Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0465 | 0.0253 | 0.5 | |
Onchocerca volvulus | 0.0465 | 0.0253 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2536 | 0.5174 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0465 | 0.0253 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0465 | 0.0253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4568 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0465 | 0.0253 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2536 | 0.5174 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2536 | 0.5174 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2536 | 0.5174 | 1 |
Onchocerca volvulus | 0.0465 | 0.0253 | 0.5 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2536 | 0.5174 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0465 | 0.0253 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0465 | 0.0253 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0465 | 0.0253 | 0.5 |
Onchocerca volvulus | 0.0465 | 0.0253 | 0.5 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0465 | 0.0253 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to MAO-B in human brain cortical gray matter at 4 MBq after 90 mins by autoradiography | ChEMBL. | 21923198 | |
Activity (binding) | Binding affinity to MAO-B in human brain white matter at 4 MBq after 90 mins by autoradiography in presence of 10 uM MAO-A inhibitor pirlindole | ChEMBL. | 21923198 | |
Activity (binding) | Binding affinity to MAO-B in human brain white matter at 4 MBq after 90 mins by autoradiography in presence of 10 uM MAO-B inhibitor rasagiline | ChEMBL. | 21923198 | |
Activity (binding) | Binding affinity to MAO-B in human brain white matter at 4 MBq after 90 mins by autoradiography | ChEMBL. | 21923198 | |
Activity (binding) | Binding affinity to MAO-B in human brain white matter at 4 MBq after 90 mins by autoradiography in presence of 10 uM MAO-B inhibitor L-deprenyl | ChEMBL. | 21923198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.