Detailed information for compound 1562677

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.371 | Formula: C19H17N5O2
  • H donors: 1 H acceptors: 4 LogP: 3.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(n1)n1c(nc(c1c(n2)C)C)c1cccc(c1)C(=O)N
  • InChi: 1S/C19H17N5O2/c1-10-16-11(2)22-18(13-6-4-5-12(9-13)17(20)25)24(16)19-14(21-10)7-8-15(23-19)26-3/h4-9H,1-3H3,(H2,20,25)
  • InChiKey: LPLOWECFLAFSLK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 10A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 2A, cGMP-stimulated Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References
Homo sapiens phosphodiesterase 9A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 8A Starlite/ChEMBL References
Bos taurus Phosphodiesterase 6A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4A, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 1B, calmodulin-dependent Starlite/ChEMBL References
Homo sapiens phosphodiesterase 7A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 11A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative Get druggable targets OG5_130344 All targets in OG5_130344
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase Get druggable targets OG5_130653 All targets in OG5_130653
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cGMP-dependent 3',5'-cyclic phosphodiesterase, putative Get druggable targets OG5_135549 All targets in OG5_135549
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135363 All targets in OG5_135363
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative Get druggable targets OG5_135549 All targets in OG5_135549
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135363 All targets in OG5_135363
Schistosoma japonicum ko:K06927 endoribonuclease, putative Get druggable targets OG5_130344 All targets in OG5_130344
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense 3, 5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum hypothetical protein Get druggable targets OG5_130344 All targets in OG5_130344
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_130344 All targets in OG5_130344
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase Get druggable targets OG5_135549 All targets in OG5_135549
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic Get druggable targets OG5_133100 All targets in OG5_133100
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative Get druggable targets OG5_130653 All targets in OG5_130653
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, putative Get druggable targets OG5_130344 All targets in OG5_130344
Leishmania infantum cAMP phosphodiesterase A Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum hypothetical protein Get druggable targets OG5_130653 All targets in OG5_130653
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_130653 All targets in OG5_130653
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase Get druggable targets OG5_130653 All targets in OG5_130653
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135549 All targets in OG5_135549
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Babesia bovis 3'5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130653 All targets in OG5_130653
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_135549 All targets in OG5_135549
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Trypanosoma brucei cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium parvum cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130653 All targets in OG5_130653
Plasmodium berghei 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic Get druggable targets OG5_135363 All targets in OG5_135363
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium hominis cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130653 All targets in OG5_130653
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_130344 All targets in OG5_130344
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) PDE1B protein Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cGMP-dependent 3',5'-cyclic phosphodiesterase, putative Get druggable targets OG5_135549 All targets in OG5_135549
Trypanosoma congolense 3', 5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic Get druggable targets OG5_133100 All targets in OG5_133100
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic Get druggable targets OG5_130344 All targets in OG5_130344
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Plasmodium yoelii asparagine-rich protein Get druggable targets OG5_130344 All targets in OG5_130344
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic Get druggable targets OG5_130344 All targets in OG5_130344
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130653 All targets in OG5_130653
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic Get druggable targets OG5_135363 All targets in OG5_135363
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Plasmodium yoelii cGMP phosphodiesterase A4, putative Get druggable targets OG5_130344 All targets in OG5_130344
Plasmodium knowlesi 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_130344 All targets in OG5_130344
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative Get druggable targets OG5_135363 All targets in OG5_135363
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum hypothetical protein Get druggable targets OG5_130653 All targets in OG5_130653
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 748 aa 23.7 %
Leishmania infantum cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 799 aa 25.3 %
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Phosphodiesterase 6A   859 aa 696 aa 22.0 %
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 788 aa 25.4 %
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 784 aa 23.2 %
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Phosphodiesterase 6A   859 aa 741 aa 23.8 %
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase phosphodiesterase 2A, cGMP-stimulated 934 aa 748 aa 27.1 %
Leishmania donovani cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 776 aa 24.7 %
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein phosphodiesterase 11A 489 aa 471 aa 34.4 %
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Phosphodiesterase 6A   859 aa 787 aa 23.8 %
Leishmania infantum cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 801 aa 24.7 %
Drosophila melanogaster Phosphodiesterase 6 Phosphodiesterase 6A   859 aa 778 aa 32.4 %
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Phosphodiesterase 6A   859 aa 775 aa 23.4 %
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 794 aa 23.3 %
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Phosphodiesterase 6A   859 aa 819 aa 29.3 %
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative phosphodiesterase 1B, calmodulin-dependent 536 aa 465 aa 28.2 %
Leishmania braziliensis cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 779 aa 24.4 %
Trypanosoma brucei cAMP-specific phosphodiesterase Phosphodiesterase 6A   859 aa 774 aa 25.3 %
Leishmania braziliensis cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 779 aa 24.4 %
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Phosphodiesterase 6A   859 aa 756 aa 22.9 %
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 818 aa 25.3 %
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Phosphodiesterase 6A   859 aa 745 aa 21.7 %
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Phosphodiesterase 6A   859 aa 747 aa 23.3 %
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 789 aa 25.6 %
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Phosphodiesterase 6A   859 aa 709 aa 23.8 %
Leishmania mexicana cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 782 aa 24.7 %
Trypanosoma brucei cAMP-specific phosphodiesterase phosphodiesterase 10A 789 aa 666 aa 30.2 %
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Phosphodiesterase 6A   859 aa 813 aa 30.6 %
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Phosphodiesterase 6A   859 aa 802 aa 22.1 %
Trypanosoma brucei cAMP-specific phosphodiesterase Phosphodiesterase 6A   859 aa 818 aa 25.3 %
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Phosphodiesterase 6A   859 aa 733 aa 21.7 %
Trichomonas vaginalis conserved hypothetical protein Phosphodiesterase 6A   859 aa 698 aa 18.9 %
Leishmania mexicana cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 775 aa 24.6 %
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Phosphodiesterase 6A   859 aa 771 aa 24.3 %
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Phosphodiesterase 6A   859 aa 816 aa 30.3 %
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Phosphodiesterase 6A   859 aa 781 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0158 0 0.5
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0331 0.3791 0.2668
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0309 0.3313 0.3229
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0247 0.1944 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0355 0.4319 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0158 0 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0214 0.1222 0.0743
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0227 0.1516 0.3376
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0791 0.1664
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0228 0.1532 0.1154
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0309 0.3313 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0483 0.7115 0.775
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0309 0.3313 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0309 0.3313 0.7623
Toxoplasma gondii hypothetical protein 0.0194 0.0791 0.1439
Trichomonas vaginalis conserved hypothetical protein 0.0355 0.4319 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.057 0.9007 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0228 0.1532 0.0353
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0483 0.7115 0.6594
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0214 0.1222 0.0743
Loa Loa (eye worm) hypothetical protein 0.05 0.7478 0.7127
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0309 0.3313 0.7623
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0309 0.3313 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0336 0.3906 0.2804
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0309 0.3313 0.7791
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0309 0.3313 0.7623
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0185 0.0597 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0336 0.3906 0.3934
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0214 0.1222 0.4638
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0214 0.1222 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0791 0.1664
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0247 0.1944 0.5
Loa Loa (eye worm) hypothetical protein 0.0615 1 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0483 0.7115 0.775
Loa Loa (eye worm) hypothetical protein 0.0256 0.2158 0.1067
Loa Loa (eye worm) hypothetical protein 0.0228 0.1532 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0791 0.1664
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0309 0.3313 0.7623
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0247 0.1944 0.2689
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0227 0.1516 0.3376
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0309 0.3313 0.7623
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0336 0.3906 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0214 0.1222 0.0743
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Loa Loa (eye worm) PDE1B protein 0.0336 0.3906 0.3058
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0309 0.3313 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0355 0.4319 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0309 0.3313 0.3229
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0198 0.0878 0.1034
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0309 0.3313 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.057 0.9007 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0355 0.4319 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.3791 0.2926
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0227 0.1516 0.3376
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0198 0.0878 0.1869
Loa Loa (eye worm) hypothetical protein 0.0368 0.4593 0.3841
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0214 0.1222 0.0743
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0247 0.1944 0.1601
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0336 0.3906 0.3934
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0247 0.1944 0.1601
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0331 0.3791 0.957
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0309 0.3313 0.7623
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0198 0.0878 0.1869
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0309 0.3313 0.7623

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.8 nM Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) = 37 nM Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) = 1870 nM Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) = 2080 nM Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) = 2810 nM Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) = 2930 nM Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) > 5000 nM Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) > 10000 nM Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) > 10000 nM Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) > 10000 nM Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay ChEMBL. 21988093
IC50 (binding) > 10000 nM Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assay ChEMBL. 21988093

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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