Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1079 | 0.1887 | 0.1605 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0331 | 0.0539 | 0.0954 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0331 | 0.0539 | 0.041 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0107 | 0.0135 | 0.0238 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0681 | 0.1168 | 0.1048 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1079 | 0.1887 | 0.1887 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0681 | 0.1168 | 0.1168 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0331 | 0.0539 | 0.0954 |
Echinococcus granulosus | choline O acetyltransferase | 0.0681 | 0.1168 | 0.2069 |
Loa Loa (eye worm) | hypothetical protein | 0.0681 | 0.1168 | 0.1168 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1079 | 0.1887 | 0.1776 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0336 | 0.0547 | 0.0418 |
Schistosoma mansoni | tyrosine kinase | 0.0175 | 0.0257 | 0.1186 |
Onchocerca volvulus | 0.0681 | 0.1168 | 1 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0179 | 0.0264 | 0.0467 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0681 | 0.1168 | 0.2069 |
Echinococcus multilocularis | 0.0102 | 0.0125 | 0.0222 | |
Schistosoma mansoni | tyrosine kinase | 0.0331 | 0.0539 | 0.3909 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0331 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.558 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0179 | 0.0264 | 0.0467 |
Schistosoma mansoni | choline o-acyltransferase | 0.0681 | 0.1168 | 1 |
Onchocerca volvulus | 0.0681 | 0.1168 | 1 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0681 | 0.1168 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0107 | 0.0135 | 0.0238 |
Schistosoma mansoni | tyrosine kinase | 0.0175 | 0.0257 | 0.1186 |
Schistosoma mansoni | tyrosine kinase | 0.0179 | 0.0264 | 0.1251 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3165 | 0.5647 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0314 | 0.0507 | 0.0239 |
Brugia malayi | Choline O-acetyltransferase | 0.0681 | 0.1168 | 0.1048 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3165 | 0.5647 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0107 | 0.0135 | 0.0238 |
Schistosoma mansoni | tyrosine kinase | 0.0179 | 0.0264 | 0.1251 |
Echinococcus granulosus | insulin receptor | 0.0107 | 0.0135 | 0.0238 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0179 | 0.0264 | 0.0467 |
Onchocerca volvulus | 0.0681 | 0.1168 | 1 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1079 | 0.1887 | 0.3341 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0107 | 0.0135 | 0.0135 |
Brugia malayi | Choline O-acetyltransferase | 0.0681 | 0.1168 | 0.1048 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1079 | 0.1887 | 0.1605 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1079 | 0.1887 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0681 | 0.1168 | 0.1168 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0336 | 0.0547 | 0.0547 |
Schistosoma mansoni | tyrosine kinase | 0.0175 | 0.0257 | 0.1186 |
Onchocerca volvulus | 0.0681 | 0.1168 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3165 | 0.5647 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3165 | 0.5647 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1079 | 0.1887 | 0.3341 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3165 | 0.5647 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.