0889
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Schistosoma mansoni	protein tyrosine kinase	0.0101	0.03	0.5759
Brugia malayi	G protein-coupled receptor F59B2.13	0.0023	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Loa Loa (eye worm)	TK/RYK protein kinase	0.0101	0.03	0.5759
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Onchocerca volvulus		0.0101	0.03	0.0276
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Echinococcus multilocularis	N chimaerin	0.0069	0.0187	0.0552
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0063	0.0165	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	RE15519p	0.0023	0.0025	0.0034
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0025	0.0073
Schistosoma mansoni	tensin	0.0063	0.0165	0.3166
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	TK/FER protein kinase	0.0101	0.03	0.5759
Schistosoma mansoni	adapter molecule crk	0.0063	0.0165	0.3166
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Echinococcus multilocularis	tyrosine kinase	0.0164	0.0522	0.1544
Brugia malayi	SH2 domain containing protein	0.0164	0.0522	0.0719
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0101	0.03	0.0889
Onchocerca volvulus		0.0063	0.0165	0.0141
Schistosoma mansoni	protein kinase	0.0101	0.03	0.5759
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0023	0.0025	0.0475
Brugia malayi	Serotonin receptor	0.0023	0.0025	0.0034
Echinococcus granulosus	tensin	0.0063	0.0165	0.0489
Brugia malayi	Melatonin receptor type 1A	0.0023	0.0025	0.0034
Schistosoma mansoni	serine/threonine RGC	0.0101	0.03	0.5759
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0973	0.3378	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0025	0.0475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus multilocularis	neuropeptide s receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Onchocerca volvulus		0.0063	0.0165	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Echinococcus multilocularis	NCK adaptor protein	0.0063	0.0165	0.0489
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0025	0.0475
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0063	0.0165	0.3166
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Schistosoma mansoni	signal transduction protein lnk-related	0.0063	0.0165	0.3166
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0063	0.0165	0.3166
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0069	0.0187	0.0552
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	7TM GPCR rhodopsin	0.0023	0.0025	0.0073
Echinococcus granulosus	activated cdc42 kinase 1	0.0101	0.03	0.0889
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0023	0.0025	0.0034
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Schistosoma mansoni	vav2	0.0069	0.0187	0.3576
Echinococcus multilocularis	somatostatin receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Echinococcus multilocularis	serine threonine protein kinase	0.0049	0.0118	0.035
Schistosoma mansoni	opsin-like receptor	0.0023	0.0025	0.0475
Trichomonas vaginalis	STE family protein kinase	0.0101	0.03	1
Echinococcus granulosus	fmrfamide receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	SH2 domain containing protein	0.0063	0.0165	0.0228
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	kinase suppressor of Ras 1	0.0101	0.03	0.0889
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0101	0.03	0.1109
Echinococcus multilocularis	SH2 motif	0.0063	0.0165	0.0489
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	serotonin receptor	0.0023	0.0025	0.0073
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0101	0.03	0.0889
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0101	0.03	0.0276
Loa Loa (eye worm)	TK/CSK protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0063	0.0165	0.0489
Schistosoma mansoni	tyrosine protein kinase	0.0101	0.03	0.5759
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0063	0.0165	0.0228
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0063	0.0165	0.0489
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0063	0.0165	0.0489
Loa Loa (eye worm)	TK/FER protein kinase	0.0101	0.03	0.5759
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0041	0.0088	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Toxoplasma gondii	STE kinase	0.0101	0.03	0.1109
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0023	0.0025	0.0034
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0025	0.0073
Trypanosoma brucei	protein kinase, putative	0.0101	0.0301	0.1111
Echinococcus multilocularis	epidermal growth factor receptor	0.0101	0.03	0.0889
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0101	0.03	0.1109
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0023	0.0025	0.0073
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0063	0.0165	0.0489
Schistosoma mansoni	protein kinase	0.0101	0.03	0.5759
Brugia malayi	SH2 domain containing protein	0.0063	0.0165	0.0228
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	TK/ACK protein kinase	0.0101	0.03	0.5759
Brugia malayi	larval opioid receptor	0.0023	0.0025	0.0034
Onchocerca volvulus		0.0101	0.03	0.0276
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus multilocularis	activated cdc42 kinase 1	0.0101	0.03	0.0889
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0101	0.03	0.0889
Echinococcus multilocularis	c src tyrosine kinase	0.0164	0.0522	0.1544
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0063	0.0165	0.0489
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.0025	0.0073
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	melatonin receptor type 1A	0.0023	0.0025	0.0475
Entamoeba histolytica	receptor protein kinase, putative	0.0101	0.03	0.5741
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0023	0.0025	0.0034
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0023	0.0025	0.0475
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0063	0.0165	0.0489
Echinococcus multilocularis	dro:myosuppressin receptor	0.0023	0.0025	0.0073
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0023	0.0025	0.0073
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0063	0.0165	0.3166
Schistosoma mansoni	opsin-like receptor	0.0023	0.0025	0.0475
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0101	0.03	0.5759
Wolbachia endosymbiont of Brugia malayi	DNA polymerase I	0.0057	0.0145	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.0025	0.0073
Entamoeba histolytica	serine/threonine kinase, putative	0.0101	0.03	0.5741
Brugia malayi	G-protein coupled receptor	0.0023	0.0025	0.0034
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0101	0.03	0.5759
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0139	0.2673
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	hypothetical protein	0.0023	0.0025	0.0073
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.03	1
Schistosoma mansoni	amine GPCR	0.0023	0.0025	0.0475
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Schistosoma mansoni	histamine h1 receptor	0.0023	0.0025	0.0475
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0063	0.0165	0.0489
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0101	0.03	0.0889
Echinococcus multilocularis	tensin	0.0063	0.0165	0.0489
Echinococcus granulosus	serotonin receptor	0.0023	0.0025	0.0073
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0164	0.0522	0.1544
Plasmodium vivax	protein kinase, putative	0.0101	0.03	0.1109
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Brugia malayi	SH2 domain containing protein	0.0063	0.0165	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.0025	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0025	0.0475
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Onchocerca volvulus		0.0063	0.0165	0.0141
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0101	0.03	0.0889
Schistosoma mansoni	amine GPCR	0.0023	0.0025	0.0475
Brugia malayi	Receptor family ligand binding region containing protein	0.0101	0.03	0.0414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Echinococcus granulosus	tyrosine kinase	0.0164	0.0522	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.0025	0.0073
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0025	0.0475
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0107	0.0322	0.0953
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0778	0.2691	1
Brugia malayi	Dopamine receptor	0.0023	0.0025	0.0034
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0101	0.03	0.1109
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0101	0.03	0.0889
Echinococcus multilocularis	protein tyrosine kinase	0.0101	0.03	0.0889
Schistosoma mansoni	tensin-related	0.0063	0.0165	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	SRC-1	0.0164	0.0522	0.0719
Echinococcus granulosus	allatostatin A receptor	0.0023	0.0025	0.0073
Brugia malayi	SH2 domain containing protein	0.0063	0.0165	0.0228
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0069	0.0187	0.3576
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Echinococcus multilocularis	SH2 domain containing protein 7	0.0063	0.0165	0.0489
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0023	0.0025	0.0475
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0101	0.03	0.5759
Onchocerca volvulus		0.0063	0.0165	0.0141
Brugia malayi	G protein-coupled receptor	0.0023	0.0025	0.0034
Trypanosoma cruzi	mitochondrial structure specific endonuclease I (SSE-1), putative	0.0041	0.0087	0.0315
Onchocerca volvulus		0.0164	0.0522	0.0498
Echinococcus granulosus	7tm_1 domain containing protein	0.0023	0.0025	0.0073
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.03	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0101	0.03	0.0414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.03	1
Echinococcus granulosus	epidermal growth factor receptor	0.0101	0.03	0.0889
Echinococcus granulosus	somatostatin receptor	0.0023	0.0025	0.0073
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Plasmodium falciparum	protein kinase, putative	0.0101	0.03	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Schistosoma mansoni	protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0101	0.03	0.0889
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Echinococcus granulosus	epidermal growth factor receptor	0.0101	0.03	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	putative neuropeptide receptor	0.0023	0.0025	0.0034
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.0025	0.0073
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0101	0.03	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0101	0.03	0.0414
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0063	0.0165	0.0489
Schistosoma mansoni	tyrosine kinase	0.0164	0.0522	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0105	0.2009
Schistosoma mansoni	nck2/grb4	0.0063	0.0165	0.3166
Brugia malayi	hypothetical protein	0.0063	0.0165	0.0228
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0025	0.0475
Echinococcus granulosus	RNA directed DNA polymerase	0.0039	0.0083	0.0247
Echinococcus multilocularis	SH2 motif	0.0063	0.0165	0.0489
Echinococcus granulosus	tyrosine protein kinase pr2	0.0101	0.03	0.0889
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0164	0.0522	0.1544
Schistosoma mansoni	opsin-like receptor	0.0023	0.0025	0.0475
Brugia malayi	Dopamine receptor protein 2	0.0023	0.0025	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	DNA polymerase I	0.0017	0.0002	0.0044
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0023	0.0025	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	DNA polymerase I family protein	0.0017	0.0002	0.0003
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.0165	0.0228
Entamoeba histolytica	tyrosin kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	Telomerase reverse transcriptase	0.207	0.7253	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0101	0.03	0.0889
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0063	0.0165	0.0489
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0101	0.03	0.0889
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0973	0.3378	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Brugia malayi	Variant SH3 domain containing protein	0.0064	0.017	0.0234
Echinococcus multilocularis	heat shock protein 70	0.0101	0.03	0.0889
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0063	0.0165	0.0489
Treponema pallidum	DNA polymerase I (polA)	0.0057	0.0145	0.5
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0025	0.0073
Echinococcus granulosus	activated cdc42 kinase 1	0.0101	0.03	0.0889
Schistosoma mansoni	amine GPCR	0.0023	0.0025	0.0475
Leishmania major	mitochondrial structure specific endonuclease I (SSE-1), putative	0.0041	0.0087	0.0315
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0063	0.0165	0.0489
Echinococcus granulosus	tyrosine protein kinase	0.0101	0.03	0.0889
Brugia malayi	integrin-linked kinase	0.0101	0.03	0.0414
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0025	0.0475
Echinococcus multilocularis	tyrosine protein kinase csk	0.0101	0.03	0.0889
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0101	0.03	0.5741
Echinococcus granulosus	g-protein coupled receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0101	0.03	0.5759
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0101	0.03	0.5741
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0063	0.0165	0.3166
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Onchocerca volvulus		0.0063	0.0165	0.0141
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0101	0.03	0.0889
Loa Loa (eye worm)	TK/EPH protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0025	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Mycobacterium tuberculosis	Probable DNA polymerase I PolA	0.0057	0.0145	1
Brugia malayi	Protein kinase domain containing protein	0.0101	0.03	0.0414
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0164	0.0522	0.1544
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0164	0.0522	0.1544
Leishmania major	protein kinase, putative	0.0101	0.03	0.1109
Entamoeba histolytica	receptor protein kinase, putative	0.0101	0.03	0.5741
Schistosoma mansoni	protein kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0063	0.0165	0.0489
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0023	0.0025	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Toxoplasma gondii	protein kinase	0.0101	0.03	0.1109
Schistosoma mansoni	protein kinase	0.0101	0.0301	0.5772
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.03	1
Brugia malayi	Serotonin receptor	0.0023	0.0025	0.0034
Brugia malayi	GnHR receptor homolog	0.0023	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0101	0.03	0.0889
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0101	0.03	0.5759
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0069	0.0187	0.3576
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0023	0.0025	0.0073
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0069	0.0187	0.0552
Echinococcus multilocularis	tyrosine kinase	0.0101	0.03	0.0889
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0101	0.0301	0.1111
Onchocerca volvulus		0.0164	0.0522	0.0498
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0101	0.03	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0164	0.0522	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.0025	0.0073
Onchocerca volvulus		0.0164	0.0522	0.0498
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.0301	0.5753
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.0025	0.0073
Brugia malayi	Protein kinase c protein 2	0.0047	0.011	0.0151
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0164	0.0522	0.1544
Echinococcus granulosus	SH2 motif	0.0063	0.0165	0.0489
Loa Loa (eye worm)	TK/FER protein kinase	0.0164	0.0522	1
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Echinococcus multilocularis	protein kinase	0.0101	0.03	0.0889
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0025	0.0475
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0039	0.0083	0.0247
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0023	0.0025	0.0475
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0164	0.0522	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0101	0.03	0.5759
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.0025	0.0073
Echinococcus granulosus	protein kinase	0.0101	0.03	0.0889
Loa Loa (eye worm)	TK/DDR protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	TK/FER protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0164	0.0522	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Loa Loa (eye worm)	SH2 domain-containing protein	0.0063	0.0165	0.3166
Trypanosoma brucei	telomerase reverse transcriptase	0.0778	0.2691	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0101	0.03	0.0889
Loa Loa (eye worm)	TK protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	tensin	0.0063	0.0165	0.3166
Brugia malayi	protein-tyrosine kinase	0.0164	0.0522	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0164	0.0522	0.1544
Schistosoma mansoni	GTPase activating protein	0.0063	0.0165	0.3166
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	tyrosine kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0064	0.017	0.3252
Echinococcus granulosus	dro:myosuppressin receptor	0.0023	0.0025	0.0073
Echinococcus granulosus	SH2 motif	0.0063	0.0165	0.0489
Schistosoma mansoni	serine/threonine protein kinase	0.0101	0.03	0.5759
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0063	0.0165	0.0141
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0025	0.0475
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0778	0.2691	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.03	0.5759
Loa Loa (eye worm)	SH2 domain-containing protein	0.0063	0.0165	0.3166
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0025	0.0475
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0101	0.03	1
Schistosoma mansoni	hypothetical protein	0.0063	0.0165	0.3166
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0101	0.03	0.0889
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0164	0.0522	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0063	0.0165	0.0489
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0025	0.0475
Trichomonas vaginalis	TK family protein kinase	0.0101	0.03	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0165	0.3166
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0101	0.03	0.5759
Brugia malayi	neuropeptide F receptor	0.0023	0.0025	0.0034
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0101	0.03	0.0889
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0101	0.03	1
Entamoeba histolytica	hypothetical protein	0.0101	0.03	0.5741
Brugia malayi	Sex muscle abnormal protein 5	0.0063	0.0165	0.0228
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0025	0.0475
Schistosoma mansoni	tensin	0.0063	0.0165	0.3166
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0023	0.0025	0.0073
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0101	0.03	0.5759
Plasmodium falciparum	protein kinase, putative	0.0101	0.0301	0.1111
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0025	0.0073
Leishmania major	telomerase reverse transcriptase, putative	0.0778	0.2691	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0063	0.0165	0.0228
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0101	0.03	0.0889
Entamoeba histolytica	tyrosine kinase, putative	0.0101	0.03	0.5741
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0187	0.0257
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0101	0.03	0.0889
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0025	0.0073
Plasmodium falciparum	5'-3' exonuclease, N-terminal resolvase-like domain, putative	0.0041	0.0087	0.0315
Echinococcus granulosus	tyrosine protein kinase HCK	0.0101	0.03	0.0889
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0101	0.03	0.0889
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	STAT protein	0.0063	0.0165	0.3166
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0101	0.03	0.5759
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.03	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0023	0.0025	0.0475
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0023	0.0025	0.0475
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0101	0.03	0.5759
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0023	0.0025	0.0073
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.0025	0.0073
Loa Loa (eye worm)	TK/ABL protein kinase	0.0164	0.0522	1
Echinococcus granulosus	integrin linked protein kinase	0.0101	0.03	0.0889
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0101	0.03	0.0889
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0025	0.0475
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0101	0.03	0.5741
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0164	0.0522	0.1544
Echinococcus granulosus	N chimaerin	0.0069	0.0187	0.0552
Onchocerca volvulus		0.0101	0.03	0.0276
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0101	0.0301	0.1111
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Echinococcus granulosus	tyrosine kinase	0.0101	0.03	0.0889
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0101	0.03	0.5759
Echinococcus granulosus	neuropeptide receptor	0.0023	0.0025	0.0073
Entamoeba histolytica	protein kinase, putative	0.0101	0.03	0.5741
Onchocerca volvulus		0.0101	0.03	0.0276
Echinococcus multilocularis	allatostatin A receptor	0.0023	0.0025	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0101	0.03	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0101	0.0301	0.0891
Leishmania major	protein kinase, putative	0.0101	0.0301	0.1111
Plasmodium falciparum	protein kinase, putative	0.0101	0.03	0.1109
Entamoeba histolytica	tyrosin kinase, putative	0.0101	0.03	0.5741
Loa Loa (eye worm)	serine/threonine protein kinase	0.0101	0.03	0.5759
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475
Entamoeba histolytica	protein kinase domain containing protein	0.0101	0.03	0.5741
Trichomonas vaginalis	protein kinase atn1, putative	0.0101	0.03	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0101	0.03	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0475

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 22.8 uM	Cytotoxicity against human HCT116 cells after 3 days by MTT assay	ChEMBL.	21463912
IC50 (functional)	> 100 uM	Cytotoxicity against human A549 cells after 3 days by MTT assay	ChEMBL.	21463912
IC50 (functional)	> 100 uM	Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay	ChEMBL.	21463912

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1782779

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1525457