Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | memapsin-2 (A01 family) | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Schistosoma japonicum | ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Choline O-acetyltransferase | 0.0528 | 0.1268 | 0.1268 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0997 | 0.2472 | 1 |
Onchocerca volvulus | 0.0528 | 0.1268 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2238 | 0.5656 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0528 | 0.1268 | 0.1268 |
Brugia malayi | Choline O-acetyltransferase | 0.0528 | 0.1268 | 0.1268 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0997 | 0.2472 | 0.2472 |
Onchocerca volvulus | 0.0528 | 0.1268 | 1 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0528 | 0.1268 | 1 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0997 | 0.2472 | 0.2745 |
Loa Loa (eye worm) | hypothetical protein | 0.393 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0528 | 0.1268 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0528 | 0.1268 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.1268 | 0.1268 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2238 | 0.5656 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0528 | 0.1268 | 0.2242 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2238 | 0.5656 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2238 | 0.5656 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0997 | 0.2472 | 0.2472 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2238 | 0.5656 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0528 | 0.1268 | 0.1268 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0997 | 0.2472 | 0.4371 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0997 | 0.2472 | 0.2745 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0521 | 0.1249 | 0.9853 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0997 | 0.2472 | 0.4371 |
Onchocerca volvulus | 0.0528 | 0.1268 | 1 | |
Echinococcus multilocularis | choline O acetyltransferase | 0.0528 | 0.1268 | 0.2242 |
Onchocerca volvulus | 0.0528 | 0.1268 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.