Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0975 | 0.1146 | 0.5 | |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0145 | 0.0061 | 0.0107 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.163 | 0.2002 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0975 | 0.1146 | 0.1124 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.163 | 0.2002 | 0.1898 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.4423 | 0.5653 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.163 | 0.2002 | 0.3541 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.4423 | 0.5653 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.4423 | 0.5653 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0975 | 0.1146 | 0.1137 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.4423 | 0.5653 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0975 | 0.1146 | 0.2028 |
Schistosoma mansoni | choline o-acyltransferase | 0.0975 | 0.1146 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0975 | 0.1146 | 0.1137 |
Loa Loa (eye worm) | hypothetical protein | 0.7748 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0134 | 0.0046 | 0.0402 |
Onchocerca volvulus | 0.0975 | 0.1146 | 0.5 | |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.163 | 0.2002 | 0.1993 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0975 | 0.1146 | 0.2028 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.4423 | 0.5653 | 1 |
Onchocerca volvulus | 0.0975 | 0.1146 | 0.5 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.163 | 0.2002 | 0.1982 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0061 | 0.0036 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0145 | 0.0061 | 0.0107 |
Onchocerca volvulus | 0.0975 | 0.1146 | 0.5 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.163 | 0.2002 | 0.1898 |
Brugia malayi | Choline O-acetyltransferase | 0.0975 | 0.1146 | 0.1137 |
Loa Loa (eye worm) | hypothetical protein | 0.0975 | 0.1146 | 0.1124 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0975 | 0.1146 | 0.1124 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0118 | 0.0025 | 0.0014 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.163 | 0.2002 | 0.3541 |
Schistosoma mansoni | choline o-acyltransferase | 0.0975 | 0.1146 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.