Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0319 | 0.1009 | 0.1009 |
Onchocerca volvulus | 0.0319 | 0.1009 | 0.5 | |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0484 | 0.1653 | 0.1385 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0484 | 0.1653 | 0.1385 |
Onchocerca volvulus | 0.0319 | 0.1009 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0484 | 0.1653 | 0.1385 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1512 | 0.5663 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1512 | 0.5663 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0484 | 0.1653 | 0.1653 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1512 | 0.5663 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0319 | 0.1009 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.1009 | 0.1009 |
Brugia malayi | Choline O-acetyltransferase | 0.0319 | 0.1009 | 0.1009 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1512 | 0.5663 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0319 | 0.1009 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2624 | 1 | 1 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0484 | 0.1653 | 0.1385 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0319 | 0.1009 | 0.1009 |
Schistosoma mansoni | choline o-acyltransferase | 0.0319 | 0.1009 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0484 | 0.1653 | 0.1653 |
Brugia malayi | Choline O-acetyltransferase | 0.0319 | 0.1009 | 0.1009 |
Onchocerca volvulus | 0.0319 | 0.1009 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0484 | 0.1653 | 1 |
Onchocerca volvulus | 0.0319 | 0.1009 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1512 | 0.5663 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4467 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.