Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0113 | 0.0243 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0113 | 0.0243 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0113 | 0.0113 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4653 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4653 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0113 | 0.0113 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0113 | 0.0243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4653 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3365 | 0.3365 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4653 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0113 | 0.0113 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.186 | 0.3997 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4653 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4653 | 0.4653 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4653 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0113 | 0.0243 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4653 | 0.4653 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.186 | 0.186 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0113 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3365 | 0.3365 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.186 | 0.186 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0113 | 0.0243 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3365 | 0.3365 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4653 | 0.4653 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4653 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0113 | 0.0243 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0113 | 0.0243 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0113 | 0.0243 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4653 | 0.4653 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0113 | 0.0243 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4653 | 0.4653 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4653 | 0.4653 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3365 | 0.3365 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.