Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0679 | 0.0356 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.0417 | 0.0159 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.0417 | 0.0085 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0298 | 0.1221 | 0.0917 |
Onchocerca volvulus | 0.0208 | 0.0679 | 1 | |
Onchocerca volvulus | 0.0208 | 0.0679 | 1 | |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.0417 | 0.0159 |
Brugia malayi | Choline O-acetyltransferase | 0.0208 | 0.0679 | 0.0356 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0298 | 0.1221 | 0.1715 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0208 | 0.0679 | 0.0356 |
Schistosoma mansoni | choline o-acyltransferase | 0.0208 | 0.0679 | 1 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0298 | 0.1221 | 0.1123 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0298 | 0.1221 | 0.0917 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1011 | 0.5504 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1011 | 0.5504 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1011 | 0.5504 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0298 | 0.1221 | 0.1715 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0208 | 0.0679 | 0.0666 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0298 | 0.1221 | 1 |
Onchocerca volvulus | 0.0208 | 0.0679 | 1 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.0417 | 0.0085 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1011 | 0.5504 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0298 | 0.1221 | 0.1123 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0208 | 0.0679 | 0.0356 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0208 | 0.0679 | 0.0356 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.0417 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.1759 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1011 | 0.5504 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0208 | 0.0679 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0208 | 0.0679 | 0.0356 |
Onchocerca volvulus | 0.0208 | 0.0679 | 1 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0208 | 0.0679 | 0.0666 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 6 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.