Detailed information for compound 1538144

Basic information

Technical information
  • TDR Targets ID: 1538144
  • Name: N-[[4-(morpholine-4-carbonyl)cyclohexyl]methy l]benzenesulfonamide
  • MW: 366.475 | Formula: C18H26N2O4S
  • H donors: 1 H acceptors: 3 LogP: 1.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)C1CCC(CC1)CNS(=O)(=O)c1ccccc1
  • InChi: 1S/C18H26N2O4S/c21-18(20-10-12-24-13-11-20)16-8-6-15(7-9-16)14-19-25(22,23)17-4-2-1-3-5-17/h1-5,15-16,19H,6-14H2
  • InChiKey: GHRJSKAXCABPES-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[4-(morpholino-oxomethyl)cyclohexyl]methyl]benzenesulfonamide
  • N-[(4-morpholin-4-ylcarbonylcyclohexyl)methyl]benzenesulfonamide
  • EU-0031568

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0118 0.1478 0.1478
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0242 0.1273
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0325 0.0474
Plasmodium falciparum glutathione reductase 0.0087 0.1047 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0264 0.0203
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.1115 0.1898
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0738 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0199 0.2583 0.892
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1223 0.1223
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0283 0.0283
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0095 0.1158 0.1158
Echinococcus granulosus dnaJ subfamily B 0.0419 0.5609 1
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.1115 0.1898
Loa Loa (eye worm) hypothetical protein 0.0032 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0068 0.0788 0.0788
Brugia malayi Importin beta-1 subunit 0.0028 0.0238 0.0238
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0328 0.4358 0.4358
Echinococcus multilocularis GPCR, family 2 0.0032 0.0283 0.04
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0264 0.0203
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0278 0.0389
Onchocerca volvulus 0.0243 0.3193 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0242 0.0325
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0872 0.1461
Trypanosoma brucei C-8 sterol isomerase, putative 0.0738 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0029 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0377 0.5037 0.5037
Loa Loa (eye worm) hypothetical protein 0.0738 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.0276 0.0386
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0264 0.0203
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0135 0.1274
Leishmania major GTP-binding protein, putative 0.0021 0.0135 0.0074
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0062 0.0062
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0238 0.0177
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0278 0.1526
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0242 0.1273
Plasmodium falciparum thioredoxin reductase 0.003 0.0264 0.2507
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0199 0.2583 0.892
Leishmania major importin beta-1 subunit, putative 0.0023 0.0164 0.0103
Loa Loa (eye worm) glutathione reductase 0.0087 0.1047 0.1047
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0062 0.0574
Brugia malayi Bromodomain containing protein 0.0029 0.0242 0.0242
Onchocerca volvulus 0.0029 0.0253 0.0037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0164 0.0095
Schistosoma mansoni ran 0.0021 0.0135 0.0132
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0283 0.04
Loa Loa (eye worm) hypothetical protein 0.0328 0.4358 0.4358
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0199 0.2583 0.892
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0264 0.0203
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0135 0.0074
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0221 0.2888 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0253 0.0253
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0283 0.0283
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0264 0.0203
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0221 0.2888 1
Brugia malayi glutathione reductase 0.0087 0.1047 0.1047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0348 0.0516
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0264 0.2507
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0264 0.0264
Leishmania major C-8 sterol isomerase-like protein 0.0738 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.1047 0.0992
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.2788 0.2788
Brugia malayi isocitrate dehydrogenase 0.0016 0.0062 0.0062
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1137 0.1939
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0264 0.5
Brugia malayi Pre-SET motif family protein 0.0214 0.2788 0.2788
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.1158 0.1977
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0715 0.1178
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0788 0.0788
Echinococcus granulosus thioredoxin glutathione reductase 0.0088 0.1054 0.1789
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0242 0.0242
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0264 0.0203
Mycobacterium tuberculosis Probable oxidoreductase 0.0221 0.2888 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0199 0.2583 0.892
Echinococcus multilocularis thioredoxin glutathione reductase 0.0088 0.1054 0.1789
Schistosoma mansoni transient receptor potential channel 0.0063 0.0715 0.1178
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0722 0.119
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0264 0.0422
Leishmania major trypanothione reductase 0.0087 0.1047 0.0992
Schistosoma mansoni hypothetical protein 0.0068 0.0788 0.131
Brugia malayi RNA, U transporter 1 0.008 0.0955 0.0955
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0116 0.0116
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.5609 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0264 0.2507
Plasmodium falciparum glutathione reductase 0.003 0.0264 0.2507
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0264 0.0203
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0242 0.0325
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0264 0.0203
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0264 0.0422
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0283 0.04
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1223 0.1223
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0264 0.0364
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0264 0.0203
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0396 0.0603
Schistosoma mansoni transient receptor potential channel 0.0063 0.0715 0.1178
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0135 0.0074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0264 0.5
Brugia malayi jmjC domain containing protein 0.0094 0.1137 0.1137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.063 0.4015
Echinococcus granulosus importin subunit beta 1 0.0028 0.0238 0.0317
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0164 0.0103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0283 0.04
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0278 0.0389
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0118 0.1478 0.1478
Schistosoma mansoni cpg binding protein 0.0031 0.0276 0.0386
Schistosoma mansoni hypothetical protein 0.0029 0.0242 0.0325
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0264 0.0203
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0264 0.5
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0715 0.1178
Loa Loa (eye worm) hypothetical protein 0.0049 0.0523 0.0523
Plasmodium falciparum importin beta, putative 0.0028 0.0238 0.2257
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0278 0.0389
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0264 0.1428
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0062 0.0574
Schistosoma mansoni hypothetical protein 0.0032 0.0283 0.04
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.1158 0.1977
Echinococcus multilocularis peregrin 0.0029 0.0242 0.0325
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0242 0.0325
Plasmodium vivax SET domain protein, putative 0.0031 0.0278 0.264
Brugia malayi Thioredoxin reductase 0.0087 0.1047 0.1047
Trichomonas vaginalis set domain proteins, putative 0.0243 0.3193 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0264 0.0203
Giardia lamblia PHD finger protein 15 0.0029 0.0242 0.8302
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0135 0.0132
Toxoplasma gondii hypothetical protein 0.0118 0.1478 1
Entamoeba histolytica hypothetical protein 0.0023 0.0164 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0278 0.0389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0264 0.0203
Plasmodium falciparum thioredoxin reductase 0.0087 0.1047 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0715 0.1178
Schistosoma mansoni cpg binding protein 0.0029 0.0253 0.0345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0264 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0278 0.0389
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0264 0.0364
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1223 0.1223
Brugia malayi jmjC domain containing protein 0.0036 0.0348 0.0348
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0062 0.0062
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0135 0.0074
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0715 0.1178
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.1047 1
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.1047 0.1047
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0153 0.0153
Schistosoma mansoni ran 0.0021 0.0135 0.0132
Schistosoma mansoni hypothetical protein 0.0032 0.0283 0.04
Schistosoma mansoni hypothetical protein 0.0419 0.5609 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0221 0.2888 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0283 0.0283
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0028 0.0238 0.0238
Toxoplasma gondii thioredoxin reductase 0.0087 0.1047 0.6959
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0264 0.2507
Plasmodium falciparum phd finger protein, putative 0.0029 0.0242 0.2298
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0283 0.04
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0264 0.0715
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0278 0.0389
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0348 0.0516
Schistosoma mansoni transient receptor potential channel 0.0095 0.1158 0.1977
Loa Loa (eye worm) hypothetical protein 0.006 0.0671 0.0671
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0164 0.0095
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0264 0.5
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0264 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.1158 0.1977
Echinococcus granulosus cpg binding protein 0.0031 0.0276 0.0386
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0264 0.1428
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0264 0.0203
Brugia malayi PHD-finger family protein 0.0029 0.0242 0.0242
Echinococcus granulosus jumonji domain containing protein 0.004 0.0396 0.0603
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0264 0.0203
Mycobacterium tuberculosis Probable reductase 0.0199 0.2583 0.892
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0336 0.0494
Plasmodium vivax glutathione reductase, putative 0.0087 0.1047 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0093 0.0056
Schistosoma mansoni importin beta-1 0.0028 0.0238 0.0317
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0153 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0278 0.0389
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0264 0.0203
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0264 0.5
Schistosoma mansoni hypothetical protein 0.0302 0.4003 0.7105
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0264 0.0364
Onchocerca volvulus 0.0031 0.0278 0.0121
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.4003 0.4003
Treponema pallidum NADH oxidase 0.003 0.0264 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0253 0.0346
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0238 0.0177
Schistosoma mansoni hypothetical protein 0.0032 0.0283 0.04
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1137 0.1939
Brugia malayi CXXC zinc finger family protein 0.0029 0.0253 0.0253
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0336 0.0494
Loa Loa (eye worm) hypothetical protein 0.0031 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0336
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0283 0.0283
Echinococcus granulosus snurportin 1 0.0302 0.4003 0.7105
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0242 0.2298
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0164 0.0095
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0348 0.0516
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.1047 0.3487
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0135 0.0517
Loa Loa (eye worm) hypothetical protein 0.01 0.1223 0.1223
Brugia malayi Pre-SET motif family protein 0.0031 0.0278 0.0278
Schistosoma mansoni hypothetical protein 0.0032 0.0283 0.04
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0264 0.5
Echinococcus multilocularis snurportin 1 0.0302 0.4003 0.7105
Echinococcus granulosus GPCR family 2 0.0032 0.0283 0.04
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0199 0.2583 0.892
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0661 0.0661
Trypanosoma brucei trypanothione reductase 0.0087 0.1047 0.0992
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0238 0.0317
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0135 0.0132
Echinococcus granulosus peregrin 0.0029 0.0242 0.0325
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0264 0.2507
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0238 0.1242
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0135 0.1274
Echinococcus multilocularis cpg binding protein 0.0031 0.0276 0.0386
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0264 0.0203
Plasmodium vivax importin-beta 2, putative 0.0028 0.0238 0.2257

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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