Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | renin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.58 | 1 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.098 | 0.1626 | 1 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1 | 0.0044 | 0 | 0.5 |
Treponema pallidum | licC protein (licC) | 0.098 | 0.1626 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0059 | 0.0025 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0059 | 0.0025 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0044 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.58 | 1 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.58 | 1 | 1 |
Brugia malayi | GnHR receptor homolog | 0.0044 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0044 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0059 | 0.0025 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0025 | 1 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0059 | 0.0025 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0059 | 0.0025 | 1 |
Brugia malayi | RE15519p | 0.0044 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0044 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0044 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0044 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.0225 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0044 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0059 | 0.0025 | 0.1123 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0044 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0044 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0059 | 0.0025 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0059 | 0.0025 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0044 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.0225 | 1 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0059 | 0.0025 | 1 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0.0025 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | sulfakinin receptor protein | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0044 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0044 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0044 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0059 | 0.0025 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 240 nM | The compound was tested for its inhibitory activity against human renal renin at pH 7 | ChEMBL. | No reference |
IC50 (binding) | = 240 nM | The compound was tested for its inhibitory activity against human renal renin at pH 7 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.