Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0032 | 0.0538 | 0.0728 |
Echinococcus multilocularis | aldehyde reductase | 0.0023 | 0.0166 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1636 | 0.2709 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0042 | 0.095 | 0.0789 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0042 | 0.095 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0168 | 0.6041 | 0.9228 |
Leishmania major | prostaglandin f synthase, putative | 0.0032 | 0.0543 | 0.0114 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0127 | 0.4402 | 0.5966 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0042 | 0.095 | 0.0741 |
Echinococcus multilocularis | geminin | 0.0201 | 0.738 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.1971 | 0.2671 |
Echinococcus granulosus | geminin | 0.0201 | 0.738 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0032 | 0.0543 | 0.0736 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.097 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 0.0543 | 0.0899 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0179 | 0.6506 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0032 | 0.0543 | 0.0899 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0879 | 0.1455 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.1971 | 0.2671 |
Toxoplasma gondii | dihydroorotase | 0.0266 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Loa Loa (eye worm) | thymidylate synthase | 0.0127 | 0.4402 | 0.7288 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.1971 | 0.2671 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0032 | 0.0543 | 0.0899 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0179 | 0.6506 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.1971 | 0.2671 |
Echinococcus multilocularis | aldo keto reductase | 0.0032 | 0.0543 | 0.0736 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0042 | 0.095 | 0.1055 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0042 | 0.095 | 0.1573 |
Toxoplasma gondii | thioredoxin reductase | 0.0168 | 0.6041 | 0.5843 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0538 | 0.089 |
Onchocerca volvulus | 0.0032 | 0.0543 | 0.0015 | |
Echinococcus granulosus | hypothetical protein | 0.0032 | 0.0543 | 0.0736 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0052 | 0.1347 | 0.1461 |
Brugia malayi | Thioredoxin reductase | 0.0168 | 0.6041 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0538 | 0.0728 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0042 | 0.095 | 0.0789 |
Plasmodium falciparum | thioredoxin reductase | 0.0168 | 0.6041 | 0.5843 |
Brugia malayi | Dihydrofolate reductase | 0.0052 | 0.1347 | 0.2229 |
Trypanosoma cruzi | aldo-keto reductase | 0.0032 | 0.0543 | 0.0114 |
Onchocerca volvulus | 0.0032 | 0.0543 | 0.0015 | |
Schistosoma mansoni | aldo-keto reductase | 0.0032 | 0.0543 | 0.0736 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0032 | 0.0543 | 0.0114 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0052 | 0.1347 | 0.2082 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0168 | 0.6041 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 0.0543 | 0.0899 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0052 | 0.1347 | 0.1825 |
Echinococcus multilocularis | aldo keto reductase | 0.0032 | 0.0543 | 0.0736 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0042 | 0.095 | 0.05 |
Brugia malayi | glutathione reductase | 0.0168 | 0.6041 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.097 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.097 | 0.1315 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.1971 | 0.3263 |
Onchocerca volvulus | 0.0032 | 0.0543 | 0.0015 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.097 | 0.1315 |
Loa Loa (eye worm) | glutathione reductase | 0.0168 | 0.6041 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0168 | 0.6041 | 0.5843 |
Onchocerca volvulus | 0.0032 | 0.0543 | 0.0015 | |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Echinococcus granulosus | aldo keto reductase | 0.0032 | 0.0543 | 0.0736 |
Treponema pallidum | NADH oxidase | 0.0042 | 0.095 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.0538 | 0.0728 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0032 | 0.0543 | 0.0889 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.1971 | 0.2671 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0042 | 0.095 | 0.05 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0168 | 0.6041 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0538 | 0.0728 |
Plasmodium falciparum | glutathione reductase | 0.0042 | 0.095 | 0.05 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.1971 | 0.3263 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 0.0543 | 0.0899 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0879 | 0.1191 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0052 | 0.1347 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0475 | 0.0786 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0032 | 0.0543 | 0.0114 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Schistosoma mansoni | aldo-keto reductase | 0.0032 | 0.0543 | 0.0736 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0042 | 0.095 | 0.3529 |
Brugia malayi | hypothetical protein | 0.0061 | 0.1697 | 0.281 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0543 | 0.0899 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0042 | 0.095 | 0.1288 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.1636 | 0.2709 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Plasmodium vivax | glutathione reductase, putative | 0.0168 | 0.6041 | 0.5843 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0179 | 0.6506 | 0.6332 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0024 | 0.0234 | 0.0387 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1971 | 0.3263 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0127 | 0.4402 | 0.702 |
Onchocerca volvulus | 0.0032 | 0.0543 | 0.0015 | |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.1726 | 0.2339 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0538 | 0.089 |
Leishmania major | aldo-keto reductase-like protein | 0.0032 | 0.0543 | 0.0114 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0042 | 0.095 | 0.1288 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0169 | 0.6093 | 0.8256 |
Schistosoma mansoni | lamin | 0.0032 | 0.0538 | 0.0728 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0042 | 0.095 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.1971 | 0.3263 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0042 | 0.095 | 0.0741 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0179 | 0.6506 | 0.6332 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0042 | 0.095 | 0.0789 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0042 | 0.095 | 0.3529 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0514 | 0.0851 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0042 | 0.095 | 0.0789 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.097 | 0.1315 |
Brugia malayi | hypothetical protein | 0.0043 | 0.097 | 0.1606 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.1971 | 0.2671 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0032 | 0.0543 | 0.0899 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0042 | 0.095 | 0.05 |
Echinococcus granulosus | aldehyde reductase | 0.0023 | 0.0166 | 0.0226 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0061 | 0.1697 | 0.2099 |
Leishmania major | trypanothione reductase | 0.0168 | 0.6041 | 0.9228 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Plasmodium vivax | dihydroorotase, putative | 0.0266 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0042 | 0.095 | 0.1851 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0061 | 0.1697 | 0.2027 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0179 | 0.6506 | 0.6332 |
Onchocerca volvulus | 0.0127 | 0.4402 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.097 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.097 | 0.1315 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.097 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0042 | 0.095 | 0.0741 |
Schistosoma mansoni | lamin | 0.0032 | 0.0538 | 0.0728 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0538 | 0.0728 |
Echinococcus granulosus | dihydrofolate reductase | 0.0052 | 0.1347 | 0.1825 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0024 | 0.0234 | 0.0387 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0042 | 0.095 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 0.0543 | 0.0899 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0879 | 0.1455 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0042 | 0.095 | 0.0789 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0042 | 0.095 | 0.0789 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0032 | 0.0543 | 0.0114 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0168 | 0.6041 | 0.5843 |
Trypanosoma brucei | prostaglandin f synthase | 0.0032 | 0.0543 | 0.0114 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.1971 | 0.2671 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Toxoplasma gondii | aldose reductase, putative | 0.0032 | 0.0543 | 0.0072 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0042 | 0.095 | 0.05 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0538 | 0.089 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0168 | 0.6041 | 0.9228 |
Loa Loa (eye worm) | oxidoreductase | 0.0032 | 0.0543 | 0.0899 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.1636 | 0.2709 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.1697 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0538 | 0.089 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.738 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0127 | 0.4402 | 0.5966 |
Onchocerca volvulus | 0.0032 | 0.0543 | 0.0015 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0052 | 0.1347 | 0.2786 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0169 | 0.6093 | 0.8256 |
Mycobacterium ulcerans | thymidylate synthase | 0.0127 | 0.4402 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1971 | 0.3263 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.738 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0042 | 0.095 | 0.1288 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.095 | 0.0789 |
Brugia malayi | hypothetical protein | 0.002 | 0.0038 | 0.0063 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0032 | 0.0543 | 0.0899 |
Plasmodium falciparum | thioredoxin reductase | 0.0042 | 0.095 | 0.05 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Echinococcus granulosus | aldo keto reductase | 0.0032 | 0.0543 | 0.0736 |
Brugia malayi | thymidylate synthase | 0.0127 | 0.4402 | 0.7288 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0127 | 0.4402 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0052 | 0.1347 | 0.2229 |
Echinococcus granulosus | lamin | 0.0032 | 0.0538 | 0.0728 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0032 | 0.0543 | 0.0736 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0538 | 0.0728 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0032 | 0.0543 | 0.0114 |
Schistosoma mansoni | pol-related | 0.0032 | 0.0543 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0475 | 0.0786 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0042 | 0.095 | 0.05 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0042 | 0.095 | 0.05 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0052 | 0.1347 | 0.2229 |
Schistosoma mansoni | dihydrofolate reductase | 0.0052 | 0.1347 | 0.1825 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0042 | 0.095 | 0.0789 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0179 | 0.6506 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0127 | 0.4402 | 0.5966 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.1971 | 0.3263 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0032 | 0.0543 | 0.0736 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.1636 | 0.2709 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0042 | 0.095 | 0.1055 |
Echinococcus multilocularis | aldo keto reductase | 0.0032 | 0.0543 | 0.0736 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0042 | 0.095 | 0.1055 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0042 | 0.095 | 0.0741 |
Echinococcus granulosus | aldo keto reductase | 0.0032 | 0.0543 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0538 | 0.089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.