Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0277 | 0.0393 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1749 | 0.6243 | 0.6231 |
Echinococcus multilocularis | serotonin transporter | 0.0149 | 0.0277 | 0.0245 |
Onchocerca volvulus | 0.0149 | 0.0277 | 0.0393 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0149 | 0.0277 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 0.2466 | 0.3918 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0104 | 0.0109 | 0.0077 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.144 | 0.5093 | 0.8148 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0075 | 0 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1749 | 0.6243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0277 | 0.0393 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1749 | 0.6243 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0149 | 0.0277 | 0.0393 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0149 | 0.0277 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.2756 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0149 | 0.0277 | 0.0393 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0075 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0075 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0149 | 0.0277 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0277 | 0.0393 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0669 | 0.2214 | 0.2189 |
Echinococcus granulosus | hypothetical protein | 0.0752 | 0.2526 | 0.2502 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0149 | 0.0277 | 0.0393 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0075 | 0 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.144 | 0.5093 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1749 | 0.6243 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1749 | 0.6243 | 0.6231 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1749 | 0.6243 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0149 | 0.0277 | 0.0245 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.144 | 0.5093 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0149 | 0.0277 | 0.0393 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0104 | 0.0109 | 0.0077 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0104 | 0.0109 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.144 | 0.5093 | 0.8148 |
Brugia malayi | Serotonin receptor | 0.053 | 0.1695 | 0.2677 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.144 | 0.5093 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.