Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0084 | 0.0191 | 0.0235 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0261 | 0.0984 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | S-phase kinase-associated protein 1A | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0084 | 0.0191 | 0.0235 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0103 | 0.0276 | 0.0276 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 17 | 0.0084 | 0.0191 | 0.0651 |
Plasmodium vivax | potassium channel, putative | 0.0084 | 0.0191 | 0.1942 |
Plasmodium falciparum | potassium channel | 0.0084 | 0.0191 | 0.1942 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Onchocerca volvulus | 0.0084 | 0.0191 | 0.0465 | |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0261 | 0.0984 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 7 | 0.0084 | 0.0191 | 0.0651 |
Echinococcus multilocularis | TWiK family of potassium channels protein 7 | 0.0084 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Echinococcus granulosus | TWiK family of potassium channels protein 7 | 0.0084 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.1846 | 0.8123 | 1 |
Brugia malayi | Twik (KCNK-like) family of potasium channels, alpha subunit 40 | 0.0084 | 0.0191 | 0.0651 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.0084 | 0.0191 | 0.0651 |
Onchocerca volvulus | 0.0084 | 0.0191 | 0.0465 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Onchocerca volvulus | 0.0084 | 0.0191 | 0.0465 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0191 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Brugia malayi | Cache domain containing protein | 0.0456 | 0.1862 | 0.6351 |
Brugia malayi | Sugar transporter family protein | 0.0103 | 0.0276 | 0.094 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0045 | 0.0012 | 0.004 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0103 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0411 | 0.1663 | 0.1663 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Echinococcus multilocularis | serotonin receptor | 0.0411 | 0.1663 | 0.1663 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0276 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0411 | 0.1663 | 0.2047 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0084 | 0.0191 | 0.693 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0084 | 0.0191 | 0.693 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0103 | 0.0276 | 0.0276 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.2263 | 1 | 1 |
Echinococcus granulosus | twik family of potassium channels | 0.0084 | 0.0191 | 0.0191 |
Onchocerca volvulus | 0.0084 | 0.0191 | 0.0465 | |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog | 0.0084 | 0.0191 | 0.0651 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0103 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0084 | 0.0191 | 0.0465 | |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.1862 | 0.2293 |
Echinococcus granulosus | potassium channel subfamily K | 0.0084 | 0.0191 | 0.0191 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0084 | 0.0191 | 0.5 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0498 | 0.2052 | 0.2526 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0055 | 0.0058 | 0.0058 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0261 | 0.0984 | 1 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.1029 | 0.4445 | 0.4445 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0084 | 0.0191 | 0.0235 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0084 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.1663 | 0.2047 |
Echinococcus granulosus | twik family of potassium channels | 0.0084 | 0.0191 | 0.0191 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.0084 | 0.0191 | 0.0191 |
Plasmodium falciparum | hexose transporter | 0.0103 | 0.0276 | 0.2802 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 12 | 0.0084 | 0.0191 | 0.0651 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0084 | 0.0191 | 0.0235 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0084 | 0.0191 | 0.0235 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0084 | 0.0191 | 0.0235 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.1846 | 0.8123 | 0.8123 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0051 | 0.0039 | 0.0048 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1846 | 0.8123 | 1 |
Schistosoma mansoni | amine GPCR | 0.106 | 0.4584 | 0.5643 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0058 | 0.0071 |
Schistosoma mansoni | hypothetical protein | 0.0532 | 0.2204 | 0.2714 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.1029 | 0.4445 | 0.4445 |
Echinococcus multilocularis | potassium channel subfamily K | 0.0084 | 0.0191 | 0.0191 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 24 | 0.0084 | 0.0191 | 0.0651 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 5 | 0.0084 | 0.0191 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.0084 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0103 | 0.0276 | 0.0276 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0103 | 0.0276 | 0.0276 |
Schistosoma mansoni | hypothetical protein | 0.1846 | 0.8123 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0103 | 0.0276 | 0.0339 |
Echinococcus multilocularis | serotonin receptor | 0.0411 | 0.1663 | 0.1663 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.0084 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0324 | 0.0398 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.1846 | 0.8123 | 0.8123 |
Echinococcus multilocularis | twik family of potassium channels | 0.0084 | 0.0191 | 0.0191 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0261 | 0.0984 | 1 |
Treponema pallidum | 76K protein | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.0084 | 0.0191 | 0.0191 |
Onchocerca volvulus | 0.0084 | 0.0191 | 0.0465 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0084 | 0.0191 | 0.693 |
Toxoplasma gondii | ion channel protein | 0.0084 | 0.0191 | 0.1942 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.0084 | 0.0191 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.1663 | 0.2047 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.0084 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0779 | 0.332 | 0.4087 |
Plasmodium vivax | potassium channel, putative | 0.0084 | 0.0191 | 0.1942 |
Giardia lamblia | Telomerase catalytic subunit | 0.0261 | 0.0984 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Onchocerca volvulus | 0.0084 | 0.0191 | 0.0465 | |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0954 | 0.4105 | 1 |
Mycobacterium ulcerans | ion transport protein | 0.0084 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0084 | 0.0191 | 0.0235 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0276 | 0.0339 |
Echinococcus multilocularis | calcium activated potassium channel variant | 0.0084 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | glutamate receptor | 0.0045 | 0.0012 | 0.0014 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 39A | 0.0084 | 0.0191 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.3721 | 0.4581 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0084 | 0.0191 | 0.0235 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 13 | 0.0084 | 0.0191 | 0.0651 |
Plasmodium falciparum | potassium channel | 0.0084 | 0.0191 | 0.1942 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0987 | 0.4256 | 0.5239 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 21 | 0.0084 | 0.0191 | 0.0651 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0261 | 0.0984 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0055 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Schistosoma mansoni | glucose transport protein | 0.0103 | 0.0276 | 0.0339 |
Loa Loa (eye worm) | uncoordinated protein 58 | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | sugar transporter | 0.0103 | 0.0276 | 0.0339 |
Toxoplasma gondii | ion channel protein | 0.0084 | 0.0191 | 0.1942 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0084 | 0.0191 | 0.693 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 35 | 0.0084 | 0.0191 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog | 0.0084 | 0.0191 | 0.0651 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0103 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.0084 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0084 | 0.0191 | 0.0235 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0084 | 0.0191 | 0.693 |
Plasmodium vivax | hexose transporter | 0.0103 | 0.0276 | 0.2802 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1648 | 0.723 | 0.8901 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Onchocerca volvulus | 0.0084 | 0.0191 | 0.0465 | |
Schistosoma mansoni | serine-rich repeat protein | 0.0532 | 0.2204 | 0.2714 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0103 | 0.0276 | 0.2802 |
Echinococcus granulosus | General substrate transporter | 0.0089 | 0.021 | 0.021 |
Loa Loa (eye worm) | TWK-28 protein | 0.0084 | 0.0191 | 0.0235 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 45 | 0.0084 | 0.0191 | 0.0651 |
Loa Loa (eye worm) | TWK-7 protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0261 | 0.0984 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Echinococcus multilocularis | General substrate transporter | 0.0089 | 0.021 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0261 | 0.0984 | 1 |
Treponema pallidum | hypothetical protein | 0.0042 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0191 | 0.0651 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Brugia malayi | Telomerase reverse transcriptase | 0.0693 | 0.2932 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0103 | 0.0276 | 0.0276 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0084 | 0.0191 | 0.0235 |
Schistosoma mansoni | glucose transport protein | 0.0103 | 0.0276 | 0.0339 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.0084 | 0.0191 | 0.0191 |
Echinococcus multilocularis | twik family of potassium channels | 0.0084 | 0.0191 | 0.0191 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0084 | 0.0191 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 28 | 0.0084 | 0.0191 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 39B | 0.0084 | 0.0191 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0191 | 0.0235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 20 % | Growth inhibition of human MCF7 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 36 % | Growth inhibition of human HeLa cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 38 % | Growth inhibition of human PC3 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 41 % | Growth inhibition of human OVCAR5 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 50 % | Growth inhibition of human A549 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 54 % | Growth inhibition of human IMR32 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 54 % | Growth inhibition of human THP1 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.