Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0803 | 0.108 |
Echinococcus granulosus | glutathione s transferase mu | 0.033 | 0.2033 | 0.2033 |
Echinococcus multilocularis | prostaglandin H2 D isomerase | 0.0277 | 0.1498 | 0.7369 |
Echinococcus multilocularis | glutathione S-transferase | 0.033 | 0.2033 | 1 |
Schistosoma mansoni | GST class-mu | 0.033 | 0.2033 | 0.2761 |
Echinococcus granulosus | glutathione S transferase | 0.033 | 0.2033 | 0.2033 |
Loa Loa (eye worm) | hypothetical protein | 0.0867 | 0.7433 | 1 |
Trichomonas vaginalis | glutaminyl-tRNA synthetase, putative | 0.0208 | 0.0803 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.086 | 0.7362 | 1 |
Onchocerca volvulus | 0.0208 | 0.0803 | 0.5 | |
Brugia malayi | glutathione transferase | 0.0867 | 0.7433 | 1 |
Echinococcus multilocularis | glutathione S transferase | 0.033 | 0.2033 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0313 | 0.186 | 0.2526 |
Echinococcus multilocularis | glutathione S transferase | 0.0277 | 0.1498 | 0.7369 |
Echinococcus multilocularis | glutathione s transferase mu | 0.033 | 0.2033 | 1 |
Schistosoma mansoni | Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) | 0.0277 | 0.1498 | 0.2035 |
Schistosoma mansoni | glutathione-S-transferase | 0.033 | 0.2033 | 0.2761 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0128 | 0 | 0.5 |
Echinococcus multilocularis | glutathione S transferase | 0.0261 | 0.1338 | 0.6582 |
Echinococcus multilocularis | glutathione S transferase | 0.0261 | 0.1338 | 0.6582 |
Echinococcus granulosus | glutathione S transferase | 0.0208 | 0.0803 | 0.0803 |
Plasmodium vivax | glutathione S-transferase, putative | 0.0277 | 0.1498 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0313 | 0.186 | 0.2526 |
Plasmodium falciparum | glutathione S-transferase | 0.033 | 0.2033 | 1 |
Echinococcus granulosus | prostaglandin H2 D isomerase | 0.0277 | 0.1498 | 0.1498 |
Echinococcus multilocularis | glutathione S transferase | 0.033 | 0.2033 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0128 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.