Detailed information for compound 1561263

Basic information

Technical information
  • TDR Targets ID: 1561263
  • Name: 8-hydroxy-3,4-dihydro-1H-quinolin-2-one
  • MW: 163.173 | Formula: C9H9NO2
  • H donors: 2 H acceptors: 2 LogP: 0.71 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1)c(O)ccc2
  • InChi: 1S/C9H9NO2/c11-7-3-1-2-6-4-5-8(12)10-9(6)7/h1-3,11H,4-5H2,(H,10,12)
  • InChiKey: UDKMDIKMJWOSJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-hydroxy-3,4-dihydrocarbostyril
  • 52749-50-5
  • NSC108381

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuroligin 0.0075 0.061 0.113
Echinococcus granulosus acetylcholinesterase 0.0445 0.5399 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0221 0.041
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0303 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0075 0.061 0.5
Onchocerca volvulus 0.0075 0.061 1
Brugia malayi hypothetical protein 0.0075 0.061 0.113
Entamoeba histolytica hypothetical protein 0.0036 0.0107 0.5
Trichomonas vaginalis spcc417.12 protein, putative 0.0075 0.061 1
Brugia malayi Carboxylesterase family protein 0.0075 0.061 0.113
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0303 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0445 0.5399 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.061 0.113
Entamoeba histolytica hypothetical protein 0.0036 0.0107 0.5
Onchocerca volvulus 0.0075 0.061 1
Schistosoma mansoni hypothetical protein 0.0167 0.1802 0.3338
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0445 0.5399 1
Onchocerca volvulus 0.0075 0.061 1
Schistosoma mansoni acetylcholinesterase 0.0075 0.061 0.113
Echinococcus granulosus BC026374 protein S09 family 0.0075 0.061 0.113
Schistosoma mansoni hypothetical protein 0.0036 0.0107 0.0198
Loa Loa (eye worm) carboxylesterase 0.0445 0.5399 1
Schistosoma mansoni hypothetical protein 0.0167 0.1802 0.3338
Brugia malayi amidase 0.0103 0.097 0.1796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0221 0.041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0107 0.0107
Echinococcus granulosus tumor protein p63 0.0342 0.4055 0.7512
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0107 0.0198
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.061 0.113
Loa Loa (eye worm) hypothetical protein 0.0075 0.061 0.113
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0303 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0221 0.041
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.061 0.113
Echinococcus granulosus para nitrobenzyl esterase 0.0075 0.061 0.113
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0303 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.061 0.113
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0303 0.0561
Schistosoma mansoni gliotactin 0.0075 0.061 0.113
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0303 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0303 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0103 0.097 0.097
Loa Loa (eye worm) hypothetical protein 0.0445 0.5399 1
Echinococcus granulosus geminin 0.0167 0.1802 0.3338
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0075 0.061 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.003 0.5
Brugia malayi Carboxylesterase family protein 0.0445 0.5399 1
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0303 0.0303
Schistosoma mansoni fatty-acid amide hydrolase 0.0103 0.097 0.1796
Brugia malayi hypothetical protein 0.003 0.003 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0525
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0075 0.061 0.113
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0303 0.5
Onchocerca volvulus 0.0075 0.061 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0221 0.041
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0303 1
Echinococcus multilocularis neuroligin 0.0075 0.061 0.061
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0103 0.097 0.097
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0075 0.061 0.5
Brugia malayi Carboxylesterase family protein 0.0445 0.5399 1
Echinococcus granulosus carboxylesterase 5A 0.0445 0.5399 1
Trypanosoma brucei protein kinase, putative 0.0052 0.0303 1
Schistosoma mansoni hypothetical protein 0.0052 0.0313 0.058
Echinococcus multilocularis BC026374 protein (S09 family) 0.0075 0.061 0.061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0221 0.041
Loa Loa (eye worm) carboxylesterase 0.0075 0.061 0.113
Onchocerca volvulus 0.005 0.0283 0.4643
Brugia malayi Carboxylesterase family protein 0.0075 0.061 0.113
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0303 0.0561
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0303 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.061 0.113
Entamoeba histolytica hypothetical protein 0.0036 0.0107 0.5
Brugia malayi MAP kinase sur-1 0.0052 0.0303 0.0561
Schistosoma mansoni neuroligin 3 (S09 family) 0.0075 0.061 0.113
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0303 0.0561
Echinococcus multilocularis tumor protein p63 0.0342 0.4055 0.4055
Schistosoma mansoni amidase 0.0103 0.097 0.1796
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0075 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0103 0.097 0.1796
Echinococcus multilocularis acetylcholinesterase 0.0445 0.5399 0.5399
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0056
Brugia malayi hypothetical protein 0.0036 0.0107 0.0198
Echinococcus multilocularis acetylcholinesterase 0.0445 0.5399 0.5399
Mycobacterium ulcerans carboxylesterase, LipT 0.0075 0.061 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0221 0.041
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.061 0.113
Loa Loa (eye worm) hypothetical protein 0.0445 0.5399 1
Entamoeba histolytica hypothetical protein 0.0036 0.0107 0.5
Loa Loa (eye worm) carboxylesterase 0.0075 0.061 0.113
Loa Loa (eye worm) hypothetical protein 0.0075 0.061 0.113
Echinococcus granulosus fatty acid amide hydrolase 1 0.0103 0.097 0.1796
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0283 0.0525
Echinococcus granulosus acetylcholinesterase 0.0445 0.5399 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0107 0.0198
Echinococcus multilocularis para nitrobenzyl esterase 0.0075 0.061 0.061
Brugia malayi Carboxylesterase family protein 0.0075 0.061 0.113
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.003 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0303 0.0561
Loa Loa (eye worm) hypothetical protein 0.0075 0.061 0.113
Schistosoma mansoni BC026374 protein (S09 family) 0.0075 0.061 0.113
Loa Loa (eye worm) hypothetical protein 0.0075 0.061 0.113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0221 0.0221
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.003 0.5
Echinococcus granulosus fatty acid amide hydrolase 1 0.0103 0.097 0.1796
Brugia malayi Carboxylesterase family protein 0.0075 0.061 0.113
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0221 0.041
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0303 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0075 0.061 1
Onchocerca volvulus 0.0075 0.061 1
Echinococcus multilocularis geminin 0.0167 0.1802 0.1802
Echinococcus multilocularis carboxylesterase 5A 0.0445 0.5399 0.5399

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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