Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0618 | 0.8895 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0684 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0421 | 0.5644 | 0.6346 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 0.8895 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0684 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0684 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0684 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0132 | 0.0841 | 0.0945 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0684 | 1 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0247 | 0.275 | 0.3937 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0132 | 0.0841 | 0.0945 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0247 | 0.275 | 0.3415 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0684 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0421 | 0.5644 | 0.7008 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0196 | 0.1909 | 0.2147 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0684 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0618 | 0.8895 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0132 | 0.0841 | 0.1204 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0567 | 0.8054 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0421 | 0.5644 | 0.6346 |
Loa Loa (eye worm) | glutamate receptor | 0.0502 | 0.6985 | 0.7853 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0841 | 0.0945 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0132 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0452 | 0.6144 | 0.8796 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0081 | 0 | 0.5 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0081 | 0 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0502 | 0.6985 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.