Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0878 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0878 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0271 | 0.0271 |
Echinococcus multilocularis | GPCR, family 2 | 0.015 | 0.1524 | 0.1524 |
Echinococcus granulosus | GPCR family 2 | 0.015 | 0.1524 | 0.1524 |
Schistosoma mansoni | tar DNA-binding protein | 0.0878 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.1524 | 0.1524 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0048 | 0.0341 | 0.0341 |
Schistosoma mansoni | Smad4 | 0.0042 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | Smad1 | 0.0042 | 0.0271 | 0.0271 |
Brugia malayi | hypothetical protein | 0.0105 | 0.1004 | 0.1004 |
Brugia malayi | Latrophilin receptor protein 2 | 0.015 | 0.1524 | 0.1524 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0042 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0474 | 0.5291 | 0.5291 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0105 | 0.1004 | 1 |
Brugia malayi | hypothetical protein | 0.0068 | 0.0571 | 0.0571 |
Leishmania major | hypothetical protein, conserved | 0.0105 | 0.1004 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1524 | 0.1524 |
Schistosoma mansoni | tar DNA-binding protein | 0.0878 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.1524 | 0.1524 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0042 | 0.0271 | 0.0271 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.015 | 0.1524 | 0.1524 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.5291 | 0.5291 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0042 | 0.0271 | 0.0271 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0878 | 1 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0042 | 0.0271 | 0.0271 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.015 | 0.1524 | 0.1524 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0105 | 0.1004 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0271 | 0.0271 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.1524 | 0.1524 |
Loa Loa (eye worm) | nuclear factor I | 0.0023 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0878 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.033 | 0.033 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0047 | 0.033 | 0.033 |
Echinococcus multilocularis | tar DNA binding protein | 0.0878 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0474 | 0.5291 | 0.5291 |
Brugia malayi | N-terminal motif family protein | 0.0196 | 0.2062 | 0.2062 |
Schistosoma mansoni | tar DNA-binding protein | 0.0878 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.2062 | 0.2062 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0105 | 0.1004 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0105 | 0.1004 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1513 | 0.1513 |
Brugia malayi | TAR-binding protein | 0.0878 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.0052 | 0.0052 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0105 | 0.1004 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0474 | 0.5291 | 0.5291 |
Echinococcus multilocularis | smad | 0.0042 | 0.0271 | 0.0271 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0105 | 0.1004 | 1 |
Brugia malayi | Smad1 | 0.0042 | 0.0271 | 0.0271 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0324 | 0.3548 | 0.3548 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0196 | 0.2062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0052 | 0.0052 |
Brugia malayi | isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Echinococcus granulosus | smad | 0.0042 | 0.0271 | 0.0271 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.015 | 0.1524 | 0.1524 |
Echinococcus multilocularis | Smad4 | 0.0042 | 0.0271 | 0.0271 |
Schistosoma mansoni | hypothetical protein | 0.0324 | 0.3548 | 0.3548 |
Brugia malayi | MH1 domain containing protein | 0.0023 | 0.0052 | 0.0052 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | RNA binding protein | 0.0878 | 1 | 1 |
Onchocerca volvulus | 0.0149 | 0.1513 | 0.7338 | |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0271 | 0.0271 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0619 | 0.6977 | 0.6977 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | TAR-binding protein | 0.0878 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Echinococcus granulosus | tar DNA binding protein | 0.0878 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.3548 | 0.3548 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0042 | 0.0271 | 0.0271 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0271 | 0.0271 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.015 | 0.1524 | 0.1524 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0042 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0619 | 0.6977 | 0.6977 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0105 | 0.1004 | 1 |
Schistosoma mansoni | smad | 0.0042 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0048 | 0.0341 | 0.0341 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0047 | 0.033 | 0.033 |
Schistosoma mansoni | smad1 5 8 and | 0.0042 | 0.0271 | 0.0271 |
Echinococcus granulosus | Smad4 | 0.0042 | 0.0271 | 0.0271 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.015 | 0.1524 | 0.1524 |
Brugia malayi | MH2 domain containing protein | 0.0619 | 0.6977 | 0.6977 |
Brugia malayi | hypothetical protein | 0.0149 | 0.1513 | 0.1513 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0042 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1004 | 0.1004 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0048 | 0.0341 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.1524 | 0.1524 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.015 | 0.1524 | 0.1524 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 2.9 nM kg-1 | Dose of the compound inhibiting the response of a dose of oxytocin to half of the response in rat | ChEMBL. | 10522694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.