Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1693 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1693 | 0.436 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0677 | 0.0713 |
Brugia malayi | manba-prov protein | 0.0077 | 0.2715 | 0.2858 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0239 | 1 | 1 |
Brugia malayi | Beta-glucuronidase precursor | 0.0221 | 0.9209 | 0.9693 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0677 | 0.0713 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1165 | 0.4799 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1693 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0677 | 0.0713 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0677 | 0.0713 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0161 | 0.6503 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.3007 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1165 | 0.2092 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0677 | 0.0713 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0228 | 0.95 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1165 | 0.4799 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1693 | 0.1782 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1693 | 0.1782 |
Schistosoma mansoni | beta-mannosidase | 0.0077 | 0.2715 | 0.8749 |
Loa Loa (eye worm) | beta-glucuronidase | 0.0221 | 0.9209 | 0.9693 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0651 | 0.0685 |
Onchocerca volvulus | 0.0032 | 0.0677 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.5712 | 0.6013 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0228 | 0.95 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1693 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1693 | 0.436 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1165 | 0.2092 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1693 | 0.436 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1165 | 0.1226 |
Onchocerca volvulus | 0.0032 | 0.0677 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.