Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glycogen phosphorylase | 0.0583 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0191 | 0.0191 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1009 | 0.1009 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0583 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0191 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0191 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0583 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0583 | 1 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0191 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.221 | 0.2058 |
Echinococcus granulosus | glycogen phosphorylase | 0.0583 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0252 | 0.4126 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0191 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0583 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1009 | 0.0833 |
Schistosoma mansoni | glycogen phosphorylase | 0.0252 | 0.4126 | 0.3467 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.221 | 0.221 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.221 | 0.2058 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0191 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1009 | 0.1009 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0583 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0191 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0583 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0583 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1009 | 0.1009 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1009 | 0.0833 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1009 | 0.0833 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0583 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0583 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0583 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0583 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0252 | 0.4126 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0583 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0191 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0583 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0583 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0191 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.