Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | DNA helicase recq5 | 0.0009 | 0.0591 | 0.3494 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0018 | 0.1692 | 1 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0008 | 0.039 | 0.2303 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | adenoreceptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | opsin-like receptor | 0.0008 | 0.039 | 0.2303 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0009 | 0.0591 | 0.1051 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0008 | 0.039 | 0.2303 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0009 | 0.0591 | 0.1051 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | biogenic amine receptor | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | neuropeptide receptor | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Echinococcus granulosus | bloom syndrome protein | 0.0022 | 0.2307 | 1 |
Schistosoma mansoni | amine GPCR | 0.0008 | 0.039 | 0.2303 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0081 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0022 | 0.2307 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0008 | 0.039 | 0.5 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0591 | 0.1051 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | amine GPCR | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0591 | 0.1051 |
Echinococcus multilocularis | bloom syndrome protein | 0.0022 | 0.2307 | 1 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0008 | 0.039 | 0.2303 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0022 | 0.2307 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0591 | 0.4422 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0015 | 0.1361 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | opsin-like receptor | 0.0008 | 0.039 | 0.2303 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0008 | 0.039 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0008 | 0.039 | 0.2303 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0591 | 0.4422 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | amine GPCR | 0.0008 | 0.039 | 0.2303 |
Trypanosoma brucei | calpain-like protein, putative | 0.0081 | 1 | 1 |
Trypanosoma brucei | calpain, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1715 | 0.6916 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | opsin-like receptor | 0.0008 | 0.039 | 0.2303 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0591 | 0.1051 |
Schistosoma mansoni | biogenic amine receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0008 | 0.039 | 0.2303 |
Loa Loa (eye worm) | RecQ helicase | 0.0022 | 0.2307 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0009 | 0.0591 | 0.1051 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.039 | 0.2303 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0081 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0015 | 0.1337 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0022 | 0.2307 | 1 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | neuropeptide receptor | 0.0008 | 0.039 | 0.2303 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0009 | 0.0591 | 0.1051 |
Trypanosoma brucei | variant surface glycoprotein (VSG), putative | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | neuropeptide receptor | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0009 | 0.0591 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0008 | 0.039 | 0.2303 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0009 | 0.0591 | 0.1051 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.1952 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0009 | 0.0591 | 0.3494 |
Schistosoma mansoni | biogenic amine receptor | 0.0008 | 0.039 | 0.2303 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0008 | 0.039 | 0.2303 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0008 | 0.039 | 0.2303 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0081 | 1 | 1 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0.039 | 0.5 | |
Schistosoma mansoni | myosin xvIII | 0.0008 | 0.039 | 0.2303 |
Trypanosoma brucei | hypothetical protein | 0.0081 | 1 | 1 |
Schistosoma mansoni | amine GPCR | 0.0008 | 0.039 | 0.2303 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | histamine h1 receptor | 0.0008 | 0.039 | 0.2303 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0008 | 0.039 | 0.2303 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0081 | 1 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0012 | 0.0946 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Inhibition of IR expression in Balb/C mouse kidney assessed as upregulation of IR-A transcript at 1.5 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (functional) | Inhibition of IR expression in Balb/C mouse liver assessed as upregulation of IR-A transcript at 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (functional) | Inhibition of IR expression in Balb/C mouse adipose tissue assessed as reduction in IR-B transcript at 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (ADMET) | Acute toxicity in Balb/C mouse assessed as reduction in body weight at 1.5 to 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose | ChEMBL. | 20420385 | |
Activity (functional) | Inhibition of IR expression in Balb/C mouse liver assessed as upregulation of IR-A transcript at 1.5 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (functional) | Inhibition of IR expression in Balb/C mouse kidney assessed as reduction in IR-B transcript at 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (functional) | Inhibition of IR expression in Balb/C mouse kidney assessed as reduction in IR-B transcript at 1.5 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (ADMET) | Acute toxicity in Balb/C mouse assessed as change in plasma chemistry at 1.5 to 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose | ChEMBL. | 20420385 | |
Activity (functional) | Inhibition of IR expression in Balb/C mouse liver assessed as reduction in IR-B transcript at 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (functional) | Inhibition of IR expression in Balb/C mouse kidney assessed as upregulation of IR-A transcript at 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (ADMET) | Acute toxicity in Balb/C mouse assessed as change in spleen weight at 1.5 to 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose | ChEMBL. | 20420385 | |
Activity (functional) | Inhibition of IR expression in Balb/C mouse adipose tissue assessed as upregulation of IR-A transcript at 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose by Western blot analysis | ChEMBL. | 20420385 | |
Activity (ADMET) | Acute toxicity in Balb/C mouse assessed as change in liver weight at 1.5 to 6.0 umol/kg, ip administered thrice a week for 2 weeks measured 48 hrs after last dose | ChEMBL. | 20420385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.