Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | epidermal growth factor receptor | 0.0168 | 0.0127 | 0.0247 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.2738 | 0.2286 | 0.2741 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0168 | 0.0127 | 0.0096 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0054 | 0.0032 | 0.0062 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0168 | 0.0127 | 0.0247 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.145 | 0.1204 | 0.1204 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.145 | 0.1204 | 0.1176 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.2738 | 0.2286 | 0.2286 |
Echinococcus granulosus | choline O acetyltransferase | 0.145 | 0.1204 | 0.2339 |
Loa Loa (eye worm) | hypothetical protein | 0.145 | 0.1204 | 0.1204 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.017 | 0.0129 | 0.0098 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.2738 | 0.2286 | 0.2261 |
Schistosoma mansoni | tyrosine kinase | 0.0089 | 0.0061 | 0.0246 |
Onchocerca volvulus | 0.145 | 0.1204 | 1 | |
Echinococcus multilocularis | choline O acetyltransferase | 0.145 | 0.1204 | 0.2339 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.009 | 0.0062 | 0.0121 |
Schistosoma mansoni | tyrosine kinase | 0.0168 | 0.0127 | 0.0812 |
Echinococcus multilocularis | 0.0052 | 0.003 | 0.0057 | |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0168 | 0.0127 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 1.1922 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.009 | 0.0062 | 0.0121 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.6146 | 0.5149 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0062 | 0.026 |
Brugia malayi | Choline O-acetyltransferase | 0.145 | 0.1204 | 0.1176 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0159 | 0.012 | 0.0035 |
Echinococcus multilocularis | insulin receptor | 0.0054 | 0.0032 | 0.0062 |
Schistosoma mansoni | choline o-acyltransferase | 0.145 | 0.1204 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.145 | 0.1204 | 1 |
Onchocerca volvulus | 0.145 | 0.1204 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0089 | 0.0061 | 0.0246 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0054 | 0.0032 | 0.0062 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0062 | 0.026 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.6146 | 0.5149 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0054 | 0.0032 | 0.0032 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.2738 | 0.2286 | 0.4439 |
Brugia malayi | Choline O-acetyltransferase | 0.145 | 0.1204 | 0.1176 |
Echinococcus granulosus | insulin receptor | 0.0054 | 0.0032 | 0.0062 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.009 | 0.0062 | 0.0121 |
Onchocerca volvulus | 0.145 | 0.1204 | 1 | |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.2738 | 0.2286 | 0.2741 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.2738 | 0.2286 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.145 | 0.1204 | 0.1204 |
Onchocerca volvulus | 0.145 | 0.1204 | 1 | |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.017 | 0.0129 | 0.0129 |
Schistosoma mansoni | tyrosine kinase | 0.0089 | 0.0061 | 0.0246 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.2738 | 0.2286 | 0.4439 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.6146 | 0.5149 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.6146 | 0.5149 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.6146 | 0.5149 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 0.1 uM after 6 days by MTT colorimetric microassay | ChEMBL. | 22036229 | |
GI (functional) | = 60 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 10 uM after 6 days by MTT colorimetric microassay | ChEMBL. | 22036229 |
IC50 (functional) | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by MTT colorimetric microassay | ChEMBL. | 22036229 | |
MBC (functional) | = 62.5 uM | Antimicrobial activity against Escherichia coli CIP 53126 after 18 to 24 hrs by broth microdilution method | ChEMBL. | 22036229 |
MIC (functional) | > 10 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by MTT colorimetric microassay | ChEMBL. | 22036229 |
MIC (functional) | = 62.5 uM | Antimicrobial activity against Escherichia coli CIP 53126 after 18 to 24 hrs by broth microdilution method | ChEMBL. | 22036229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.