Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase alpha | Starlite/ChEMBL | References |
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.862 | 0.8595 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0239 | 0.4183 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0239 | 0.4183 | 1 |
Brugia malayi | Peptidase family M28 containing protein | 0.0239 | 0.4183 | 0.4066 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0203 | 0.338 | 0.7985 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0203 | 0.338 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0203 | 0.338 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0196 | 0.3222 | 0.3086 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0077 | 0.0588 | 0.1741 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0239 | 0.4183 | 1 |
Chlamydia trachomatis | biotin carboxylase | 0.007 | 0.043 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0077 | 0.0588 | 0.5 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0203 | 0.338 | 0.7985 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0147 | 0.2134 | 0.5 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.05 | 0.9996 | 1 |
Schistosoma mansoni | pyruvate carboxylase | 0.0077 | 0.0588 | 0.0981 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0077 | 0.0588 | 0.0981 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0077 | 0.0588 | 0.0981 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0239 | 0.4183 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0077 | 0.0588 | 0.5 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0077 | 0.0588 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0077 | 0.0588 | 0.5 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0126 | 0.1662 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0077 | 0.0588 | 0.0981 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0203 | 0.338 | 0.7985 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0077 | 0.0588 | 0.5 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0147 | 0.2134 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0077 | 0.0588 | 0.1741 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0196 | 0.3222 | 0.3085 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.4183 | 0.4067 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0077 | 0.0588 | 0.5 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0077 | 0.0588 | 0.5 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0203 | 0.338 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0077 | 0.0588 | 0.0981 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0203 | 0.338 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0077 | 0.0588 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.