Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4565 | 0.405 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.5032 | 0.5032 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.1481 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.8091 | 0.791 |
Brugia malayi | hypothetical protein | 0.003 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.1481 | 0.0673 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.8686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.8686 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4565 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.8091 | 0.8091 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0866 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5032 | 0.456 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.1481 | 0.1481 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4565 | 0.405 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.8091 | 0.791 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.8686 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1481 | 0.0673 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4565 | 0.4565 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4565 | 0.4565 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4565 | 0.405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.8686 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.8686 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.8091 | 0.8091 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4565 | 0.4565 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0866 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4565 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.5032 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.