Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.0073 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0019 | 0.4422 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.0073 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0019 | 0.3494 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.0447 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0019 | 0.3494 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0042 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.003 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.0073 | 0.1637 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.003 | 0.5 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0.000000000015768 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.0043 | 0.5 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0012 | 0.0019 | 0.042 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.0073 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0019 | 0.5 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.3135 | 1 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0019 | 0.4422 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.003 | 1 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.3135 | 1 | 0.5 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.003 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.0073 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0019 | 0.042 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0054 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.