Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0001 | 0.0001 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2369 | 0.2369 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0029 | 0.0001 | 0.5 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0029 | 0.0001 | 0.0005 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.011 | 0.2369 | 0.2368 | |
Trypanosoma brucei | prolyl endopeptidase | 0.0029 | 0.0001 | 0.0005 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0029 | 0.0001 | 0.0005 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0029 | 0.0001 | 0.0001 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0029 | 0.0001 | 0.0005 |
Trypanosoma brucei | oligopeptidase b | 0.0029 | 0.0001 | 0.0005 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0001 | 0.0005 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.037 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0125 | 0.2792 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.037 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.011 | 0.2369 | 0.2369 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0.0001 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0.0001 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0125 | 0.2792 | 0.2792 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2369 | 0.2369 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0029 | 0.0001 | 0.5 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0029 | 0.0001 | 0.0005 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0125 | 0.2792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0001 | 0.0001 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0001 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.011 | 0.2369 | 0.2368 |
Brugia malayi | hypothetical protein | 0.0095 | 0.1931 | 0.1931 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0125 | 0.2792 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0029 | 0.0001 | 0.0001 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0029 | 0.0001 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0029 | 0.0001 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0125 | 0.2792 | 0.2791 |
Leishmania major | oligopeptidase b | 0.0029 | 0.0001 | 0.0005 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.011 | 0.2369 | 0.2369 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.011 | 0.2369 | 0.2368 |
Plasmodium falciparum | peptidase, putative | 0.0029 | 0.0001 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.011 | 0.2369 | 0.2369 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0029 | 0.0001 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0029 | 0.0001 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0125 | 0.2792 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0029 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2369 | 0.2369 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0029 | 0.0001 | 0.0005 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0029 | 0.0001 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0029 | 0.0001 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.011 | 0.2369 | 0.2368 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0125 | 0.2792 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.011 | 0.2369 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.011 | 0.2369 | 0.2368 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.037 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0029 | 0.0001 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0001 | 0.0001 |
Trypanosoma cruzi | oligopeptidase b | 0.0029 | 0.0001 | 0.0005 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0029 | 0.0001 | 0.5 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0029 | 0.0001 | 0.0005 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0125 | 0.2792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1931 | 0.1931 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0029 | 0.0001 | 0.0001 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0029 | 0.0001 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0125 | 0.2792 | 0.2791 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0029 | 0.0001 | 0.0005 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.011 | 0.2369 | 0.2369 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0029 | 0.0001 | 0.0005 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0029 | 0.0001 | 0.0001 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0125 | 0.2792 | 0.2791 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0001 | 0.0005 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0029 | 0.0001 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.037 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.