Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0072 | 0.1034 | 0.3563 |
Echinococcus granulosus | ectonucleotide | 0.0061 | 0.0824 | 0.7256 |
Echinococcus granulosus | DNA repair protein complementing XP G cells | 0.0035 | 0.0355 | 0.1123 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0043 | 0.0501 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0355 | 0.0434 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0035 | 0.0355 | 1 |
Echinococcus granulosus | Endonuclease G | 0.0043 | 0.0501 | 0.3033 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0035 | 0.0355 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0035 | 0.0355 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0155 | 0.2579 | 0.5521 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0061 | 0.0824 | 0.7256 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0035 | 0.0355 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0261 | 0.4538 | 1 |
Onchocerca volvulus | 0.0155 | 0.2579 | 1 | |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0035 | 0.0355 | 0.0736 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.4538 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0031 | 0.0269 | 0.0238 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0043 | 0.0501 | 1 |
Brugia malayi | hypothetical protein | 0.0261 | 0.4538 | 1 |
Schistosoma mansoni | endonuclease related | 0.0043 | 0.0501 | 0.1345 |
Brugia malayi | Flap endonuclease-1 | 0.0031 | 0.0269 | 0.0593 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0061 | 0.0824 | 0.7256 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.0269 | 0.3098 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0043 | 0.0501 | 0.1104 |
Echinococcus multilocularis | Endonuclease G | 0.0043 | 0.0501 | 0.3033 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.2579 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0043 | 0.0501 | 1 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0031 | 0.0269 | 0.3098 |
Trypanosoma cruzi | endonuclease G, putative | 0.0043 | 0.0501 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0824 | 0.1507 |
Leishmania major | endonuclease G, putative | 0.0043 | 0.0501 | 1 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0031 | 0.0269 | 0.548 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0072 | 0.1034 | 0.3563 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0072 | 0.1034 | 0.2278 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0072 | 0.1034 | 0.3563 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0061 | 0.0824 | 0.7256 |
Plasmodium falciparum | flap endonuclease 1 | 0.0031 | 0.0269 | 0.548 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0031 | 0.0269 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0043 | 0.0501 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.0269 | 0.3098 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0072 | 0.1034 | 0.3563 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0165 | 0.0363 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0155 | 0.2579 | 0.5684 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0035 | 0.0355 | 0.5654 |
Trypanosoma brucei | endonuclease G, putative | 0.0043 | 0.0501 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0043 | 0.0501 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1034 | 0.1986 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.0269 | 0.3098 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0043 | 0.0501 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0556 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1034 | 0.1986 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0035 | 0.0355 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1034 | 0.1986 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0072 | 0.1034 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0043 | 0.0501 | 1 |
Brugia malayi | XPG N-terminal domain containing protein | 0.003 | 0.0253 | 0.0559 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 170 nM | Binding affinity for Cholecystokinin type A receptor in guinea pig pancreas by using [125I]-BH-CCK-8 as radioligand | ChEMBL. | 1716682 |
IC50 (binding) | = 850 nM | Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]-BH-CCK-8 as radioligand | ChEMBL. | 1716682 |
Selectivity (functional) | = 5 | Selectivity ratio of IC50 measured in guinea pig cortex to that of IC50 for guinea pig pancreas | ChEMBL. | 1716682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.