Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0465 | 0.0253 | 0.5 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0465 | 0.0253 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0465 | 0.0253 | 0.5 |
Onchocerca volvulus | 0.0465 | 0.0253 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0465 | 0.0253 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2536 | 0.5174 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2536 | 0.5174 | 1 |
Onchocerca volvulus | 0.0465 | 0.0253 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2536 | 0.5174 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2536 | 0.5174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4568 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0465 | 0.0253 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0465 | 0.0253 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0465 | 0.0253 | 0.5 |
Onchocerca volvulus | 0.0465 | 0.0253 | 0.5 | |
Onchocerca volvulus | 0.0465 | 0.0253 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2536 | 0.5174 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 2 uM | Inhibition of human recombinant MAO-B expressed in insect cells assessed as inhibition of kynuramine oxidation after 30 mins by fluorescence assay | ChEMBL. | 21923198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.