Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | prostaglandin H2 D isomerase | 0.0066 | 0.0448 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.0066 | 0.0448 | 1 |
Schistosoma mansoni | Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) | 0.0066 | 0.0448 | 0.5 |
Trichomonas vaginalis | glutaminyl-tRNA synthetase, putative | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | GST class-mu | 0.0066 | 0.0448 | 0.5 |
Echinococcus multilocularis | glutathione S-transferase | 0.0066 | 0.0448 | 1 |
Plasmodium vivax | glutathione S-transferase, putative | 0.0066 | 0.0448 | 0.5 |
Schistosoma mansoni | glutathione-S-transferase | 0.0066 | 0.0448 | 0.5 |
Echinococcus multilocularis | glutathione S transferase | 0.0066 | 0.0448 | 1 |
Onchocerca volvulus | 0.0046 | 0 | 0.5 | |
Echinococcus granulosus | glutathione s transferase mu | 0.0066 | 0.0448 | 0.0448 |
Plasmodium falciparum | glutathione S-transferase | 0.0066 | 0.0448 | 0.5 |
Brugia malayi | glutathione transferase | 0.0253 | 0.4567 | 1 |
Echinococcus granulosus | glutathione S transferase | 0.0066 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4567 | 1 |
Echinococcus granulosus | prostaglandin H2 D isomerase | 0.0066 | 0.0448 | 0.0448 |
Echinococcus multilocularis | glutathione s transferase mu | 0.0066 | 0.0448 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.0066 | 0.0448 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 20 uM | Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay | ChEMBL. | 21489793 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.