Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.2029 | 0.1011 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.7097 | 1 |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.1459 | 0.1271 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0092 | 0.3038 | 0.3716 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3216 | 0.3117 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.1847 | 0.1871 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.3263 | 0.4064 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.1459 | 0.1271 |
Echinococcus multilocularis | 0.0056 | 0.1376 | 0.1142 | |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0026 | 0 | 0.5 |
Onchocerca volvulus | 0.0092 | 0.3038 | 0.5 | |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.1459 | 0.1271 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.1459 | 0.1968 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.3263 | 0.4064 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3038 | 0.3594 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.7097 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0882 | 0.019 |
Mycobacterium leprae | conserved hypothetical protein | 0.0026 | 0 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0758 | 0.097 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0092 | 0.3038 | 0.3716 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.3263 | 0.32 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0026 | 0 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.2624 | 0.3628 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.1459 | 0.11 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0243 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.1847 | 0.1871 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0092 | 0.3038 | 0.4218 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0026 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0092 | 0.3038 | 0.2802 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0243 | 1 | 0.5 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0979 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2407 | 0.2597 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.7097 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.7097 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.7097 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0243 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.3263 | 0.4064 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3216 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.3263 | 0.32 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.1459 | 0.1271 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3216 | 0.3117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 128 nM | Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A431 cell vesicles | ChEMBL. | 8568816 |
IC50 (binding) | = 128 nM | Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A431 cell vesicles | ChEMBL. | 8568816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.