Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neurotensin receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Neurotensin receptor 1 | 424 aa | 399 aa | 22.1 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Neurotensin receptor 1 | 424 aa | 344 aa | 22.7 % |
Echinococcus granulosus | g protein coupled receptor | Neurotensin receptor 1 | 424 aa | 407 aa | 18.2 % |
Echinococcus multilocularis | g protein coupled receptor | Neurotensin receptor 1 | 424 aa | 407 aa | 17.7 % |
Onchocerca volvulus | Neurotensin receptor 1 | 424 aa | 420 aa | 23.6 % | |
Schistosoma mansoni | biogenic amine (5HT) receptor | Neurotensin receptor 1 | 424 aa | 417 aa | 24.0 % |
Onchocerca volvulus | Neurotensin receptor 1 | 424 aa | 457 aa | 21.4 % | |
Echinococcus multilocularis | neuropeptides capa receptor | Neurotensin receptor 1 | 424 aa | 420 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.013 | 0.222 | 0.6833 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.013 | 0.222 | 0.222 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0361 | 0.8259 | 0.8259 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.013 | 0.222 | 0.6833 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.013 | 0.222 | 0.7781 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0155 | 0.2853 | 0.2853 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0114 | 0.1784 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0361 | 0.8259 | 0.8259 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0428 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0078 | 0.0854 | 0.5 |
Onchocerca volvulus | 0.0428 | 1 | 1 | |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.013 | 0.222 | 0.6833 |
Brugia malayi | Peroxidasin | 0.0428 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0428 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0428 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0155 | 0.2853 | 0.2853 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1151 | 0.1151 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0428 | 1 | 1 |
Onchocerca volvulus | 0.0428 | 1 | 1 | |
Trypanosoma cruzi | prolyl endopeptidase | 0.0155 | 0.2853 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.013 | 0.222 | 0.222 |
Toxoplasma gondii | prolyl endopeptidase | 0.0155 | 0.2853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0931 | 0.0931 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0361 | 0.8259 | 0.8259 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0081 | 0.0931 | 0.0931 |
Schistosoma mansoni | peroxidasin | 0.0428 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0428 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.013 | 0.222 | 0.222 |
Giardia lamblia | High cysteine protein | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0428 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0428 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0089 | 0.1151 | 0.1151 |
Onchocerca volvulus | 0.0081 | 0.0931 | 0.0931 | |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0428 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0155 | 0.2853 | 0.2853 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0081 | 0.0931 | 0.0931 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0428 | 1 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0155 | 0.2853 | 0.2853 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.013 | 0.222 | 0.222 |
Brugia malayi | Animal haem peroxidase family protein | 0.0428 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0361 | 0.8259 | 0.8259 |
Brugia malayi | Cation transporter family protein | 0.0081 | 0.0931 | 0.0931 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0931 | 0.0931 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.013 | 0.222 | 0.6833 |
Schistosoma mansoni | peroxidasin | 0.0428 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0428 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.013 | 0.222 | 0.6833 |
Brugia malayi | Blistered cuticle protein 3 | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0428 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0361 | 0.8259 | 0.8259 |
Onchocerca volvulus | 0.0428 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0078 | 0.0854 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0155 | 0.2853 | 0.2853 |
Onchocerca volvulus | Peroxidasin homolog | 0.0428 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 0.0931 | 0.0931 | |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0361 | 0.8259 | 0.8259 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2853 | 0.2853 |
Onchocerca volvulus | 0.0081 | 0.0931 | 0.0931 | |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0155 | 0.2853 | 0.2853 |
Brugia malayi | Animal haem peroxidase family protein | 0.0428 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0155 | 0.2853 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0155 | 0.2853 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.89 uM | Tested for binding affinity against Neurotensin receptor | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.