Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, shaker-related subfamily, member 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | voltage gated potassium channel | potassium voltage-gated channel, shaker-related subfamily, member 5 | 613 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gamma-secretase subunit aph-1 | 1.1218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.149 | 0.1251 | 0.1247 |
Loa Loa (eye worm) | hypothetical protein | 0.1977 | 0.1689 | 0.1685 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0787 | 0.0618 | 0.0618 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.4963 | 0.4375 | 1 |
Echinococcus granulosus | Nicastrin | 0.1977 | 0.1689 | 0.1685 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0125 | 0.0023 | 0.0019 |
Brugia malayi | hypothetical protein | 0.1977 | 0.1689 | 0.1685 |
Echinococcus multilocularis | Nicastrin | 0.1977 | 0.1689 | 0.1689 |
Echinococcus granulosus | presenilin enhancer 2 | 0.3807 | 0.3335 | 0.3332 |
Schistosoma mansoni | hypothetical protein | 0.1977 | 0.1689 | 0.1685 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 1.1218 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.4371 | 0.3842 | 0.8776 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.4963 | 0.4375 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0104 | 0.0004 | 0.0004 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 1.1218 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1738 | 0.1474 | 0.1471 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.4963 | 0.4375 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0787 | 0.0618 | 0.0615 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.1738 | 0.1474 | 0.1471 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.7049 | 0.6251 | 0.6249 |
Echinococcus multilocularis | nicalin | 0.0726 | 0.0564 | 0.0564 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.1145 | 0.0941 | 0.211 |
Toxoplasma gondii | hypothetical protein | 0.1738 | 0.1474 | 1 |
Brugia malayi | Presenilin spe-4 | 0.1738 | 0.1474 | 0.1471 |
Loa Loa (eye worm) | hypothetical protein | 0.5555 | 0.4907 | 0.4905 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0125 | 0.0023 | 0.5 |
Echinococcus granulosus | nicalin | 0.0726 | 0.0564 | 0.056 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0125 | 0.0023 | 0.0019 |
Trypanosoma brucei | Nicastrin, putative | 0.0726 | 0.0564 | 0.1244 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.4963 | 0.4375 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.4963 | 0.4375 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.4371 | 0.3842 | 0.8776 |
Brugia malayi | Cytochrome P450 family protein | 0.0125 | 0.0023 | 0.0019 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.4963 | 0.4375 | 1 |
Leishmania major | hypothetical protein, conserved | 0.1145 | 0.0941 | 0.211 |
Loa Loa (eye worm) | hypothetical protein | 0.2984 | 0.2595 | 0.2592 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0787 | 0.0618 | 0.0615 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.4963 | 0.4375 | 0.4373 |
Trypanosoma brucei | Aph-1 protein, putative | 0.4371 | 0.3842 | 0.8776 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0125 | 0.0023 | 0.0019 |
Brugia malayi | Cytochrome P450 family protein | 0.0125 | 0.0023 | 0.0019 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.257 | 0.2223 | 0.222 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.4963 | 0.4375 | 1 |
Trypanosoma cruzi | Nicastrin, putative | 0.0726 | 0.0564 | 0.1244 |
Brugia malayi | Presenilin spe-4 | 0.1738 | 0.1474 | 0.1471 |
Echinococcus multilocularis | Nicastrin | 0.1977 | 0.1689 | 0.1689 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.3807 | 0.3335 | 0.3335 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.3807 | 0.3335 | 0.3332 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 1.1218 | 1 | 1 |
Echinococcus granulosus | presenilin | 0.4963 | 0.4375 | 0.4373 |
Brugia malayi | Presenilin spe-4 | 0.1738 | 0.1474 | 0.1471 |
Brugia malayi | hypothetical protein | 0.1738 | 0.1474 | 0.1471 |
Loa Loa (eye worm) | presenilin spe-4 | 0.1738 | 0.1474 | 0.1471 |
Echinococcus multilocularis | presenilin | 0.4963 | 0.4375 | 0.4375 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.4963 | 0.4375 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.3807 | 0.3335 | 0.3332 |
Brugia malayi | Presenilin family protein | 0.4963 | 0.4375 | 0.4373 |
Brugia malayi | hypothetical protein | 0.1738 | 0.1474 | 0.1471 |
Brugia malayi | hypothetical protein | 0.1977 | 0.1689 | 0.1685 |
Trypanosoma cruzi | Nicastrin, putative | 0.0726 | 0.0564 | 0.1244 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 uM | Inhibitory effect against human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes | ChEMBL. | 15125940 |
IC50 (binding) | = 9 uM | Inhibitory effect against human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes | ChEMBL. | 15125940 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.