Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0455 | 0.0717 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.2464 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 0 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.142 | 0.5176 | 1 |
Onchocerca volvulus | 0.0299 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0455 | 0.0717 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0299 | 0 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0455 | 0.0717 | 0.0717 |
Onchocerca volvulus | 0.0299 | 0 | 0.5 | |
Onchocerca volvulus | 0.0299 | 0 | 0.5 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0455 | 0.0717 | 0.1386 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0455 | 0.0717 | 0.1386 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.142 | 0.5176 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0299 | 0 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0455 | 0.0717 | 0.1386 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.142 | 0.5176 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.142 | 0.5176 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.142 | 0.5176 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0455 | 0.0717 | 0.0717 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12.3 nM | Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 production by ELISA technique | ChEMBL. | 21995460 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.