Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | 0.0268 | 0.8241 | 0.8241 |
Mycobacterium ulcerans | glutaminase | 0.0316 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0316 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0266 | 0.8174 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0231 | 0.6923 | 0.6923 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0231 | 0.6923 | 1 |
Treponema pallidum | hypothetical protein | 0.0231 | 0.6923 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0231 | 0.6923 | 0.8469 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0 | 0.5 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0231 | 0.6923 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0268 | 0.8241 | 0.8241 |
Loa Loa (eye worm) | glutaminase | 0.0316 | 1 | 1 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0042 | 0 | 0.5 | |
Loa Loa (eye worm) | glutaminase 2 | 0.0316 | 1 | 1 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0231 | 0.6923 | 1 |
Schistosoma mansoni | glutaminase | 0.0316 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 430 uM | Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay | ChEMBL. | 21257308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.